Catalog No.
YHJ24101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly118-Glu282
Predicted molecular weight
20.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NCW5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AIBP, APOA1BP, Apolipoprotein A-I-binding protein, NAD(P)HX epimerase, YjeF N-terminal domain-containing protein 1, YJEFN1, YjeF_N1, NAXE, NAD(P)H-hydrate epimerase, AI-BP
Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells., PMID:39789421
Biallelic GGGCC repeat expansion leading to NAXE-related mitochondrial encephalopathy., PMID:39455596
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease., PMID:39342323
Identification and Validation of Nicotinamide Metabolism-Related Gene Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma., PMID:38827823
Progressive encephalopathy after routine 4-month immunizations in a patient with NAXD genetic variant., PMID:38214124
Apolipoprotein A-I Binding Protein Inhibits the Formation of Infantile Hemangioma through Cholesterol-Regulated Hypoxia-Inducible Factor 1α Activation., PMID:37832842
Severe NAD(P)HX Dehydratase (NAXD) Neurometabolic Syndrome May Present in Adulthood after Mild Head Trauma., PMID:36834994
AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons., PMID:36719418
Systems and strategies for plant protein expression., PMID:36710015
AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration., PMID:36429071
Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease., PMID:36332927
Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization., PMID:36318195
Identification of a novel homozygous mutation in NAXE gene associated with early-onset progressive encephalopathy by whole-exome sequencing: in silico protein structure characterization, molecular docking, and dynamic simulation., PMID:35819538
Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization., PMID:35525979
NAXE gene mutation-related progressive encephalopathy: A case report and literature review., PMID:34678889
NAD(P)HX epimerase downregulation promotes tumor progression through ROS/HIF-1α signaling in hepatocellular carcinoma., PMID:33932069
Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice., PMID:33793635
Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages., PMID:33356389
AIBP, Angiogenesis, Hematopoiesis, and Atherogenesis., PMID:33230630
Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein)., PMID:32787522
Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice., PMID:32678293
The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients., PMID:32199697
Genetic heterogeneity in Leigh syndrome: Highlighting treatable and novel genetic causes., PMID:32020600
Early-onset progressive encephalopathy associated with NAXE gene variants: a case report of a Turkish child., PMID:31758406
Novel NAXE variants as a cause for neurometabolic disorder: implications for treatment., PMID:31745726
AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux., PMID:31101050
AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation., PMID:30135304
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells., PMID:30098110
[Clinical and genetic features of early-onset progressive encephalopathy associated with NAXE gene mutations]., PMID:30022751
Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function., PMID:29654173
AIBP protects against metabolic abnormalities and atherosclerosis., PMID:29559522
AIBP, NAXE, and Angiogenesis: What's in a Name?, PMID:28546345
AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling., PMID:28325782
NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood., PMID:27616477
Homozygous mutation in the APOA1BP is associated with a lethal infantile leukoencephalopathy., PMID:27122014
AIBP: A Novel Molecule at the Interface of Cholesterol Transport, Angiogenesis, and Atherosclerosis., PMID:26634023
Occurrence and subcellular distribution of the NADPHX repair system in mammals., PMID:24611804
Identification of unknown protein function using metabolite cocktail screening., PMID:22940582
Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation., PMID:18202122
ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis., PMID:17533573
Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I., PMID:11991719
Estradiol stimulates apolipoprotein A-I- but not A-II-containing particle synthesis and secretion by stimulating mRNA transcription rate in Hep G2 cells., PMID:9633943
Studies on the proteins involved in the interaction of high-density lipoprotein with isolated human small intestine epithelial cells., PMID:1607020
Apolipoprotein A-I-binding protein from human term placenta. Purification and partial characterization., PMID:3106088
For research use only. Not for human or drug use.
