Catalog No.
YHJ35001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val1151-Gly1241
Predicted molecular weight
12.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92954
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MSF, Superficial zone proteoglycan, Megakaryocyte-stimulating factor, PRG4, SZP, Proteoglycan 4, Lubricin
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome Caused by Truncating Mutations in the Prg4 Gene: Case Series and Literature Review., PMID:40475173
Chondroitin sulfate/hyaluronic acid/carboxymethylcellulose macroporous cryogels for controlled delivery of TGF-β1 and IGF-1 to induce chondrogenic differentiation of adipose-derived stem cells in cartilage tissue engineering., PMID:40449777
Lubricin (PRG4) antifouling coating enables the development of an immunosensor for the detection of nerve growth factor in cell culture media., PMID:40300472
Knockdown of circRNA_0030042 Attenuates Heart Failure via miR-568/PRG4 Pathway., PMID:40293855
IL-1β inhibition in stabilizing atherosclerotic plaques: The critical role of fibroblast-like cells., PMID:40180256
Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies., PMID:40149669
Glycoproteoforms of Osteoarthritis-associated Lubricin in Plasma and Synovial Fluid., PMID:39922311
Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model., PMID:39791731
Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis., PMID:39696446
Patient-responsive protein biomarkers for cartilage degeneration and repair identified in the infrapatellar fat pad., PMID:39635821
Bioengineered lubricin alters the lubrication modes of cartilage in a dose-dependent manner., PMID:39521731
Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls., PMID:39405606
Proteoglycan 4 (Lubricin) and Regulation of Xanthine Oxidase in Synovial Macrophage as A Mechanism of Controlling Synovitis., PMID:39372933
TNFα-Induced Inflammation Model-Evaluation of Concentration and Passage-Dependent Effects on Bovine Chondrocytes., PMID:39273085
SHP2 ablation mitigates osteoarthritic cartilage degeneration by promoting chondrocyte anabolism through SOX9., PMID:39225365
Chondroid Synoviocytic Neoplasm: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of a Distinctive Tumor of Synoviocytes., PMID:39181450
Synovial mesenchymal stem cells secrete more lubricin than adipose mesenchymal stem cells after injection into rat osteoarthritis knees., PMID:38981403
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome., PMID:38955384
UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis., PMID:38955308
Shotgun Proteomics Links Proteoglycan-4+ Extracellular Vesicles to Cognitive Protection in Amyotrophic Lateral Sclerosis., PMID:38927130
PRG4 mitigates hemorrhagic shock-induced cardiac injury by inhibiting mitochondrial dysregulation, oxidative stress and NLRP3-mediated pyroptosis., PMID:38897120
Prg4-Expressing Chondroprogenitor Cells in the Superficial Zone of Articular Cartilage., PMID:38891793
Load-induced blood marker kinetics in patients with medial knee compartment osteoarthritis are associated with accumulated load and patient reported outcome measures., PMID:38882712
Thirteen Indians with camptodactyly-arthropathy-coxa vara-pericarditis syndrome., PMID:38856641
Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis., PMID:38825675
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis., PMID:38783531
PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression., PMID:38781792
Genome Sequencing in an Individual Presenting with 22q11.2 Deletion Syndrome and Juvenile Idiopathic Arthritis., PMID:38674447
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice., PMID:38606903
Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model., PMID:38604493
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome and an unusual association with mitral stenosis., PMID:38523390
Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model., PMID:38498368
Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis., PMID:38432607
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes., PMID:38432573
Calcium ions have a detrimental impact on the boundary lubrication property of hyaluronic acid and lubricin (PRG-4) both alone and in combination., PMID:38184943
Plasma proteome profiling reveals the therapeutic effects of the PPAR pan-agonist chiglitazar on insulin sensitivity, lipid metabolism, and inflammation in type 2 diabetes., PMID:38182717
Scale-Dependent Rheology of Synovial Fluid Lubricating Macromolecules., PMID:38161247
Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins., PMID:38129841
PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis., PMID:38111181
Downregulation of extracellular matrix protein 1 effectively ameliorates osteoarthritis progression in vivo., PMID:38039715
CD39+CD55- Fb Subset Exhibits Myofibroblast-Like Phenotype and Is Associated with Pain in Osteoarthritis of the Knee., PMID:38002046
Lubricin (PRG-4) anti-fouling coating for surface-enhanced Raman spectroscopy biosensing: towards a hierarchical separation system for analysis of biofluids., PMID:37933547
Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4)., PMID:37895896
Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin., PMID:37760099
Deciphering mechanisms of cardiomyocytes and non-cardiomyocyte transformation in myocardial remodeling of permanent atrial fibrillation., PMID:37722560
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo., PMID:37681409
A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843., PMID:37678729
Suppression of antitumor cytokine IL‑24 by PRG4 and PAI‑1 may promote myxoid liposarcoma cell survival., PMID:37614985
Immunomodulatory potential of mesenchymal stromal cell-derived extracellular vesicles in chondrocyte inflammation., PMID:37564645
CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence., PMID:37440279
For research use only. Not for human or drug use.
