Catalog No.
YHJ29601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu174-Ala383
Predicted molecular weight
50.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WUM4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95, AIP1, ALIX, KIAA1375, PDCD6IP, Programmed cell death 6-interacting protein, PDCD6-interacting protein
TDCPP disrupts ALG-2/ALIX-mediated ESCRT-III recruitment: Implications for lysosomal membrane repair and neurotoxicity., PMID:40425064
AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy., PMID:40320752
Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes., PMID:39976236
Calcium release from damaged lysosomes triggers stress granule formation for cell survival., PMID:39962896
A Novel HTNV Budding Inhibitor Interferes the Interaction Between Viral Glycoprotein and Host ESCRT Accessory Protein ALIX., PMID:39868900
A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer., PMID:39693144
Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity., PMID:39495296
NEDD4 family ubiquitin ligase AIP4 interacts with Alix to enable HBV naked capsid egress in an Alix ubiquitination-independent manner., PMID:39259704
Investigating Neuroplasticity Changes Reflected by BDNF Levels in Astrocyte-Derived Extracellular Vesicles in Patients with Depression., PMID:39246428
Differential response of placental cells to high D-glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras-related protein RAB-7A., PMID:38938672
COPII with ALG2 and ESCRTs control lysosome-dependent microautophagy of ER exit sites., PMID:38593803
Essential role of Alix in regulating cardiomyocyte exosome biogenesis under physiological and stress conditions., PMID:38593639
Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication., PMID:38403678
Tracing the pathways and mechanisms involved in medicinal uses of flaxseed with computational methods and bioinformatics tools., PMID:38283897
SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer., PMID:37925421
The role of ATG5 beyond Atg8ylation and autophagy., PMID:37876292
Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes., PMID:37794117
UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission., PMID:37439191
Inhibition mechanism of testis-expressed gene 14 (TEX14) in cytokinetic abscission: Well-tempered metadynamics simulation studies., PMID:37409705
ALIX promotes cell migration and invasion of head and neck squamous cell carcinoma by regulating the expression of MMP9, MMP14, VEGF-C., PMID:37086494
A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer., PMID:36993200
miR‑363‑3p attenuates the oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury in vitro by targeting PDCD6IP., PMID:36052865
Distinct functions of dimeric and monomeric scaffold protein Alix in regulating F-actin assembly and loading of exosomal cargo., PMID:36030822
In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair., PMID:35994655
Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients., PMID:35821008
Alix is required for activity-dependent bulk endocytosis at brain synapses., PMID:35658004
Biophysical and functional study of CRL5Ozz, a muscle specific ubiquitin ligase complex., PMID:35551201
One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant., PMID:35543580
Isolation methods of large and small extracellular vesicles derived from cardiovascular progenitors: A comparative study., PMID:34968647
Effects of an acute exercise bout in hypoxia on extracellular vesicle release in healthy and prediabetic subjects., PMID:34907783
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation., PMID:34882480
Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection., PMID:34851141
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform., PMID:34817906
Proximity-Labeling Reveals Novel Host and Parasite Proteins at the Toxoplasma Parasitophorous Vacuole Membrane., PMID:34749525
Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment., PMID:34730397
Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX., PMID:34688656
Isolation and Identification of Long Non-Coding RNAs in Exosomes Derived from the Serum of Colorectal Carcinoma Patients., PMID:34571795
A comprehensive analysis of different gene classes in pancreatic cancer: SIGLEC15 may be a promising immunotherapeutic target., PMID:34515878
Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding., PMID:34287046
Isolation of extracellular vesicles from byproducts of cheesemaking by tangential flow filtration yields heterogeneous fractions of nanoparticles., PMID:34218910
Proteome characterisation of extracellular vesicles isolated from heart., PMID:33861516
HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients., PMID:33785040
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment., PMID:33767277
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells., PMID:33756122
Proteomic profile of melanoma cell-derived small extracellular vesicles in patients' plasma: a potential correlate of melanoma progression., PMID:33613873
Descriptive analysis of Fibulin-3 and the extracellular vesicle marker, Alix, in drusen from a small cohort of postmortem human eyes., PMID:33387484
Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis., PMID:33154436
ESCRT-III controls nuclear envelope deformation induced by progerin., PMID:33139753
Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes., PMID:33058236
Abrogating ALIX Interactions Results in Stuttering of the ESCRT Machinery., PMID:32948012
For research use only. Not for human or drug use.
