Catalog No.
YHJ24501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr631-Trp885
Predicted molecular weight
31.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NEB9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PtdIns-3-kinase type 3, Phosphatidylinositol 3-kinase p100 subunit, hVps34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, PI3-kinase type 3, VPS34, PI3K type 3, PIK3C3
Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy., PMID:40395527
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation., PMID:40378153
NSP6 regulates calcium overload-induced autophagic cell death and is regulated by KLHL22-mediated ubiquitination., PMID:40373961
A depression-associated protein FKBP5 functions in autophagy initiation through scaffolding the VPS34 complex., PMID:40175715
NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex., PMID:40013119
Subareolar sclerosing ductal hyperplasia shows PI3K pathway alterations., PMID:39888091
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease., PMID:39821606
Survival strategies of cancer cells: the role of macropinocytosis in nutrient acquisition, metabolic reprogramming, and therapeutic targeting., PMID:39817564
DYSREGULATION OF AUTOPHAGY IN PERIPHERAL BLOOD LEUCOCYTES IS A FACTOR IN THE DEVELOPMENT OF INFLAMMAGING IN IMMUNOCOMPROMISED PERSONS ON THE EXAMPLE OF THE SERVICEMEN OF THE DEFENSE FORCES OF UKRAINE AND CLEAN-UP WORKERS OF THE CHORNOBYL ACCIDENT., PMID:39724626
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development., PMID:39664390
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy., PMID:39641621
Synthetic rescue of Xeroderma Pigmentosum C phenotype via PIK3C3 downregulation., PMID:39562566
Bioinformatics analysis and identification of underlying biomarkers potentially linking allergic rhinitis and autophagy., PMID:39528529
Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis., PMID:39472682
A pro-oxidant suppresses unrelated diseases., PMID:39446962
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function., PMID:39446948
Expression, Characteristics, and Clinical Target Prediction of PIK3C3/ vps34 in Gastric Cancer., PMID:39354769
Pik3c3 expression profiling in the mouse kidney and its role in proximal tubule cell physiology., PMID:39250817
Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3/PUMA pathway., PMID:39245438
PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation., PMID:39240940
Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways., PMID:39177530
Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection., PMID:39173055
Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis., PMID:39117783
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases., PMID:39113560
Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model., PMID:39051473
FOXO-regulated DEAF1 controls muscle regeneration through autophagy., PMID:38963021
Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34., PMID:38872753
ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration., PMID:38838859
[Research progress in the regulation of autophagy and mitochondrial homeostasis by AMPK signaling channels]., PMID:38813640
VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy., PMID:38762759
In-silico Codon Context and Synonymous Usage Analysis of Genes for Molecular Mechanisms Inducing Autophagy and Apoptosis with Reference to Neurodegenerative Disorders., PMID:38728191
USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy., PMID:38705724
Nano implant surface triggers autophagy through membrane curvature distortion to regulate the osteogenic differentiation., PMID:38657629
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients., PMID:38609772
Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence., PMID:38544346
Unveiling potential drug targets for hyperparathyroidism through genetic insights via Mendelian randomization and colocalization analyses., PMID:38499600
Integrated bioinformatics analysis identifies autophagy-associated genes as candidate biomarkers and reveals the immune infiltration landscape in psoriasis., PMID:38439147
Protective effect of exosomes derived from bone marrow mesenchymal stem cells on hypoxia reperfusion injury of cardiomyocytes., PMID:38430039
PtdIns4P is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion., PMID:38411137
Enhancement of LC3-associated efferocytosis for the alleviation of intestinal inflammation., PMID:38311819
Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control., PMID:38253602
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy., PMID:38134519
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway., PMID:38060409
Communication between small cytosolic dsDNA and autophagy inhibits CGAS (cyclic GMP-AMP synthase) activation., PMID:38013411
ULK1 seen at the single-molecule level during autophagy initiation., PMID:37992308
The biological function of cytoplasm-translocated ENDOG (endonuclease G)., PMID:37889084
Isoforskolin modulates AQP4-SPP1-PIK3C3 related pathway for chronic obstructive pulmonary disease via cAMP signaling., PMID:37817209
CD44 connects autophagy decline and ageing in the vascular endothelium., PMID:37684253
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression., PMID:37644025
Lactate is a bridge linking glycolysis and autophagy through lactylation., PMID:37565742
For research use only. Not for human or drug use.
