Catalog No.
YHJ31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln420-Asp655
Predicted molecular weight
28.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92542
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0253, Nicastrin, NCSTN
Pathogenic variants in PSENEN and NCSTN genes cause 'follicular' Dowling-Degos disease: Report of five unrelated Indian families., PMID:40357971
A Systematic Review of Mendelian Pyoderma Gangrenosum: Clinical and Genetic Characteristics in 120 Published Patients., PMID:40329681
Serum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa., PMID:39878956
Upregulation of TLR2 in keratinocytes activates the MAPK pathway and plays a role in the pathogenesis of hidradenitis suppurativa., PMID:39732613
Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer., PMID:39719647
A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways., PMID:39645042
Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data., PMID:39175755
Dysregulation of Aquaporin-3 and Glyceryl Glucoside Restoring Action in Hidradenitis Suppurativa in Vitro Models., PMID:39166549
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
PLC-CN-NFAT1 signaling-mediated Aβ and IL-1β crosstalk synergistically promotes hippocampal neuronal damage., PMID:38749336
Unraveling the surface marker signature of cell-derived vesicles via proteome analysis and nanoparticle flow cytometry., PMID:38167556
Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma., PMID:38038618
Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds-A Preliminary Study., PMID:37760246
Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA., PMID:37691920
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa., PMID:37665193
NCSTN In-Frame Deletion in Maltese Patients With Hidradenitis Suppurativa., PMID:37494055
LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance., PMID:37492741
Discovery and Potential Functional Characterization of Long Noncoding RNAs Associated with Familial Acne Inversa with NCSTN Mutation., PMID:37490873
Hidradenitis suppurativa presents a methylome dysregulation capable to explain the pro-inflammatory microenvironment: Are these DNA methylations potential therapeutic targets?, PMID:37338327
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice., PMID:37252275
Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa., PMID:37013170
Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells., PMID:36909619
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)., PMID:36675001
Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing., PMID:36439123
Reduced expression of CXCL16/CXCR6 is involved in the pathogenesis of hidradenitis suppurativa., PMID:36394347
Chronic glucocorticoid exposure accelerates Aβ generation and neurotoxicity by activating calcium-mediated CN-NFAT1 signaling in hippocampal neurons in APP/PS1 mice., PMID:36075474
Effects of NCSTN Mutation on Hair Follicle Components in Mice., PMID:35843211
Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice., PMID:35777263
Alpha- and Gamma-Tocopherol Modulates the Amyloidogenic Pathway of Amyloid Precursor Protein in an in vitro Model of Alzheimer's Disease: A Transcriptional Study., PMID:35614968
Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis., PMID:35451473
A Novel NCSTN Mutation in a Three-Generation Chinese Family with Hidradenitis Suppurative., PMID:35368949
Evolutionary distinct roles of γ-secretase subunit nicastrin in zebrafish and humans., PMID:35016821
MicroRNA-Target Interaction Regulatory Network in Alzheimer's Disease., PMID:34945753
A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway., PMID:36654118
A novel mutation of the NCSTN gene in a Chinese hidradenitis suppurativa family with familial comedones as the main clinical manifestation., PMID:34860362
Two novel mutations of the γ-secretase genes in Chinese acne inversa (hidradenitis suppurativa)., PMID:34748240
Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling., PMID:34726809
Androgen receptor expression in the skin appendages of patients with acne inversa harboring a mutation in the γ-secretase gene NCSTN., PMID:34155878
A novel c.671_682del NCSTN variant in a family with hidradenitis suppurativa: a pilot study., PMID:33852739
Hidradenitis suppurativa associated with a novel NCSTN mutation and concomitant Klippel-Trenaunay syndrome., PMID:33814361
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes., PMID:33808143
Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage., PMID:33559291
γ-Secretase Genetics of Hidradenitis Suppurativa: A Systematic Literature Review., PMID:33333507
Ancient friends, revisited: Systematic review and case report of pyoderma gangrenosum-associated autoinflammatory syndromes., PMID:33305249
The deregulation of NOTCH pathway, inflammatory cytokines, and keratinization genes in two Dowling-Degos disease patients with hidradenitis suppurativa., PMID:33200913
Hidradenitis Suppurativa: Proposal of Classification in Two Endotypes with Two-Step Cluster Analysis., PMID:33171462
NCSTN Deficiency and Depigmentation: All About Tyrosinase?, PMID:33065108
Increased expression profile of NCSTN, Notch and PI3K/AKT3 in hidradenitis suppurativa., PMID:32978818
A Novel NCSTN Gene Mutation in a Japanese Family with Hidradenitis Suppurativa., PMID:32926179
The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells., PMID:32727592
For research use only. Not for human or drug use.
