Catalog No.
YHJ36201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser23-Gln76
Predicted molecular weight
33.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969E1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LEAP2, Liver-expressed antimicrobial peptide 2, LEAP-2
Brain-acting hepatokines: its impact on energy balance and metabolism., PMID:40443802
The Connection Between the Appetite-Regulatory Peptides Ghrelin and GLP-1 and Alcohol Use Disorder., PMID:40442388
ASS1 is a hub gene and possible therapeutic target for regulating metabolic dysfunction-associated steatotic liver disease modulated by a carbohydrate-restricted diet., PMID:40244373
Molecular characterization of an antimicrobial peptide LEAP-2 in Onychostoma macrolepis: Expression pattern, antimicrobial ability and immunomodulation function., PMID:40121727
Associations between major depressive disorders and Parkinson's Disease and impact of their comorbidity sequence., PMID:40088986
Identification and characterisation of LEAP2 from Chinese spiny frogs (Quasipaa spinosa) with antimicrobial and macrophage activation properties., PMID:40082911
Regulation of LEAP2 by insulin and glucagon in mice and humans., PMID:40056903
Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2)., PMID:39860298
Oral administration of LEAP2 enhances immunity against Edwardsiella tarda through regulation of gut bacterial community and metabolite in mudskipper., PMID:39824300
Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism., PMID:39823403
LEAP2 in Physiology-A Narrative Review., PMID:39796232
Ghrelin-LEAP2 interactions along the stomach-liver axis., PMID:39756956
FADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel., PMID:39755288
[Correlation between serum ghrelin and liver-expressed antimicrobial peptide-2 with idiopathic short stature in children]., PMID:39725387
Simultaneous treatment with palm-LEAP2(1-14) and feeding high-fat diet attenuates liver lipid metabolism but not obesity: Sign of selective resistance to palm-LEAP2(1-14)., PMID:39689753
MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest., PMID:39586385
Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight., PMID:39433849
Increased GHS-R1a expression in the hippocampus impairs memory encoding and contributes to AD-associated memory deficits., PMID:39415032
Antibacterial activity of recombinant liver-expressed antimicrobial peptide-2 derived from olive flounder, Paralichthys olivaceus., PMID:39389171
Evaluating performance, intestinal lesions, and immunity related genes in heritage and modern broiler breeds during a necrotic enteritis challenge., PMID:39366291
LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents., PMID:39358354
Deficiency of leap2 promotes somatic growth in zebrafish: Involvement of the growth hormone system., PMID:39347412
The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in Male Mice and Patients., PMID:39331742
The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner., PMID:39292603
The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life., PMID:39277116
LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans., PMID:39140219
In vitro pharmacological characterization of growth hormone secretagogue receptor ligands using the dynamic mass redistribution and calcium mobilization assays., PMID:39128804
GHSR signalling in perinatal phases is involved in liver metabolism at puberty., PMID:39045853
Exposure to Trimethyltin Chloride Induces Pyroptosis and Immune Dysfunction in Grass Carp CIK Cells by Activating the NF-κB Pathway Through Oxidative Stress., PMID:39004893
Impacts of Central Administration of the Novel Peptide, LEAP-2, in Different Food Intake Models in Conscious Rats., PMID:38931301
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study., PMID:38888057
Structure-activity relationships of the intramolecular disulphide bonds in LEAP2, an antimicrobial peptide from Acrossocheilus fasciatus., PMID:38835040
CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism., PMID:38830459
Niclosamide subacute exposure alters the immune response and microbiota of the gill and gut in black carp larvae, Mylopharyngodon piceus., PMID:38805826
Preliminary study on the diagnostic value of LEAP-2 and CK18 in biopsy-proven MAFLD., PMID:38778244
A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice., PMID:38697291
Intestinal expression profiles and hepatic expression of LEAP2, ghrelin and their common receptor, GHSR, in humans., PMID:38657907
Decoding the influence of central LEAP2 on food intake and its effect on accumbal dopamine release., PMID:38641041
Quail GHRL and LEAP2 gene cloning, polymorphism detection, phylogenetic analysis, tissue expression profiling and its association analysis with feed intake., PMID:38636815
Impact of Ghrelin on Islet Size in Nonpregnant and Pregnant Female Mice., PMID:38626085
Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer., PMID:38577455
Association between endocrine and neuropsychological endophenotypes and gambling disorder severity., PMID:38447412
Molecular characterization, antibacterial and immunoregulatory activities of liver-expressed antimicrobial peptide 2 in black rockfish, Sebastes schlegelii., PMID:38423489
The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging., PMID:38337094
Identification of antibacterial activity of liver-expressed antimicrobial peptide 2 (LEAP2) from primitive vertebrate lamprey., PMID:38311092
Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner., PMID:38157050
Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications., PMID:38141066
High-Fat Diet Induces Resistance to Ghrelin and LEAP2 Peptide Analogs in Mice., PMID:38015760
New insights into the antimicrobial mechanism of LEAP2 mutant zebrafish under Aeromonas hydrophila infection using transcriptome analysis., PMID:37977545
For research use only. Not for human or drug use.
