Catalog No.
YHJ33501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp115-Met454
Predicted molecular weight
39.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92824
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PC5, PC6, Proprotein convertase 6, Proprotein convertase subtilisin/kexin type 5, PCSK5, hPC6, Proprotein convertase 5, Subtilisin/kexin-like protease PC5
Genetic Determinants of Colonic Diverticulosis-A Systematic Review., PMID:40428403
Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation., PMID:38972101
PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3., PMID:38553549
Dysregulation of the Skin-Liver Axis in Prurigo Nodularis: An Integrated Genomic, Transcriptomic, and Population-Based Analysis., PMID:38397136
Identification and verification of feature biomarkers associated with immune cells in recurrent pregnancy loss., PMID:38305600
Transcript-aware analysis of rare predicted loss-of-function variants in the UK Biobank elucidate new isoform-trait associations., PMID:38160284
Gene expression profiles to analyze the anticancer and carcinogenic effects of arsenic in bladder cancer., PMID:37969188
Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs., PMID:37672187
Apoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis., PMID:37474514
Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2., PMID:37259108
Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice., PMID:36970723
Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration., PMID:36604669
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease., PMID:36188622
Genetic Alterations in Papillary Thyroid Carcinoma With Hashimoto's Thyroiditis： ANK3, an Indolent Maintainer of Papillary Thyroid Carcinoma., PMID:35646694
Weighted Single-Step Genome-Wide Association Study Uncovers Known and Novel Candidate Genomic Regions for Milk Production Traits and Somatic Cell Score in Valle del Belice Dairy Sheep., PMID:35565582
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes., PMID:35484513
Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease., PMID:35045102
Identification of key tumor stroma-associated transcriptional signatures correlated with survival prognosis and tumor progression in breast cancer., PMID:35020130
Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss., PMID:34710160
RP11-362K2.2:RP11-767I20.1 Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis., PMID:34300314
Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood., PMID:33858964
SNP-adjacent super enhancer network mediates enhanced osteogenic differentiation of MSCs in ankylosing spondylitis., PMID:33355648
MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5., PMID:33313955
Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific., PMID:32031713
Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment., PMID:31695792
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies., PMID:31681577
Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing., PMID:31101650
Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis., PMID:30882467
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions., PMID:30698716
Jagged1 promotes mineralization in human bone-derived cells., PMID:30682716
Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6., PMID:30104250
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer., PMID:29161592
Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone., PMID:29126984
Pcsk5 is required in the early cranio-cardiac mesoderm for heart development., PMID:28446132
Enhanced Proteolytic Processing of Recombinant Human Coagulation Factor VIII B-Domain Variants by Recombinant Furins., PMID:27126696
PCSK5 mutation in a patient with the VACTERL association., PMID:26055999
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure., PMID:25813623
C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function., PMID:25683871
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study., PMID:25604533
Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol., PMID:25351954
Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing., PMID:24454770
Mutation screening and array comparative genomic hybridization using a 180K oligonucleotide array in VACTERL association., PMID:24416387
Relative expression of proprotein convertases in rat ovaries during pregnancy., PMID:24330629
Proprotein convertases in high-density lipoprotein metabolism., PMID:24252756
Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis., PMID:24040146
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios., PMID:23409034
Results of genome-wide analyses on neurodevelopmental phenotypes at four-year follow-up following cardiac surgery in infancy., PMID:23049896
Identification of proprotein convertase substrates using genome-wide expression correlation analysis., PMID:22185580
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL., PMID:21889147
Use of zebrafish and knockdown technology to define proprotein convertase activity., PMID:21805249
For research use only. Not for human or drug use.
