Catalog No.
YHJ27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu560
Predicted molecular weight
89.05 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TCG1
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CIP2A, Protein CIP2A, Cancerous inhibitor of PP2A, p90 autoantigen, KIAA1524
Note
For research use only.
Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein family member Survivin., PMID:36581205
Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression., PMID:36690227
Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study., PMID:36702627
Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer., PMID:36705466
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A., PMID:36854761
Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin., PMID:36908323
From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer., PMID:36911405
Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes., PMID:36999590
The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma., PMID:37048102
Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A., PMID:37097392
cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization., PMID:37127088
Mitotic clustering of pulverized chromosomes from micronuclei., PMID:37165191
Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies., PMID:37196541
Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition., PMID:37289585
Mitotic tethering enables inheritance of shattered micronuclear chromosomes., PMID:37316668
Celastrol impairs tumor growth by modulating the CIP2A-GSK3β-MCL-1 axis in gastric cancer cells., PMID:37470692
A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis., PMID:37582160
CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response., PMID:37793965
Emerging roles of the CIP2A-TopBP1 complex in genome integrity., PMID:37829116
CIP2A interacts with AKT1 to promote the malignant biological behaviors of oral squamous cell carcinoma by upregulating the GSK‑3β/β‑catenin pathway., PMID:37840566
c-MYC-dependent transcriptional inhibition of autophagy is implicated in cisplatin sensitivity in HPV-positive head and neck cancer., PMID:37925449
DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved., PMID:38139431
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against triple negative breast cancer (TNBC)., PMID:38166612
CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer., PMID:38321019
Broken chromosomes heading into mitosis: More than one way to patch a flat tire., PMID:38477879
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma., PMID:38600440
Degradation-Based Protein Profiling: A Case Study of Celastrol., PMID:38664976
Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities., PMID:38710586
Loss of function variant in CIP2A associated with female infertility with early embryonic arrest and fragmentation., PMID:38734318
Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling., PMID:38819231
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development., PMID:38826439
Sideroflexin-1 promotes progression and sensitivity to lapatinib in triple-negative breast cancer by inhibiting TOLLIP-mediated autophagic degradation of CIP2A., PMID:38849012
Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m6A Translation and Gastric Cancer Progression., PMID:38887155
Anti-Leukemic Effects of Small Molecule Inhibitor of c-Myc (10058-F4) on Chronic Myeloid Leukemia Cells., PMID:38918657
Sensitive Detection of Oral Leukoplakia: Analyzing P90 Biomarkers in Saliva and Tissue., PMID:38920585
Paradoxical action of PP2A inhibition and its potential for therapeutic sensitization., PMID:39150149
Protein phosphatase 2A activators under investigation for smoking-related chronic obstructive pulmonary disease and related disorders., PMID:39394816
Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor-mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation., PMID:39399646
PP2A activation overcomes leptomeningeal dissemination in group 3 medulloblastoma., PMID:39419284
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development., PMID:39443726
CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway., PMID:39615212
Novel BRCA1-PLK1-CIP2A axis orchestrates homologous recombination-mediated DNA repair to maintain chromosome integrity during oocyte meiosis., PMID:39657788
Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis., PMID:39739023
Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies., PMID:39963741
Circular RNA Vav3 mediated ALV-J inhibition of autophagy by modulating the gga-miR-375/CIP2A axis and activating AKT., PMID:39987600
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway., PMID:40017141
A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC., PMID:40354992
High Expression of CIP2A Can Promote the Proliferation, Migration, and Epithelial-Mesenchymal Transition of Diffuse Large B-Cell Lymphoma Cells., PMID:40459191
[Corrigendum] Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A., PMID:40476554
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP., PMID:40490703
For research use only. Not for human or drug use.
