Catalog No.
YHJ31201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro166-Met383
Predicted molecular weight
27.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92466
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Damage-specific DNA-binding protein 2, DNA damage-binding protein 2, UV-damaged DNA-binding protein 2, DDB2, UV-DDB 2, DDBb, DDB p48 subunit
Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid., PMID:40218305
Transcription blocking properties and transcription-coupled repair of N2-alkylguanine adducts as a model for aldehyde-induced DNA damage., PMID:40157541
Chlorogenic acid targets SIRT6 to relieve UVB - induced UV damage., PMID:40105999
KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer., PMID:39960727
Loss of DDB2 in type II diabetes mellitus induces dysregulated ubiquitination of KMT2A in lipid metabolism disorders., PMID:39798620
Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genes., PMID:39631147
LINC01320 facilitates cell proliferation and migration of ovarian cancer via regulating PURB/DDB2/NEDD4L/TGF-β axis., PMID:39482389
Recurrent hepatocellular carcinoma is associated with the enrichment of MYC targets gene sets, elevated high confidence deleterious mutations and alternative splicing of DDB2 and BRCA1 transcripts., PMID:39486583
Validation of a blood biomarker panel for machine learning-based radiation biodosimetry in juvenile and adult C57BL/6 mice., PMID:39396080
The histone demethylase JMJ27 acts during the UV-induced modulation of H3K9me2 landscape and facilitates photodamage repair., PMID:39367258
DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib., PMID:39333096
Identification of BBC3 as a novel indicator for predicting prostate cancer development and olaparib resistance., PMID:39331229
BAX and DDB2 as biomarkers for acute radiation exposure in the human blood ex vivo and non-human primate models., PMID:39164366
Investigation of Polymorphisms in Global Genome Repair Genes in Patients With Ovarian Cancer in the Turkish Population., PMID:39090825
Sequential post-translational modifications regulate damaged DNA-binding protein DDB2 function., PMID:39077792
Biomarkers for Radiation Biodosimetry and Correlation with Hematopoietic Injury in a Humanized Mouse Model., PMID:39034036
Cancer Stem Cells (CD44+/CD24-), RAD6, DDB2 Immunohistochemistry Expression and IHC-UNEDO Scoring System As Predictor of Ovarian Cancer Chemoresistance., PMID:38974750
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis., PMID:38860936
Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells., PMID:38773406
Alzheimer's Disease and Aging Association: Identification and Validation of Related Genes., PMID:38230733
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability., PMID:37943017
[DDB2-associated incidence of squamous cell carcinoma in Haflingers: risk minimization by genotyping]., PMID:37905572
UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence., PMID:37872164
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity., PMID:37716414
DDB2 and MDM2 genes are promising markers for radiation diagnosis and estimation of radiation dose independent of trauma and burns., PMID:37688632
Brazilian XP-E siblings carrying a novel DDB2 variant developed early-onset melanoma: a case report., PMID:37573316
Expression Profiling Reveals the Possible Involvement of the Ubiquitin-Proteasome Pathway in Abiotic Stress Regulation in Gracilariopsis lemaneiformis., PMID:37569689
Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate., PMID:37549410
p53-Dependent Cytoprotective Mechanisms behind Resistance to Chemo-Radiotherapeutic Agents Used in Cancer Treatment., PMID:37444509
Apoptotic effects of human amniotic fluid mesenchymal stem cells conditioned medium on human MCF-7 breast cancer cell line., PMID:37431479
Quantitative profiling of genes associated with cancer pathways in brain tumors., PMID:37353350
Candidate Gene Expression in Regional Population and Its Relevance for Radiation Triage., PMID:37253332
PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repair., PMID:37142958
MBD2 facilitates tumor metastasis by mitigating DDB2 expression., PMID:37142578
Effects of Neutron and Gamma Rays Combined Irradiation on the Transcriptional Profile of Human Peripheral Blood., PMID:37014889
UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties., PMID:36971122
Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE)., PMID:36861323
Aristophania vespae gen. nov., sp. nov., isolated from wasps, is related to Bombella and Oecophyllibacter, isolated from bees and ants., PMID:36749681
The Role of Alternative Splicing Factors, DDB2-Related Ageing and DNA Damage Repair in the Progression and Prognosis of Stomach Adenocarcinoma Patients., PMID:36672781
Machine learning approach for quantitative biodosimetry of partial-body or total-body radiation exposures by combining radiation-responsive biomarkers., PMID:36653416
The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer., PMID:36636074
DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy., PMID:36568213
Four Genes Predictive for the Severity of Hematological Damage Reveal a Similar Response after X Irradiation and Chemotherapy., PMID:36480042
Identification and validation of ubiquitin-proteasome system related genes as a prognostic signature for papillary renal cell carcinoma., PMID:36385010
A protein with broad functions: damage-specific DNA-binding protein 2., PMID:36190612
Combining Phenotypes of Nucleotide Excision Repair Pathway to Predict the Risk of Head and Neck Squamous Cell Carcinomas in a Chinese Population., PMID:36118674
Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study., PMID:36068491
TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells., PMID:35944360
Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair., PMID:35940372
Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex., PMID:35938868
For research use only. Not for human or drug use.
