Catalog No.
YHJ34101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu17-Lys244
Predicted molecular weight
27.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92876
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRSS9, Serine protease 9, Neurosin, Zyme, KLK6, SP59, Kallikrein-6, PRSS18, Serine protease 18, Protease M
Analysis of Kallikrein 6, Acetyl-α-Tubulin, and Aquaporin 1 and 2 Expression Patterns During Normal Human Nephrogenesis and in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)., PMID:40428321
A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer., PMID:40156045
Kallikrein-Related Peptidase 6 Contributes to Murine Intestinal Tumorigenesis Driven by a Mutant Adenomatous polyposis coli Gene., PMID:39594797
Identification of CSNK1D and KLK6 as two common upregulated genes present in BRCA1 mutated triple-negative breast cancer and ovarian epithelial carcinoma., PMID:38781585
Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey., PMID:38608749
qRT-PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes-An improved method for assessment of tumor stage and prognosis., PMID:37700602
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages., PMID:36552865
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion., PMID:36413626
KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma., PMID:36193495
Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis., PMID:35883559
KLK6 mediates stemness and metabolism of gastric carcinoma cells via the PI3K/AKT/mTOR signaling pathway., PMID:34691251
CEACAM5, KLK6, SLC35D3, POSTN, and MUC2 mRNA Analysis Improves Detection and Allows Characterization of Tumor Cells in Lymph Nodes of Patients Who Have Colon Cancer., PMID:34192710
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer., PMID:34065672
Application of machine learning to large in vitro databases to identify drug-cancer cell interactions: azithromycin and KLK6 mutation status., PMID:33953352
Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation., PMID:33949859
Ectopic expression of KLK6 in MDA-MB-435 melanoma cells reduces tumorigenicity in vivo., PMID:33249398
Comprehensive Identification of the Human Secretome as Potential Indicators in Treatment Outcome of HPV-Positive and -Negative Cervical Cancer Patients., PMID:33171469
Proteinase KLK6 links skin and joint inflammation in PsA., PMID:32231304
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease., PMID:32155135
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein., PMID:31692974
Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes., PMID:31682009
Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6., PMID:31675166
A proinflammatory role of KLK6 protease in Netherton syndrome., PMID:31255470
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome., PMID:31045568
Biochemical pathways mediated by KLK6 protease in breast cancer., PMID:30980596
KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells., PMID:30607299
Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer., PMID:30287916
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity., PMID:30212625
Effect of Kallikrein-related Peptidase KLK1 on Ameliorating Spermatogenesis Regeneration in Busulfan-induced Azoospermic Mice and Promoting Mouse Spermatogonial Stem Cell Proliferation In Vitro., PMID:30171922
Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6., PMID:30015976
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy., PMID:29993134
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering., PMID:29934309
KLK10 exon 3 unmethylated PCR product concentration: a new potential early diagnostic marker in ovarian cancer? - A pilot study., PMID:29690914
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism., PMID:29641412
Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments., PMID:29563071
Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients., PMID:29435805
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease., PMID:29378650
Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing., PMID:29229980
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma., PMID:29224812
Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI., PMID:28726131
Study of kallikrein-related peptidase 6 (KLK6) and its complex with α1-antitrypsin in biological fluids., PMID:28672746
Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6., PMID:28431272
Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer., PMID:28376164
Prostate cancer: In a SNP: KLK6 mutations in aggressive disease., PMID:28374791
Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?, PMID:28254587
Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer., PMID:27863404
Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck., PMID:27844409
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer., PMID:27483364
Validation of a Novel Biomarker Panel for the Detection of Ovarian Cancer., PMID:27448593
Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids., PMID:27283773
For research use only. Not for human or drug use.
