Catalog No.
YHJ24801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu21-Ala493
Predicted molecular weight
55.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NER5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activin receptor-like kinase 7, ALK7, ACVR1C, Activin receptor type IC, ALK-7, Activin receptor type-1C, ACTR-IC
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:39809772
The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits., PMID:39137861
Activin E upregulates uncoupling protein 1 and fibroblast growth factor 21 in brown adipocytes., PMID:38972346
Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice., PMID:38714691
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:38633783
Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice., PMID:38307384
Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy., PMID:38235319
Circular RNA ZNF800 (hsa_circ_0082096) regulates cancer stem cell properties and tumor growth in colorectal cancer., PMID:37950151
The effect of ACVR1B/TGFBR1/ACVR1C signaling inhibition on oocyte and granulosa cell development during in vitro growth culture., PMID:37722883
Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice., PMID:37523551
Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells., PMID:36658621
Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders., PMID:36626233
Regulation of Nodal signaling propagation by receptor interactions and positive feedback., PMID:36149406
Integrated longitudinal analysis of adult grade 4 diffuse gliomas with long-term relapse interval revealed upregulation of TGF-β signaling in recurrent tumors., PMID:36124685
Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus., PMID:35927440
A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine/chemokine activity in OVA-induced asthmatic mice., PMID:35905568
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity., PMID:35896531
The orphan ligand, activin C, signals through activin receptor-like kinase 7., PMID:35736809
Hypoxia induced-disruption of lncRNA TUG1/PRC2 interaction impairs human trophoblast invasion through epigenetically activating Nodal/ALK7 signalling., PMID:35729773
Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats., PMID:35666032
Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution., PMID:34875679
Comparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells., PMID:34654356
Epstein-Barr virus microRNA BART10-3p promotes dedifferentiation and proliferation of nasopharyngeal carcinoma by targeting ALK7., PMID:34424090
Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7., PMID:34245608
Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7., PMID:34173336
Abnormal Expression and Prognostic Significance of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma., PMID:34036102
UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes., PMID:33499275
Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration., PMID:33228793
Mapping a Circular RNA-microRNA-mRNA-Signaling Regulatory Axis That Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells., PMID:33114016
ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression., PMID:32641645
ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARγ Expression., PMID:32467530
Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7., PMID:32366358
The Transcriptome of Pig Spermatozoa, and Its Role in Fertility., PMID:32106598
Differential expression of BMP/SMAD signaling and ovarian-associated genes in the granulosa cells of FecB introgressed GMM sheep., PMID:31957496
A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis., PMID:31704767
Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells., PMID:31608496
Molecular characterization and computational structure prediction of activin receptor type IIB in aseel and broiler chicken., PMID:31491670
A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling., PMID:31489365
Downregulation of Nodal inhibits metastatic progression in retinoblastoma., PMID:31451106
ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis., PMID:31063757
Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival., PMID:30409165
ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma., PMID:30401983
DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes., PMID:30389748
MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia., PMID:30367833
ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation., PMID:30012586
Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages., PMID:29945891
Gene expression changes in the retina after systemic administration of aldosterone., PMID:29713904
Endothelial cells enhance adipose mesenchymal stromal cell-mediated matrix contraction via ALK receptors and reduced follistatin: Potential role of endothelial cells in skin fibrosis., PMID:29345319
Learning induces the translin/trax RNase complex to express activin receptors for persistent memory., PMID:28927503
Overexpression of Activin Receptor-like Kinase 7 in Breast Cancer Cells Is Associated with Decreased Cell Growth and Adhesion., PMID:28668833
For research use only. Not for human or drug use.
