Catalog No.
YHJ25501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys30-Pro283
Predicted molecular weight
30.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NF91
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear envelope spectrin repeat protein 1, Myocyte nuclear envelope protein 1, KIAA1262, KIAA1756, KASH domain-containing protein 1, KIAA0796, SYNE1, KASH1, Syne-1, Nesprin-1, Enaptin, C6orf98, MYNE1, Myne-1, Synaptic nuclear envelope protein 1
Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments., PMID:40276214
ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation., PMID:40220918
Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology., PMID:40208950
Intronic SYNE1 Gene Novel Variant Associated with Myocardial Infarction in Young People with a Family History of Premature Atherosclerosis: A Case-Control Study in the Polish Population., PMID:40076866
Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma., PMID:40044946
GWAS-Significant Loci and Uterine Fibroids Risk: Analysis of Associations, Gene-Gene and Gene-Environmental Interactions., PMID:39736018
LRP1B associated with immune cell infiltration influenced the efficacy of immunotherapy in colorectal cancer patients., PMID:39532036
Breast cancer genomic analyses reveal genes, mutations, and signaling networks., PMID:39496981
Decitabine Enhances Sorafenib Sensitivity in Renal Cell Carcinoma by Promoting BIN1 and SYNE1 Expressions., PMID:39473430
Challenging Diagnosis of a Patient with Two Novel Variants in the SYNE1 Gene., PMID:39409170
Unraveling the nexus of nesprin in dilated cardiomyopathy: From molecular insights to therapeutic prospects., PMID:39396640
[Rare forms of autosomal recessive spinocerebellar ataxia associated with mutations in the ANO10 (ATX-ANO10) and SYNE1 (ATX-SYNE1) genes]., PMID:39269294
Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps., PMID:39252008
DUSP6 protein action and related hub genes prevention of sepsis-induced lung injury were screened by WGCNA and Venn., PMID:39197622
Clinical and Genetic Heterogeneity of Nuclear Envelopathy Related Muscular Dystrophies in an Indian Cohort., PMID:39058449
Mutational and transcriptional profile predicts the prognosis of stage IV gastric cancer - Prognostic factors for metastatic gastric cancer., PMID:39043541
Perfluorooctanesulfonic acid (PFOS) induced cancer related DNA methylation alterations in human breast cells: A whole genome methylome study., PMID:39032741
Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes., PMID:38977697
DcR3-associated risk score: correlating better prognosis and enhanced predictive power in colorectal cancer., PMID:38890197
Exome sequencing implicates ancestry-related Mendelian variation at SYNE1 in childhood-onset essential hypertension., PMID:38716726
Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice., PMID:38521778
Nesprin1 Deficiency Is Associated with Poor Prognosis of Renal Cell Carcinoma and Resistance to Sunitinib Treatment., PMID:38442705
Whole-exome sequencing has revealed novel genetic characteristics in intracranial germ cell tumours in the Chinese., PMID:38409885
Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer., PMID:38376070
Unraveling the genetic landscape of undiagnosed cerebellar ataxia in Brazilian patients., PMID:38145611
A Case Report of SYNE1 Deficiency-Mimicking Mitochondrial Disease and the Value of Pangenomic Investigations., PMID:38136976
miR-17-92 cluster-BTG2 axis regulates B-cell receptor signaling in mantle cell lymphoma., PMID:38050664
Co-mutation of TP53 and TTN is Correlated with the Efficacy of Immunotherapy in Lung Squamous Cell Carcinoma., PMID:37904553
Impact of Genomic Alterations on the Clinical Outcome of Patients With Hepatitis B-related Hepatocellular Carcinoma Receiving Curative Surgery: A Retrospective Cohort Study., PMID:37772577
SYNE1 Mutation Is Associated with Increased Tumor Mutation Burden and Immune Cell Infiltration in Ovarian Cancer., PMID:37762518
Role of ICAM1 in tumor immunity and prognosis of triple-negative breast cancer., PMID:37671167
Single cell RNA analysis of the left-right organizer transcriptome reveals potential novel heterotaxy genes., PMID:37393374
Identification of Somatic Mutations in Plasma Cell-Free DNA from Patients with Metastatic Oral Squamous Cell Carcinoma., PMID:37373553
Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma., PMID:37340028
Mutational landscape of primary spinal cord astrocytoma., PMID:37114614
Novel Compound Heterozygous Mutations in the SYNE1 Gene in a Taiwanese Family: A Case Report and Literature Review., PMID:37096302
Functional differentiation of the ovine preadipocytes -insights from gene expression profiling., PMID:36952056
High-fiber-diet-related metabolites improve neurodegenerative symptoms in patients with obesity with diabetes mellitus by modulating the hippocampal-hypothalamic endocrine axis., PMID:36733447
High diagnostic yield of targeted next-generation sequencing panel as a first-tier molecular test for the patients with myopathy or muscular dystrophy., PMID:36575883
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary., PMID:36552829
SYNE1-ataxia: clinicopathologic features of an autopsied patient with novel compound heterozygous mutations., PMID:36525394
Trio-based exome sequencing broaden the genetic spectrum in keratoconus., PMID:36502923
A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions., PMID:36457050
Family-based exome sequencing identifies candidate genes related to keratoconus in Chinese families., PMID:36118869
Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways., PMID:35962262
Comprehensive Analysis of HMCN1 Somatic Mutation in Clear Cell Renal Cell Carcinoma., PMID:35886066
First report of SYNE1 arthrogryposis multiplex congenita from Saudi Arabia with a novel mutation: a case report., PMID:35739559
Erythropoietin promotes the differentiation of fetal neural stem cells into glial cells via the erythropoietin receptor-β common receptor/Syne-1/H3K9me3 pathway., PMID:35715965
Analysis of recurrent molecular alterations in phyllodes tumour of breast: insights into prognosis and pathogenesis., PMID:35691725
The potential, analysis and prospect of ctDNA sequencing in hepatocellular carcinoma., PMID:35602894
For research use only. Not for human or drug use.
