Catalog No.
YHJ29401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr31-Ala386
Predicted molecular weight
39.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WUJ3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CEMIP, Cell migration-inducing and hyaluronan-binding protein, KIAA1199
New molecules indispensable for hyaluronan degradation, HYBID (CEMIP/KIAA1199) and TMEM2 (CEMIP2): Differential roles in physiological and pathological non-neoplastic conditions., PMID:40500182
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP., PMID:40490703
Upregulated CEMIP promotes intervertebral disc degeneration via AP-1-mediated change in chromatin accessibility., PMID:40400122
Extracellular Vesicle-Associated Angiopoietin-2 and Cell Migration-Inducing Protein in Lung Cancer Progression and Brain Metastases., PMID:40190907
KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism., PMID:40169533
MARCH8 ubiquitinates and degrades CEMIP to induce colorectal cancer cell ferroptosis through inactivating PI3K/AKT pathway., PMID:40107011
Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis., PMID:40056245
Deletion of smooth muscle ZFP36 promotes neointimal hyperplasia in mice., PMID:39890944
Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer., PMID:39800687
The crucial role of CEMIP in cancer metastasis: Mechanistic insights and clinical implications., PMID:39758005
Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation., PMID:39658708
Bioinformatics analysis of colorectal cancer transcriptomic data reveals novel prognostic signature and potential biomarker genes., PMID:39644158
Citrus rhoifolin alleviated DSS-induced acute colitis by activating CEMIP/SLC7A11-mediated cystine uptake and inhibiting epithelial ferroptosis., PMID:39570404
Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts., PMID:39504052
CEMIP induces TGF-β/Smad signaling to promote keloid development by binding to SPARC., PMID:39481283
Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation., PMID:39454959
Expression and significance of CEMIP and CYP11B2 in serum in women with foetal growth restriction., PMID:39218008
Silencing of KIAA1429, a N6-methyladenine methyltransferase, inhibits the progression of colon adenocarcinoma via blocking the hypoxia-inducible factor 1 signalling pathway., PMID:39215765
KIAA1199/CEMIP knockdown attenuates cardiac remodeling post myocardial infarction by activating TSP4 pathway in mice., PMID:39173890
IGJ depletion suppresses proliferation, inflammation, and motility of rheumatoid arthritis fibroblast-like synoviocytes via targeting NF-κB pathway., PMID:39091178
Genetic Deficiencies of Hyaluronan Degradation., PMID:39056785
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module., PMID:39043968
CCDC88C, an O-GalNAc glycosylation substrate of GALNT6, drives breast cancer metastasis by promoting c-JUN-mediated CEMIP transcription., PMID:38971758
Molecular Signatures for Microbe-Associated Colorectal Cancers., PMID:38853996
Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3., PMID:38844132
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway., PMID:38664616
miRNA-383-5p Regulated Migration and Invasion of Tumor Cells by Inhibiting NCKAP1 Expression in Gastric Cancer., PMID:38625593
Transcription factor KLF9 inhibits the proliferation, invasion, and migration of pancreatic cancer cells by repressing KIAA1522., PMID:38520660
The role of CEMIP in cancers and its transcriptional and post-transcriptional regulation., PMID:38390387
Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model., PMID:38308210
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis., PMID:38289873
ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT., PMID:38199493
Single-cell RNA Sequencing Analysis Reveals the Role of Cancerassociated Fibroblasts in Skin Melanoma., PMID:38173195
Acute brain injury increases pulmonary capillary permeability via sympathetic activation-mediated high fluid shear stress and destruction of the endothelial glycocalyx layer., PMID:38092346
Adipocyte Glucocorticoid Receptor Inhibits Immune Regulatory Genes to Maintain Immune Cell Homeostasis in Adipose Tissue., PMID:37738419
Chitosan oligosaccharide suppresses osteosarcoma malignancy by inhibiting CEMIP via the PI3K/AKT/mTOR pathway., PMID:37668818
Research on the biological mechanism and potential application of CEMIP., PMID:37662915
A comprehensive analysis of biomarkers associated with synovitis and chondrocyte apoptosis in osteoarthritis., PMID:37545537
The hyaluronan metabolism in the UV-irradiated human epidermis and the relevance of in vitro epidermal models., PMID:37443444
BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial infarction model by upregulating AP-1/CEMIP expression., PMID:37313693
Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression., PMID:37196767
Inhibiting Heat Shock Protein 90 Attenuates Nucleus Pulposus Fibrosis and Pathologic Angiogenesis Induced by Macrophages via Down-Regulating Cell Migration-Inducing Protein., PMID:37088454
FAIM2 is correlated with metastasis of medulloblastoma through bioinformatics analysis., PMID:37083768
KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration., PMID:37037828
Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agents., PMID:36991484
CEMIP-mediated hyaluronan metabolism facilitates SCLC metastasis by activating TLR2/c-Src/ERK1/2 axis., PMID:36931608
Gene Co-Expression Network Analysis Reveals the Hub Genes and Key Pathways Associated with Resistance to Salmonella Enteritidis Colonization in Chicken., PMID:36902251
Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood-brain barrier and treatment strategies., PMID:36897508
CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway., PMID:36849460
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis., PMID:36746261
For research use only. Not for human or drug use.
