Catalog No.
YHJ23201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu302
Predicted molecular weight
35.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N9F0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-acetyltransferase 8-like protein, NAA synthetase, Camello-like protein 3, N-acetylaspartate synthetase, NAT8L, CML3
[Modulation of Cognitive and Psychiatric Functions by Psychostimulant-responsive Molecules]., PMID:40024726
Hippocampus-specific knockdown of Shati/Nat8l impairs cognitive function and electrophysiological response in mice., PMID:39116682
The Role of GABA in the Dorsal Striatum-Raphe Nucleus Circuit Regulating Stress Vulnerability in Male Mice with High Levels of Shati/Nat8l., PMID:37813564
DNA methylation status of SHATI/NAT8L promoter in the blood of cigarette smokers., PMID:37668111
Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice., PMID:37610133
NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis., PMID:36882060
Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation., PMID:36580805
LncRNA GAS5 promotes spermidine‑induced autophagy through the miRNA‑31‑5p/NAT8L axis in pulmonary artery endothelial cells of patients with CTEPH., PMID:35920180
Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer's Disease Model Mice., PMID:35759136
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice., PMID:35428956
Downregulation of CHCHD2 may Contribute to Parkinson's Disease by Reducing Expression of NFE2L2 and RQCD1., PMID:35388756
The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain., PMID:34573036
High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease., PMID:34477360
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation., PMID:34099867
Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis - Part 2: Acetate and ACSS2 in Health and Disease., PMID:33304273
Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases., PMID:33281616
Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells., PMID:33198375
Impairment of cognitive function induced by Shati/Nat8l overexpression in the prefrontal cortex of mice., PMID:32998043
CD73 promotes colitis-associated tumorigenesis in mice., PMID:32724362
Structure of the Brain N-Acetylaspartate Biosynthetic Enzyme NAT8L Revealed by Computer Modeling., PMID:32639720
Investigating DNA Methylation of SHATI/NAT8L Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder., PMID:32612069
[Novel molecules-related drug dependence in mice]., PMID:32378630
Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for TNBC and gene set prediction combination., PMID:32317088
Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus., PMID:32275776
A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood., PMID:31924153
Vulnerability to depressive behavior induced by overexpression of striatal Shati/Nat8l via the serotonergic neuronal pathway in mice., PMID:31520691
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation., PMID:31376479
Regulatory system of mGluR group II in the nucleus accumbens for methamphetamine-induced dopamine increase by the medial prefrontal cortex., PMID:31283871
Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice., PMID:30950164
Pathophysiology and Treatment of Canavan Disease., PMID:30535831
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model., PMID:29456021
Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development., PMID:29203794
Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate., PMID:29203337
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy., PMID:29116375
Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice., PMID:29020418
Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism., PMID:28319198
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition., PMID:27709268
Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype., PMID:27348532
Role of Increased n-acetylaspartate Levels in Cancer., PMID:26819345
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells., PMID:26565952
Purification and characterization of aspartate N-acetyltransferase: A critical enzyme in brain metabolism., PMID:26550943
Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker., PMID:26511490
Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate., PMID:26361739
Induction of neuronal axon outgrowth by Shati/Nat8l by energy metabolism in mice cultured neurons., PMID:26164607
Transcriptional regulation of N-acetylaspartate metabolism in the 5xFAD model of Alzheimer's disease: evidence for neuron-glia communication during energetic crisis., PMID:25766789
Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice., PMID:24559655
Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence., PMID:24246274
NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes., PMID:24155240
SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization., PMID:24105954
For research use only. Not for human or drug use.
