Catalog No.
YHJ33801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe223-Ile459
Predicted molecular weight
28.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92851
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, CASP-10, MCH4, ICE-like apoptotic protease 4, Apoptotic protease Mch-4, CASP10, Caspase-10
Comprehensive Pan-cancer Analysis Revealed CASP10 As a Promising Biomarker For Diverse Tumor Types., PMID:40152300
Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome., PMID:38704374
Case report: Synergistic defects of CASP10 and BTK leading to autoimmune lymphoproliferative syndrome type IIa, complicated by severe hemophagocytic lymphohistiocytosis., PMID:37067653
Gelsolin Inhibits the Proliferation of Colon Cancer Cells by Enhancing the Expression of TNFR2/CASP10 as a Death Receptor Pathway., PMID:36734906
Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis., PMID:34463927
Variants in CASP10, a diagnostic challenge: Single center experience and review of the literature., PMID:34329798
Mutational analysis of apoptotic genes in familial aggregation of hematological malignancies., PMID:34140154
Long noncoding RNA PVT1 facilitates high glucose-induced cardiomyocyte death through the miR-23a-3p/CASP10 axis., PMID:33049089
lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease., PMID:32089625
Thrombotic thrombocytopenic purpura and defective apoptosis due to CASP8/10 mutations: the role of mycophenolate mofetil., PMID:31714957
Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis., PMID:31534141
FAS-mediated apoptosis impairment in patients with ALPS/ALPS-like phenotype carrying variants on CASP10 gene., PMID:31309545
Inverse Association Between Antiviral Immunity and Lupus Disease Activity., PMID:30394862
MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression., PMID:29322788
Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment., PMID:29099485
Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population., PMID:28643196
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway., PMID:27827850
Atypical presentation of autoimmune lymphoproliferative syndrome due to CASP10 mutation., PMID:27378136
Proteome-wide covalent ligand discovery in native biological systems., PMID:27309814
PDP-CON: prediction of domain/linker residues in protein sequences using a consensus approach., PMID:26969678
Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation., PMID:26323380
Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells., PMID:26164758
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease., PMID:26113417
Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy., PMID:25805750
MQAPsingle: A quasi single-model approach for estimation of the quality of individual protein structure models., PMID:25737479
Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic Lupus erythematosus., PMID:25370148
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain., PMID:25330190
Structural mechanisms in NLR inflammasome signaling., PMID:25201319
Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways., PMID:24759787
Differential responses to rhinovirus- and influenza-associated pulmonary exacerbations in patients with cystic fibrosis., PMID:24641803
Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines., PMID:24037645
Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population., PMID:23303631
Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis., PMID:23212337
Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis., PMID:22926077
Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer., PMID:22843554
The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling., PMID:22782902
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis., PMID:22528489
The role of BCL11B in regulating the proliferation of human naive T cells., PMID:22426257
N-acetylcysteine modulates the cytotoxic effects of Paclitaxel., PMID:21778718
Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer., PMID:21559821
Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers., PMID:20978178
Is the deficiency of the long isoform of cellular FLICE-inhibitory protein involved in myocardial remodeling?, PMID:20975034
Activation and specificity of human caspase-10., PMID:20795673
Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells., PMID:20439934
Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas., PMID:20025484
Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas., PMID:19900088
Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions., PMID:19561642
Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium., PMID:19423537
Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae., PMID:19166881
Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation., PMID:18948840
For research use only. Not for human or drug use.
