Catalog No.
YHJ29101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp239-Asn449
Predicted molecular weight
26.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WU20
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FGFR substrate 2, FRS2, Fibroblast growth factor receptor substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1
Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development., PMID:40327534
Oncogenic and Immunological Roles of FRS2 and its Potential Value in Retroperitoneal Liposarcoma: from Bioinformatics Analysis to Clinicopathological Evidence., PMID:40225873
Unveiling an unexpected redox regulation of the folding, function and inhibition in the phosphotyrosine binding domain of FRS2., PMID:40203902
[Alveolar rhabdomyosarcoma with amplification of 12q15 region including MDM2 and FRS2 genes: report of a case]., PMID:39762180
Inhibiting FGFR by toadflax reverses erlotinib resistance in nonsmall cell lung cancer., PMID:39724548
Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development., PMID:39484547
Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort., PMID:39342401
Hsa_circ_0007765 Promotes Platelet-Derived Growth Factor-BB-Induced Proliferation and Migration of Human Aortic Vascular Smooth Muscle Cells in Atherosclerosis., PMID:39126580
A convenient broad-host counterselectable system endowing rapid genetic manipulations of Kluyveromyces lactis and other yeast species., PMID:39061053
The combination of gemcitabine plus an anti-FGFR inhibitor can have a synergistic antitumor effect on FGF-activating cholangiocarcinoma., PMID:38801887
Ligand bias underlies differential signaling of multiple FGFs via FGFR1., PMID:38568193
Hsa_circ_0032389 Enhances Proliferation and Migration in PDGF-BB-Induced Human Aortic Vascular Smooth Muscle Cells., PMID:38378972
Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2., PMID:38376663
FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma., PMID:38159618
Tephrosin Suppresses the Chemoresistance of Paclitaxel-Resistant Ovarian Cancer via Inhibition of FGFR1 Signaling Pathway., PMID:38137377
Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations., PMID:38001614
The Comparison of Commercial Serum-Free Media for Hanwoo Satellite Cell Proliferation and the Role of Fibroblast Growth Factor 2., PMID:37969322
Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity., PMID:37875162
IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway., PMID:37686528
Pooled ctDNA analysis of MONALEESA phase III advanced breast cancer trials., PMID:37673211
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands., PMID:37543351
Expression of fibroblast growth factor receptor substrate 2 (FRS2) in primary retroperitoneal liposarcoma and its clinical implications., PMID:37458641
FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development., PMID:37421147
Clinical and Genomic Characteristics of Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors., PMID:37289194
Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression., PMID:37264620
Expression and Purification of FGFR1-Fc Fusion Protein and Its Effects on Human Lung Squamous Carcinoma., PMID:37160564
Analysis Of Common Somatic Mutations In Colorectal Carcinoma And Associated Dysregulated Pathwaysarts., PMID:36849394
Aggressive High-grade Uterine Sarcoma Harboring MEIS1-NCOA2 Fusion and Amplification of Multiple 12q13-15 Genes: A Case Report With Morphologic, Immunohistochemical, and Molecular Analysis., PMID:36811835
Inflammatory cytokine-enriched microenvironment plays key roles in the development of breast cancers., PMID:36704829
Targeting PEA3 transcription factors to mitigate small cell lung cancer progression., PMID:36509998
Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth., PMID:36495366
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action., PMID:36410439
TRIM44 Promotes Endometrial Carcinoma Progression by Activating the FRS2 Signalling Pathway., PMID:36387361
A novel small molecule RK-019 inhibits FGFR2-amplification gastric cancer cell proliferation and induces apoptosis in vitro and in vivo., PMID:36210834
Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response., PMID:36031605
Infigratinib (BGJ 398), a Pan-FGFR Inhibitor, Targets P-Glycoprotein and Increases Chemotherapeutic-Induced Mortality of Multidrug-Resistant Tumor Cells., PMID:35327403
BLU-554, A selective inhibitor of FGFR4, exhibits anti-tumour activity against gastric cancer in vitro., PMID:35093636
Circ_0002984 Enhances Growth, Invasion, and Migration in PDGF-bb-Induced Vascular Smooth Muscle Cells Through miR-379-5p/FRS2 Axis., PMID:34882114
Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity., PMID:34840970
Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data., PMID:34696768
Mutational characteristics of bone metastasis of lung cancer., PMID:34488370
Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts., PMID:34414852
Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis., PMID:34159479
Identification and In-Depth Analysis of the Novel FGFR2-NDC80 Fusion in a Cholangiocarcinoma Patient: Implication for Therapy., PMID:33800328
Co-dependency for MET and FGFR1 in basal triple-negative breast cancers., PMID:33772015
Kaempferol alleviates human endothelial cell injury through circNOL12/miR-6873-3p/FRS2 axis., PMID:33761622
Clinical Application of Chromosome Microarray Analysis in the Diagnosis of Lipomatous Tumors., PMID:33734108
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma., PMID:33674622
LncRNA SNHG6 Promotes Wilms' Tumor Progression Through Regulating miR-429/FRS2 Axis., PMID:33481659
MicroRNA expression profiling reveals potential roles for microRNA in the liver during pigeon (Columba livia) development., PMID:33248553
For research use only. Not for human or drug use.
