Catalog No.
YHJ34401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1300-Glu1534
Predicted molecular weight
28.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92887
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2, Canalicular multispecific organic anion transporter 1, ABCC2, CMOAT, Canalicular multidrug resistance protein, MRP2, CMRP, CMOAT1
Nano-pectic polysaccharide from vinegar-baked Radix Bupleuri enhances methotrexate efficacy against hepatocellular carcinoma via BCRP and MRP2 downregulation., PMID:40484088
[Frontline in Biliary Excretion of Drugs and Their Evaluation Systems]., PMID:40451870
Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance., PMID:40429829
Molecular pharmacokinetic mechanism of JBP485 against aristolochic acid I (AAI) -induced nephrotoxicity., PMID:40371353
Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients., PMID:40369345
Effect of tripterine on the pharmacokinetics of cyclosporine A and its mechanism in rats., PMID:40364906
Acridine-Based Chalcone 1C and ABC Transporters., PMID:40362377
Investigation of the attenuation effect of licorice on the toxicity of rhubarb using a P-gp lipid raft bioaffinity chromatography., PMID:40334758
Acute Response of Hepatocyte MRP2 Internalization as an Indicator of Ischemia-Reperfusion Injury in Liver Transplantation., PMID:40320583
Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population., PMID:40297930
Association of ABC Efflux Transporter Genetic Variants and Adverse Drug Reactions and Survival in Patients with Non-Small Lung Cancer., PMID:40282412
Effects of Benzo[k]fluoranthene at Two Temperatures on Viability, Structure, and Detoxification-Related Genes in Rainbow Trout RTL-W1 Cell Spheroids., PMID:40278618
Two pathways mediate toxicity of Cry1Ac in Mythimna separata: one is ABCC2-dependent and the other involves ABCC3-CAD interaction., PMID:40268035
Cry2 Alleviates Cisplatin-Induced Cytotoxicity in Mouse Renal Cortex Tubular Cell Lines., PMID:40254427
Oxidative stress promotes post-translational down-regulation of MRP2 in Caco-2 cells: Involvement of proteasomal degradation and toxicological implications., PMID:40252905
PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma., PMID:40251307
Functional redundancy in the toxic pathway of Bt protein Cry1Ab, but not Cry1Fa, against the Asian corn borer., PMID:40244677
Impact of hepatic impairment and renal failure on the pharmacokinetics of linezolid and its metabolites: contribution of hepatic metabolism and renal excretion., PMID:40227039
Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review., PMID:40222694
Pharmacogenetics to optimize immunosuppressant therapy in systemic lupus erythematosus: a scoping review., PMID:40208755
Relevance of transportome among the mechanisms of chemoresistance in hepatoblastoma., PMID:40185314
Analysis of drug transporter expression in syncytiotrophoblast derived from human placental stem cells: Expression and function of efflux transporters., PMID:40184769
Model of baseline clinicopathological features predicts non-resolution of drug-induced liver injury at 6 months., PMID:40180706
Switch/sucrose non-fermentable complex interacts with constitutive androstane receptor to regulate drug-metabolizing enzymes and transporters in the liver., PMID:40158296
Inhibition of ABC transporters by sorafenib and lenvatinib: implications for drug-induced cholestasis., PMID:40096842
Eukaryotic Translation Initiation Factor 2 Modulates the Expression of Midgut Receptors to Confer Resistance to Bacillus thuringiensis Cry1Ac Toxin in Helicoverpa armigera., PMID:40094927
Alterations of valsartan pharmacokinetics in a rodent model of metabolic dysfunction-associated steatohepatitis., PMID:40054126
Identification of selective substrates and inhibitors of the major human renal uptake transporters., PMID:40024137
Efflux and uptake of androgen sulfates using transporter-overexpressing HEK293 cells and membrane vesicles., PMID:39993711
Physiologically based pharmacokinetic modeling of midostaurin and metabolites at steady-state to bridge drug interaction scenarios in lieu of clinical trials., PMID:39985984
CYP3A4 and MRP2 are predominant metabolic regulators attribute to the toxicity/efficacy of aconitine derived from Fuzi., PMID:39954827
ABCC2 p.R393W variant contributes to Dubin-Johnson syndrome by targeting MRP2 to proteasome degradation., PMID:39944748
[Preparation and intestinal absorption mechanism of herpetrione and Herpetospermum caudigerum polysaccharides based self-assembled nanoparticles]., PMID:39929621
The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol., PMID:39891427
Absolute membrane protein abundance of P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins in term human placenta tissue and commonly used cell systems: Application in physiologically based pharmacokinetic modeling of placental drug disposition., PMID:39884812
Functional expression of Bacillus thuringiensis Cry proteins on the surface of Bacillus subtilis spores., PMID:39877884
Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition., PMID:39864598
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation., PMID:39808251
Functional Characterization and In Silico Prediction Tools Improve the Pathogenicity Prediction of Novel Bile Acid Transporter Variants., PMID:39806568
The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment., PMID:39806313
The effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin., PMID:39803934
Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2., PMID:39779684
Comprehensive Parent-Metabolite PBPK/PD Modeling Insights Into Methotrexate Personalized Dosing Strategies in Patients With Rheumatoid Arthritis., PMID:39778004
Tramadol-related fatalities: Metabolic ratios & SNPs/INDELs belonging to UGT1A8, UGT2B7, ABCC2, and SLC22A1., PMID:39752799
Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions., PMID:39746499
Evaluation of methotrexate Pharmacogenomic variation to predict acute neurotoxicity in children with acute lymphoblastic leukemia., PMID:39734275
Impaired renal transporter gene expression and uremic toxin excretion as aging hallmarks in cats with naturally occurring chronic kidney disease., PMID:39729035
Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics., PMID:39713147
Genetic and non-genetic factors influencing the therapeutic response of valproic acid in pediatric epileptic patients., PMID:39711059
Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism., PMID:39707386
For research use only. Not for human or drug use.
