Catalog No.
YHJ23901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu113-Ser356
Predicted molecular weight
30.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NBK3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Formylglycine-generating enzyme, FGE, SUMF1, Sulfatase-modifying factor 1, C-alpha-formylglycine-generating enzyme 1
Novel drug targets for delirium based on genetic causality., PMID:40023257
Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma., PMID:39915362
Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series., PMID:39789203
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study., PMID:39734218
Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model., PMID:39448727
Production of active human iduronate-2-sulfatase (IDS) enzyme in Nicotiana benthamiana., PMID:39367006
TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44., PMID:39348940
Boolean Modeling of Biological Network Applied to Protein-Protein Interaction Network of Autism Patients., PMID:39194544
Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency., PMID:39169621
Non-syndromic retinal dystrophy associated with biallelic variation of SUMF1 and reduced leukocyte sulfatase activity., PMID:38863195
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease., PMID:38467937
SUMF1 overexpression promotes tumorous cell growth and migration and is correlated with the immune status of patients with glioma., PMID:38460946
A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency., PMID:38161139
Identification of 6 cuproptosis-related genes for active ulcerative colitis with both diagnostic and therapeutic values., PMID:37904461
Association between SUMF1 polymorphisms and COVID-19 severity., PMID:37344788
Late infantile form of multiple sulfatase deficiency with a novel missense variant in the SUMF1 gene: case report and review., PMID:36959582
Identification of a copper metabolism-related gene signature for predicting prognosis and immune response in glioma., PMID:36856182
Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency., PMID:36789546
Genetic analysis of a novel SUMF1 variation associated with a late infantile form of multiple sulfatase deficiency., PMID:36441600
New mouse models with hypomorphic SUMF1 variants mimic attenuated forms of multiple sulfatase deficiency., PMID:36433920
miRNA-mediated alteration of sulfatase modifying factor 1 expression using self-assembled branched DNA nanostructures., PMID:35423539
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease., PMID:34112972
Evaluation of HIV-1 derived lentiviral vectors as transductors of Mucopolysaccharidosis type IV a fibroblasts., PMID:33636292
Genome-wide identification and analysis of sulfatase and sulfatase modifying factor genes in Bemisia tabaci (Hemiptera: Aleyrodidae)., PMID:33399267
Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives., PMID:33335837
Evaluation of Arylsulfatase D (ARSD) and long noncoding RNA ARSD-AS1 gene expression in breast cancer patients and their association with oncogenic transcription factors., PMID:33099917
Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories., PMID:33051690
Natural history of multiple sulfatase deficiency: Retrospective phenotyping and functional variant analysis to characterize an ultra-rare disease., PMID:32749716
A systematic review and meta-analysis of published cases reveals the natural disease history in multiple sulfatase deficiency., PMID:32621519
Multiple Sulfatase Deficiency: A Disease Comprising Mucopolysaccharidosis, Sphingolipidosis, and More Caused by a Defect in Posttranslational Modification., PMID:32414121
A homozygous missense variant of SUMF1 in the Bedouin population extends the clinical spectrum in ultrarare neonatal multiple sulfatase deficiency., PMID:32048457
Inhibition of endogenous miR-23a/miR-377 in CHO cells enhances difficult-to-express recombinant lysosomal sulfatase activity., PMID:31990124
Severe neonatal multiple sulfatase deficiency presenting with hydrops fetalis in a preterm birth patient., PMID:31497481
Site-Specific Bioconjugation Using SMARTag® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates., PMID:31332752
Measurement of recombinant human arylsulfatase A and leukocyte sulfatase activities by analytical isotachophoresis., PMID:31195190
One-step Preparation of a VHH-based Immunoadsorbent for the Extracorporeal Removal of β2-microglobulin., PMID:31167508
Site-Specific Labeling of Proteins Using the Formylglycine-Generating Enzyme (FGE)., PMID:31161504
An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA., PMID:31020862
Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival., PMID:30760814
Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease., PMID:30760748
Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation., PMID:30598261
Multiple Sulfatase Deficiency: A Case Series With a Novel Mutation., PMID:30124108
Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase., PMID:29972788
The report of two cases with multiple sulfatase deficiency resulting from a rare similar gene mutation., PMID:29479672
Complex care of individuals with multiple sulfatase deficiency: Clinical cases and consensus statement., PMID:29397290
Structural distortions due to missense mutations in human formylglycine-generating enzyme leading to multiple sulfatase deficiency., PMID:29048999
Cell lines from diamondback moth exhibiting differential susceptibility to baculovirus infection and expressing midgut genes., PMID:28857510
Structure and expression of sulfatase and sulfatase modifying factor genes in the diamondback moth, Plutella xylostella., PMID:28569426
Expanding the genetic cause of multiple sulfatase deficiency: A novel SUMF1 variant in a patient displaying a severe late infantile form of the disease., PMID:28566233
Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease., PMID:28464818
For research use only. Not for human or drug use.
