Catalog No.
YHJ27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu560
Predicted molecular weight
89.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TCG1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CIP2A, Protein CIP2A, Cancerous inhibitor of PP2A, p90 autoantigen, KIAA1524
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP., PMID:40490703
[Corrigendum] Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A., PMID:40476554
High Expression of CIP2A Can Promote the Proliferation, Migration, and Epithelial-Mesenchymal Transition of Diffuse Large B-Cell Lymphoma Cells., PMID:40459191
A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC., PMID:40354992
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway., PMID:40017141
Circular RNA Vav3 mediated ALV-J inhibition of autophagy by modulating the gga-miR-375/CIP2A axis and activating AKT., PMID:39987600
Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies., PMID:39963741
Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis., PMID:39739023
Novel BRCA1-PLK1-CIP2A axis orchestrates homologous recombination-mediated DNA repair to maintain chromosome integrity during oocyte meiosis., PMID:39657788
CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway., PMID:39615212
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development., PMID:39443726
PP2A activation overcomes leptomeningeal dissemination in group 3 medulloblastoma., PMID:39419284
Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor-mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation., PMID:39399646
Protein phosphatase 2A activators under investigation for smoking-related chronic obstructive pulmonary disease and related disorders., PMID:39394816
Paradoxical action of PP2A inhibition and its potential for therapeutic sensitization., PMID:39150149
Sensitive Detection of Oral Leukoplakia: Analyzing P90 Biomarkers in Saliva and Tissue., PMID:38920585
Anti-Leukemic Effects of Small Molecule Inhibitor of c-Myc (10058-F4) on Chronic Myeloid Leukemia Cells., PMID:38918657
Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m6A Translation and Gastric Cancer Progression., PMID:38887155
Sideroflexin-1 promotes progression and sensitivity to lapatinib in triple-negative breast cancer by inhibiting TOLLIP-mediated autophagic degradation of CIP2A., PMID:38849012
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development., PMID:38826439
Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling., PMID:38819231
Loss of function variant in CIP2A associated with female infertility with early embryonic arrest and fragmentation., PMID:38734318
Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities., PMID:38710586
Degradation-Based Protein Profiling: A Case Study of Celastrol., PMID:38664976
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma., PMID:38600440
Broken chromosomes heading into mitosis: More than one way to patch a flat tire., PMID:38477879
CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer., PMID:38321019
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against triple negative breast cancer (TNBC)., PMID:38166612
DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved., PMID:38139431
c-MYC-dependent transcriptional inhibition of autophagy is implicated in cisplatin sensitivity in HPV-positive head and neck cancer., PMID:37925449
CIP2A interacts with AKT1 to promote the malignant biological behaviors of oral squamous cell carcinoma by upregulating the GSK‑3β/β‑catenin pathway., PMID:37840566
Emerging roles of the CIP2A-TopBP1 complex in genome integrity., PMID:37829116
CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response., PMID:37793965
A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis., PMID:37582160
Celastrol impairs tumor growth by modulating the CIP2A-GSK3β-MCL-1 axis in gastric cancer cells., PMID:37470692
Mitotic tethering enables inheritance of shattered micronuclear chromosomes., PMID:37316668
Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition., PMID:37289585
Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies., PMID:37196541
Mitotic clustering of pulverized chromosomes from micronuclei., PMID:37165191
cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization., PMID:37127088
Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A., PMID:37097392
The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma., PMID:37048102
Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes., PMID:36999590
From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer., PMID:36911405
Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin., PMID:36908323
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A., PMID:36854761
Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer., PMID:36705466
Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study., PMID:36702627
Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression., PMID:36690227
Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein family member Survivin., PMID:36581205
For research use only. Not for human or drug use.
