Catalog No.
EHJ35101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Val202
Predicted molecular weight
22.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92956
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HVEA, HVEM, Herpes virus entry mediator A, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2, HveA, TNFRSF14, CD270, TR2, Herpesvirus entry mediator A
Increased Herpesvirus Entry Mediator Expression on Circulating Monocytes and Subsets Predicts Poor Outcomes in Pancreatic Ductal Adenocarcinoma Patients., PMID:40243455
Tumor Cell-Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer., PMID:40105652
The Function of B and T Lymphocyte Attenuator and Its Role in Transplantation., PMID:40040475
Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy., PMID:39904774
Soluble Herpes Virus Entry Mediator and Type II/III Interferons Are Upregulated in Primary Biliary Cholangitis., PMID:39859319
HVEM as a tumor-intrinsic regulator in non-small cell lung cancer: Suppression of metastasis via glycolysis inhibition and modulation of macrophage polarization., PMID:39832683
[Expression of BTLA/HVEM axis in hematological and prospects for immune target therapy]., PMID:39799427
CD34+ and CD34- MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells., PMID:39531203
Distinct characteristics of BTLA/HVEM axis expression on Tregs and its impact on the expansion and attributes of Tregs in patients with active pulmonary tuberculosis., PMID:39386167
Effect of HVEM/CD160 Variations on the Clear Cell Renal Carcinoma Risk and Overall Survival., PMID:38999968
Modulation of blood T cell polyfunctionality and HVEM/BTLA expression are critical determinants of clinical outcome in anti-PD1-treated metastatic melanoma patients., PMID:38939518
The effect of gD-derived peptides on T cell immune response mediated by BTLA-HVEM protein complex in melanoma patients., PMID:38835768
The BTLA-HVEM axis restricts CAR T cell efficacy in cancer., PMID:38831106
Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia., PMID:38785930
Targeting BTLA with the peptide inhibitor HVEM(14-39) - A new way to restore the activity of T cells in melanoma., PMID:38733770
B- and T-Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis., PMID:38676311
The role of the BTLA-HVEM complex in the pathogenesis of breast cancer., PMID:38483699
Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis., PMID:37722959
T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines., PMID:37500142
Isolation and Characterization of Novel Canine Osteosarcoma Cell Lines from Chemotherapy-Naïve Patients., PMID:37048099
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression., PMID:37033927
Prospective, longitudinal analysis of the gut microbiome in patients with locally advanced rectal cancer predicts response to neoadjuvant concurrent chemoradiotherapy., PMID:36967379
Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2., PMID:36552785
A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion., PMID:35987137
The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases., PMID:35537322
Clinical Significance of BTLA and HVEM Expression on Circulating CD4+ T and CD8+ T Cells in Chronic Hepatitis B Virus Infection., PMID:35196150
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects., PMID:34879275
A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer., PMID:34858395
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160., PMID:34709351
Retrospective analyses of other iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with rheumatic diseases., PMID:34558064
Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype., PMID:34478526
Virtual Evolution of HVEM Segment for Checkpoint Inhibitor Discovery., PMID:34205742
The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps., PMID:34083106
Thyroid MALT lymphoma: self-harm to gain potential T-cell help., PMID:34021249
Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes., PMID:33945543
Tumor microenvironment immune subtypes for classification of novel clear cell renal cell carcinoma profiles with prognostic and therapeutic implications., PMID:33725966
Investigation of IL-4, IL-10, and HVEM polymorphisms with esophageal squamous cell carcinoma: a case-control study involving 1929 participants., PMID:32744314
Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype., PMID:32712105
Primary superficial Ewing sarcoma: A unique entity? A case report including novel findings of ELF3 and TNFRSF14 copy number loss., PMID:32483824
The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA., PMID:32454905
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies., PMID:32398677
Circulating tumor DNA predicts response in Chinese patients with relapsed or refractory classical hodgkin lymphoma treated with sintilimab., PMID:32304999
Existence of Circulating Mitochondria in Human and Animal Peripheral Blood., PMID:32204530
Expression of herpesvirus entry mediator gene as a potential biomarker for disease severity in patients with persistent asthma., PMID:32045312
[Expression and Significance of BTLA and Its Ligand HVEM in Patients with Chronic Myelomonocytic Leukemia]., PMID:32027253
Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding., PMID:31963646
Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression., PMID:31522034
Indolent In Situ B-Cell Neoplasms With MYC Rearrangements Show Somatic Mutations in MYC and TNFRSF14 by Next-generation Sequencing., PMID:31368914
Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis., PMID:31313042
Structural Basis of CD160:HVEM Recognition., PMID:31230945
For research use only. Not for human or drug use.
