Catalog No.
YHJ23601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu263
Predicted molecular weight
33.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NB16
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mixed lineage kinase domain-like protein, MLKL, hMLKL
Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis., PMID:40513868
Distinct Types of Regulated Cell Death in Melanoma., PMID:40497999
CYPD limits HR+ mammary carcinogenesis in mice., PMID:40494873
From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases., PMID:40493155
Receptor interacting protein kinase 1 activation and triggering mesangial cells necroptosis in MRL/lpr mice model of lupus nephritis., PMID:40492666
MLKL‒OPTN axis regulates herpesvirus-induced neurological sequelae., PMID:40490945
Keratinocyte necroptosis promotes the progression of radiation-induced oral mucositis., PMID:40483488
Anti-inflammatory mechanism of the MLKL inhibitor necrosulfonamide in LPS- or poly(I:C)-induced neuroinflammation and necroptosis., PMID:40473224
Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney., PMID:40460938
Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells., PMID:40458801
Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species., PMID:40437958
CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation., PMID:40436345
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis., PMID:40430799
Hydrogen Sulfide (H2S) Mitigates Sepsis-Induced Adrenal Dysfunction via Inhibition of TNFα-Mediated Necroptosis., PMID:40430756
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics., PMID:40425585
CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis., PMID:40425550
A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis., PMID:40424123
Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis., PMID:40418410
Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction., PMID:40412245
Advances in MLKL-targeted inhibitors and PROTACs for necroptosis therapeutics., PMID:40409166
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation., PMID:40408995
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway., PMID:40407231
Investigating the role of necroptosis in the immunological microenvironment of periodontitis., PMID:40402323
Discovery of quinazoline derivatives as RIPK3 inhibitors that switch cell death from necroptosis to apoptosis for psoriasis treatment., PMID:40398153
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe., PMID:40378591
Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease., PMID:40359032
Dusp14-Mediated Dephosphorylation of MLKL Protects Against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure., PMID:40357546
TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling., PMID:40350054
Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy., PMID:40345706
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure., PMID:40344700
Epigenetic Inactivation of RIPK3-Dependent Necroptosis Augments Cisplatin Chemoresistance in Human Osteosarcoma., PMID:40332549
Depletion of oxysterol-binding proteins by OSW-1 triggers RIP1/RIP3-independent necroptosis and sensitization to cancer immunotherapy., PMID:40329104
Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro., PMID:40328155
Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis., PMID:40327971
[Disulfiram alleviates cardiac hypertrophic injury by inhibiting TAK1-mediated PANoptosis]., PMID:40326066
Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy., PMID:40319089
Theaflavin suppresses necroptosis by attenuating RIPK1-RIPK3-MLKL signaling and mitigates cisplatin-induced kidney injury in mice., PMID:40318271
Nano-selenium alleviates tetrabromobisphenol A induced PANoptosis in carp gill tissue by inhibiting TLR4/MyD88/NF-κB pathway., PMID:40311953
The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis., PMID:40311590
Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins., PMID:40307003
Modeling Necroptotic and Pyroptotic Signaling in Saccharomyces cerevisiae., PMID:40305268
S-acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function., PMID:40304073
RIPK1/RIPK3/MLKL Necrosome Contributes to the Sepsis-Induced Cardiorenal Necroptotic Inflammatory Injury and Mortality., PMID:40296630
Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia., PMID:40287728
Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection., PMID:40281523
ZBP1 senses splicing aberration through Z-RNA to promote cell death., PMID:40267920
Neuregulin-1 prevents death from a normally lethal respiratory viral infection., PMID:40267147
Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice., PMID:40264785
MLKL is involved in the regulation of skin wound healing and interplay between macrophages and myofibroblasts in mice., PMID:40253554
The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure., PMID:40249973
For research use only. Not for human or drug use.
