Catalog No.
YHJ32201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu292-Gly528
Predicted molecular weight
29.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92674
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Follicle-stimulating hormone primary response protein, FSHPRH1, Interphase centromere complex protein 19, ICEN19, FSH primary response protein 1, LRPR1, Leucine-rich primary response protein 1, Centromere protein I, CENPI, CENP-I
The m6A reader YTHDF3 promotes TNBC progression by regulating CENPI stabilization., PMID:40406242
Artificial tethering of constitutive centromere-associated network proteins induces CENP-A deposition without Knl2 in DT40 cells., PMID:38319136
Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma., PMID:38232915
Pan-Cancer Analysis Reveals CENPI as a Potential Biomarker and Therapeutic Target in Adrenocortical Carcinoma., PMID:37465344
CENP-I directly targets centromeric DNA to support CENP-A deposition and centromere maintenance., PMID:36888657
Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer., PMID:36035209
The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis., PMID:35970865
Comprehensive Analysis of Centromere Protein Family Member Genes in Lung Adenocarcinoma., PMID:35695666
Upregulation of Centromere Proteins as Potential Biomarkers for Esophageal Squamous Cell Carcinoma Diagnosis and Prognosis., PMID:35496042
CTNNB1 gene mutation associated with neurodevelopmental disorder, microcephaly, and persistence of bilateral hyperplastic primary vitreous: A case report and literature review., PMID:35027145
Identification of potential druggable targets of cell cycle with small-molecule inhibitors in oral squamous cell carcinoma., PMID:34954767
Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and Migration., PMID:34617858
Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition., PMID:34206916
Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants., PMID:34039076
High expression levels of centromere protein A plus upregulation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway affect chemotherapy response and prognosis in patients with breast cancer., PMID:33841571
Structural insights into the intramolecular interactions of centromere protein CENP-I., PMID:32017295
Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin., PMID:31980633
Centromere protein I (CENPI) is a candidate gene for X-linked steroid sensitive nephrotic syndrome., PMID:31912435
Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells., PMID:31456134
High-resolution mapping of centromeric protein association using APEX-chromatin fibers., PMID:30445992
Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment., PMID:30407575
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response., PMID:29976630
CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion., PMID:29936263
CENP-C/H/I/K/M/T/W/N/L and hMis12 but not CENP-S/X participate in complex formation in the nucleoplasm of living human interphase cells outside centromeres., PMID:29509805
Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere., PMID:29439406
Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer., PMID:28977935
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere., PMID:28266506
Transcriptomic analysis of gene expression profiles of stomach carcinoma reveal abnormal expression of mitotic components., PMID:27923621
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly., PMID:26527398
Inner Kinetochore Protein Interactions with Regional Centromeres of Fission Yeast., PMID:26275423
Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing., PMID:25525168
Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases., PMID:25479423
The pseudo GTPase CENP-M drives human kinetochore assembly., PMID:25006165
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status., PMID:24862574
Identifying novel oncogenes: a machine learning approach., PMID:24402816
[Pathophysiology of antibody-associated diseases of the central nervous system]., PMID:23568168
The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly., PMID:23277427
A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint., PMID:22426531
Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases., PMID:21888900
The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase., PMID:20724819
Dual recognition of CENP-A nucleosomes is required for centromere assembly., PMID:20566683
Vertebrate kinetochore protein architecture: protein copy number., PMID:20548100
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations., PMID:20228811
The SUMO protease SENP6 is essential for inner kinetochore assembly., PMID:20212317
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N., PMID:19543270
Acceptor-photobleaching FRET analysis of core kinetochore and NAC proteins in living human cells., PMID:19533115
Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B., PMID:19412974
Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis., PMID:18362178
Dynamics of inner kinetochore assembly and maintenance in living cells., PMID:18347072
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates., PMID:18045986
For research use only. Not for human or drug use.
