Catalog No.
YHJ32901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly204-Leu364
Predicted molecular weight
19.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92743
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
High-temperature requirement A serine peptidase 1, Serine protease 11, HTRA1, PRSS11, HTRA, Serine protease HTRA1, L56
Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface., PMID:40463243
Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning., PMID:40406620
Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma., PMID:40374042
Extracellular matrix induces trophoblast HtrA4 expression: Implications for the pathogenesis of placenta accreta spectrum., PMID:40334386
N-acetyl-l-leucine lowers pS129-synuclein and improves synaptic function in models of Parkinson's disease., PMID:40297686
In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas., PMID:40272443
Simultaneous GA and CNV/MNV: incidence, characteristics, and treatments., PMID:40229571
Genotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population., PMID:40221144
Exome sequencing of a Portuguese cohort of early-onset Alzheimer's disease implicates the X-linked lysosomal gene GLA., PMID:40185916
Membranous Nephropathy Target Antigens Display Podocyte-Specific and Non-Specific Expression in Healthy Kidneys., PMID:40149392
Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration., PMID:40089174
Genetic Distinctions Between Reticular Pseudodrusen and Drusen: A Genome-Wide Association Study., PMID:40064387
Elevated levels of IRF1 and CASP1 as pyroptosis-related biomarkers for intestinal epithelial cells in Crohn's disease., PMID:40018047
BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma., PMID:40016843
HTRA1 and complement activation in neovascular age-related macular degeneration., PMID:39937341
Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression., PMID:39934701
Ablation of Htra1 leads to sub-RPE deposits and photoreceptor abnormalities., PMID:39927462
Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway., PMID:39922934
Current molecular understanding of central nervous system schwannomas., PMID:39910685
Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review., PMID:39858606
Erratum in: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus., PMID:39813058
The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study., PMID:39802786
L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial., PMID:39764542
Author Response: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus., PMID:39666349
Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus., PMID:39666348
Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1., PMID:39662603
Synergistic Multi-Pronged Interactions Mediate the Effective Inhibition of Alpha-Synuclein Aggregation by the Chaperone HtrA1., PMID:39651184
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries., PMID:39623103
Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design., PMID:39620099
Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway., PMID:39613464
Adult Onset Foveomacular Vitelliform Dystrophy Shows Genetic Overlap With Age-Related Macular Degeneration., PMID:39585675
Microglial activation without peripheral immune cell infiltration characterises mouse and human cerebral small vessel disease., PMID:39543785
Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression., PMID:39500383
Association of polymorphisms in the HTRA1 gene with myopia., PMID:39406463
Protein biomarker signatures of preeclampsia - a longitudinal 5000-multiplex proteomics study., PMID:39390022
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments., PMID:39386146
Significance of pyroptosis-related genes in the diagnosis and classification of diabetic kidney disease., PMID:39378104
High resolution analysis of proteolytic substrate processing., PMID:39313096
Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown., PMID:39293776
An Association between HTRA1 and TGF-β2 in the Vitreous Humor of Patients with Chorioretinal Vascular Diseases., PMID:39274287
HTRA1-related cerebral small-vessel disease causes cerebral microbleeds on the brainstem surface., PMID:39270409
Redefining common and rare HTRA1 variants as risk factors for polyvascular disease., PMID:39196235
Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease., PMID:39196222
Identification of HTRA1, DPT and MXRA5 as potential biomarkers associated with osteoarthritis progression and immune infiltration., PMID:39148085
Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography., PMID:39128237
A Novel Lipopeptide-Functionalized Metal-Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway., PMID:39076893
Genetic Insights into Age-Related Macular Degeneration., PMID:39062052
Integrating Molecular Biology and Network Pharmacology to Analyze the Antidepressant Mechanism of Glycyrrhizaglabra., PMID:39041272
Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression., PMID:39028977
Rational correction of pathogenic conformational defects in HTRA1., PMID:39013852
For research use only. Not for human or drug use.
