Catalog No.
YHJ27801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val174-Ala523
Predicted molecular weight
41.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TD30
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alanine aminotransferase 2, Glutamic--pyruvic transaminase 2, AAT2, ALT2, Glutamate pyruvate transaminase 2, GPT 2, Glutamic--alanine transaminase 2, GPT2
Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression., PMID:40416363
Potential Biomarkers and Therapeutic Targets in Hepatitis B Virus-related Acute Liver Failure: Interplay of the Ferroptosis, Autophagy and Immune Responses., PMID:39991755
Identifying Hub Genes and Pathways in Pancreatic Ductal Adenocarcinoma (PAAD): A comprehensive in silico study., PMID:39911529
Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy., PMID:39904774
In vitro bisphenol A impairs testicular energy metabolism and spermatogenesis through nuclear estrogen receptors activation in zebrafish., PMID:39855486
LNC_000280 could be a new positive factor in the proliferation and differentiation of myoblasts: A prospective study., PMID:39602431
The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer., PMID:39488663
Generative AI Models for the Protein Scaffold Filling Problem., PMID:39441716
Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis., PMID:39315548
Post-translational modification prediction via prompt-based fine-tuning of a GPT-2 model., PMID:39107330
Comprehensive Research on Druggable Proteins: From PSSM to Pre-Trained Language Models., PMID:38674091
System analysis based on glutamine catabolic-related enzymes identifies GPT2 as a novel immunotherapy target for lung adenocarcinoma., PMID:37657356
Integrated analysis of transcriptome and proteome for exploring mechanism of promoting proliferation of equine satellite cells associated with leucine., PMID:37633218
Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis., PMID:37414778
Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC., PMID:37287397
Saccharomyces cerevisiae Δ9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1., PMID:37269945
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis., PMID:36923530
Targeted metabolomics analysis identified the role of FOXA1 in the change in glutamate-glutamine metabolic pattern of BaP malignantly transformed 16HBE cells., PMID:36702312
SLAM-seq reveals early transcriptomic response mechanisms upon glutamine deprivation in Chinese hamster ovary cells., PMID:36575109
SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner., PMID:36527113
Transcriptional profiles and common genes link lung cancer with the development and severity of COVID-19., PMID:36379381
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia., PMID:36306790
Glucose-6-P/phosphate translocator2 mediates the phosphoglucose-isomerase1-independent response to microbial volatiles., PMID:36111879
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth., PMID:36010673
Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus., PMID:35908744
Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells., PMID:35847893
Paternal uniparental disomy of chromosome 16 resulting in homozygosity of a GPT2 mutation causes intellectual and developmental disability., PMID:35793769
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma., PMID:35499760
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2., PMID:35196498
A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer., PMID:35071228
Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression., PMID:35021150
Cellular and Molecular Phenotypes of pConsensus Peptide (pCons) Induced CD8+ and CD4+ Regulatory T Cells in Lupus., PMID:34867947
PIK3CA mutation affects the proliferation of colorectal cancer cells through the PI3K-MEK/PDK1-GPT2 pathway., PMID:34751411
Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo., PMID:34519342
Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol., PMID:34389946
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis., PMID:34267342
iTRAQ-based quantitative proteomic analysis reveals the toxic mechanism of diclofenac sodium on the kidney of broiler chicken., PMID:34229076
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness., PMID:33910646
[The Influence of Glutamic Pyruvate Transaminase 2 to Biological Characteristics of Acute Myeloid Leukemia Cell HL-60]., PMID:33812407
Demyelinating motor neuropathy associated with a homozygous GPT2 pathogenic variant., PMID:33501685
Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy., PMID:33368291
The Arabidopsis Plastidial Glucose-6-Phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum., PMID:32111666
A novel missense variant in GPT2 causes non-syndromic autosomal recessive intellectual disability in a consanguineous Iranian family., PMID:31978613
GPT2 mutations in autosomal recessive developmental disability: extending the clinical phenotype and population prevalence estimates., PMID:31471722
Phosphorylation of the lipid droplet localized glycerol‑3‑phosphate acyltransferase Gpt2 prevents a futile triacylglycerol cycle in yeast., PMID:31421179
SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis., PMID:30858360
Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism., PMID:30765862
The role of HEXOKINASE1 in Arabidopsis leaf growth., PMID:30511331
A PDX1-ATF transcriptional complex governs β cell survival during stress., PMID:30174228
GPT2 mutations cause developmental encephalopathy with microcephaly and features of complicated hereditary spastic paraplegia., PMID:29882329
For research use only. Not for human or drug use.
