Catalog No.
YHJ22801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys133-Ser301
Predicted molecular weight
20.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N6Q3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD177, NB1 GP, HNA-2a, Human neutrophil alloantigen 2a, NB1, PRV-1, CD177 antigen, Polycythemia rubra vera protein 1, NB1 glycoprotein, PRV1
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury., PMID:40398393
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622
Identification of Hub Genes and Key Pathways Associated with Sepsis Progression Using Weighted Gene Co-Expression Network Analysis and Machine Learning., PMID:40362669
Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure., PMID:40285622
St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury., PMID:40244680
Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock., PMID:40140612
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription., PMID:40108025
Aberrant expansion of CD177+ neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps., PMID:40088615
A two-transcript classifier model for assessing disease activity in patients with ulcerative colitis: A discovery and validation study., PMID:40069026
Integrated single-cell and spatial transcriptomic profiling reveals that CD177+ Tregs enhance immunosuppression through apoptosis and resistance to immunotherapy in hepatocellular carcinoma., PMID:40055567
CD177+ neutrophils exacerbate septic lung injury via the NETs/AIM2 pathway: An experimental and bioinformatics study., PMID:40007380
Circulating RNA Markers Associated with Adenoma-Carcinoma Sequence in Colorectal Cancer., PMID:40003985
CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections., PMID:39915095
Pregnancy is associated with a simultaneous but independent increase in circulating CD177pos and immature low-density granulocytes., PMID:39698836
Meningeal neutrophil immune signaling influences behavioral adaptation following threat., PMID:39561768
Unveiling shared diagnostic biomarkers and molecular mechanisms between T2DM and sepsis: Insights from bioinformatics to experimental assays., PMID:39382024
The tumor cell killing capacity of head and neck cancer patient-derived neutrophils depends on tumor stage, gender and the antibody isotype., PMID:39306937
Immune microenvironmental heterogeneity according to tumor DNA methylation phenotypes in microsatellite instability-high colorectal cancers., PMID:39235590
Dual role of CD177 + neutrophils in inflammatory bowel disease: a review., PMID:39223577
Proteomic analysis of peripheral blood mononuclear cells from OSCC patients reveals potential immune checkpoints to enable personalized treatment., PMID:39177064
CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function., PMID:39131159
Construction of a panoramic mRNA map of adult noncystic fibrosis bronchiectasis and a preliminary study of the underlying molecular mechanisms., PMID:39127654
Immune-enhancing neutrophils reprogrammed by subclinical low-dose endotoxin in cancer treatment., PMID:39009886
Dupilumab Therapy Modulates Circulating Inflammatory Mediators in Patients with Prurigo Nodularis., PMID:38947360
Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns., PMID:38919617
CD177 on neutrophils engages stress-related behavioral changes in male mice., PMID:38871062
Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction., PMID:38715615
Predictive Value of a Diagnostic Five-Gene Biomarker for Pediatric Sepsis., PMID:38595339
S100A9 exacerbates sepsis-induced acute lung injury via the IL17-NFκB-caspase-3 signaling pathway., PMID:38588614
Side scatter ratio of the CD105-positive and CD105-negative red blood cell fractions is useful for the detection of low-grade myelodysplastic neoplasms by flow cytometry., PMID:38581145
Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma., PMID:38516269
The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype., PMID:38474126
Fc receptors are key discriminatory markers of granulocytes subsets in people living with HIV-1., PMID:38384451
The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination., PMID:38332914
Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing., PMID:38332910
Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis., PMID:38290402
The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury., PMID:38226808
Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies., PMID:38213873
OMIP-100: A flow cytometry panel to investigate human neutrophil subsets., PMID:38179854
Association between increased CD177 + neutrophils and chronic activation in people living with HIV., PMID:38013464
Single-Cell Meta-Analysis of Neutrophil Activation in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children Reveals Potential Shared Immunological Drivers., PMID:37905415
Transcriptomic comparison of bone marrow CD34 + cells and peripheral blood neutrophils from ET patients with JAK2 or CALR mutations., PMID:37550636
Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets., PMID:37495829
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection., PMID:37434783
Identification of the shared gene signatures and molecular pathways in systemic lupus erythematosus and diffuse large B-cell lymphoma., PMID:37392050
Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study., PMID:37359526
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity., PMID:37302069
Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis., PMID:37201587
Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning., PMID:37115484
CD177 Inhibits Neutrophil Extracellular Trap Formation and Protects against Acute Pancreatitis in Mice., PMID:37048616
For research use only. Not for human or drug use.
