Catalog No.
YHJ36801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln358
Predicted molecular weight
41.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969S8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HDAC10, Polyamine deacetylase HDAC10, HD10, Histone deacetylase 10
TR-FRET assay for profiling HDAC10 inhibitors and PROTACs., PMID:40382152
Cell-based determination of HDAC10-mediated polyamine deacetylase activity., PMID:40382147
Expression, purification, and crystallization of "humanized" Danio rerio histone deacetylase 10 "HDAC10", the eukaryotic polyamine deacetylase., PMID:40382137
Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma., PMID:40320542
The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells., PMID:40301616
High levels of histone acetylation modifications promote the formation of PGCs., PMID:39798283
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases., PMID:39707387
A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line., PMID:39704853
An 8-Week Very Low-Calorie Ketogenic Diet (VLCKD) Alters the Landscape of Obese-Derived Small Extracellular Vesicles (sEVs), Redefining Hepatic Cell Phenotypes., PMID:39683581
Preliminary study of the role of histone deacetylase (HDAC) in steroid-induced avascular necrosis of the femoral head induced by BMSC adipogenic differentiation., PMID:39396027
Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas., PMID:39353908
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis., PMID:39237939
Histone deacetylase expression following cisplatin-induced acute kidney injury in male and female mice., PMID:39116350
Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165., PMID:38956592
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells., PMID:38881946
Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia-Reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain., PMID:38685198
HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression., PMID:38650694
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases., PMID:38530703
Chidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway., PMID:38381215
HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance., PMID:38106051
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment., PMID:37848136
Comprehensive Characterization of HATs and HDACs in Human Cancers Reveals Their Role in Immune Checkpoint Blockade., PMID:37824391
Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels., PMID:37657752
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer., PMID:37633202
The application of PROTAC in HDAC., PMID:37607440
The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation., PMID:37441601
RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming., PMID:37408139
Exploring structural requirements of HDAC10 inhibitors through comparative machine learning approaches., PMID:37216830
Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy., PMID:37144599
Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells., PMID:36902164
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses., PMID:36538592
MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke-Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade., PMID:36252137
Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy., PMID:36251458
Comprehensive analyses reveal the role of histone deacetylase genes in prognosis and immune response in low-grade glioma., PMID:36227941
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout., PMID:36200994
miR-3,178 contributes to the therapeutic action of baicalein against hepatocellular carcinoma cells via modulating HDAC10., PMID:36070933
Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth., PMID:35988653
Acetylation dependent translocation of EWSR1 regulates CHK2 alternative splicing in response to DNA damage., PMID:35732801
Prognostic Analysis of Differentially Expressed DNA Damage Repair Genes in Bladder Cancer., PMID:35685866
Deacetylation of YAP1 Promotes the Resistance to Chemo- and Targeted Therapy in FLT3-ITD+ AML Cells., PMID:35656547
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement., PMID:35608330
Genetic and Molecular Characterization Revealed the Prognosis Efficiency of Histone Acetylation in Pan-Digestive Cancers., PMID:35422864
Differential Expression of Zinc-Dependent HDAC Subtypes and their Involvement in Unique Pathways Associated with Carcinogenesis., PMID:35345359
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells., PMID:35306288
Short communication: TNF-α and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10., PMID:35143520
LncRNA SOX1-OT V1 acts as a decoy of HDAC10 to promote SOX1-dependent hESC neuronal differentiation., PMID:34927789
Link between obsessive-compulsive disorder and polymorphisms in HDAC genes., PMID:34730715
DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC., PMID:34382524
Identification of unique subtype-specific interaction features in Class II zinc-dependent HDAC subtype binding pockets: A computational study., PMID:34323221
Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma., PMID:34308568
For research use only. Not for human or drug use.
