Catalog No.
YHJ26101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu31-Glu184
Predicted molecular weight
20.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NFZ5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A20-binding inhibitor of NF-kappa-B activation 2, ABIN2, ABIN-2, FLIP1, TNFAIP3-interacting protein 2, TNIP2, Fetal liver LKB1-interacting protein
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis., PMID:39827378
Icariside II Alleviates Chondrocyte Inflammatory Injury by Inhibiting the TNIP2/NF-κB Pathway., PMID:39775470
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases., PMID:39562788
PARVB deficiency alleviates cisplatin-induced tubular injury by inhibiting TAK1 signaling., PMID:39235496
Propofol Ameliorates Spinal Cord Injury Process by Mediating miR-672-3p/TNIP2 Axis., PMID:38379038
ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression., PMID:38009796
TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation., PMID:37904691
Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats., PMID:37329819
Aberrant Histone Modification of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 in Major Depressive Disorder., PMID:37148522
TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study., PMID:37085111
Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis., PMID:36749097
Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis., PMID:36503346
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis., PMID:36333501
ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis., PMID:36034412
Long non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis., PMID:35443851
Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway., PMID:35433535
17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze., PMID:34919286
Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through Regulation of the TLR4/MyD88/NF-κB Pathway., PMID:34267521
A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance., PMID:34031190
Novel TNIP2 and TRAF2 Variants Are Implicated in the Pathogenesis of Pulmonary Arterial Hypertension., PMID:33996849
TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder., PMID:33932528
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer., PMID:33542218
A novel TNIP2-RET fusion identified in a patient with mucinous adenocarcinoma of the lung., PMID:33478856
Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia., PMID:33206936
Role of microRNA-15a-5p/TNFAIP3-interacting protein 2 axis in acute lung injury induced by traumatic hemorrhagic shock., PMID:32934667
ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease., PMID:32599618
microRNA-15a-5p participates in sepsis by regulating the inflammatory response of macrophages and targeting TNIP2., PMID:32256793
Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice., PMID:31694920
The clinical responses of TNIP2-ALK fusion variants to crizotinib in ALK-rearranged lung adenocarcinoma., PMID:31521978
ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation., PMID:31401161
Elevated TNIP3 mRNA Expression in TNF-α-Secreting Cells from Patients with Major Depressive Disorder., PMID:31307045
Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis., PMID:31033479
Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma., PMID:30720079
Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis., PMID:30617349
NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses., PMID:30510071
Hydroxychavicol sensitizes imatinib-resistant chronic myelogenous leukemia cells to TRAIL-induced apoptosis by ROS-mediated IAP downregulation., PMID:30418193
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism., PMID:30355787
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner., PMID:30341420
A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation., PMID:30337469
A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival., PMID:29930103
TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway., PMID:29709475
Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB., PMID:29654213
Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate., PMID:29229763
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC., PMID:29203883
Protective Role of TNIP2 in Myocardial Injury Induced by Acute Pancreatitis and Its Mechanism., PMID:29176547
Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection., PMID:29084252
ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation., PMID:28935578
The effects of miRNA-1180 on suppression of pancreatic cancer., PMID:28670370
Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-κB, ABIN-2., PMID:27916521
Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1., PMID:27807192
For research use only. Not for human or drug use.
