Catalog No.
YHJ22701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln267-Gly565
Predicted molecular weight
34.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N6P7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRF2-9, IL-22RA1, IL22RA1, ZcytoR11, IL-22R-alpha-1, IL-22 receptor subunit alpha-1, Cytokine receptor class-II member 9, Interleukin-22 receptor subunit alpha-1, Cytokine receptor family 2 member 9, IL22R
Causal relationship between circulating inflammatory proteins and atherosclerosis: a bidirectional Mendelian randomization study and meta-analysis., PMID:40339743
Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin., PMID:40236066
Combination of inflammatory proteins in serum can be used to diagnose papillary thyroid carcinoma with lymph node metastasis., PMID:39812761
Interleukin-22 promotes endometrial carcinoma cell proliferation and cycle progression via ERK1/2 and p38 activation., PMID:39690293
Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3., PMID:39675006
Harnessing IL-22 for metabolic health: promise and pitfalls., PMID:39578121
Exploring the relationship between the interleukin family and lung adenocarcinoma through Mendelian randomization and RNA sequencing analysis., PMID:39264458
[Inflammatory factors and prostate cancer: Two-sample Mendelian randomization analysis]., PMID:39212392
IL-22/IL-22RA1 Promotes Human Tenon's Capsule Fibroblasts Proliferation and Regulates Fibrosis Through STAT3 Signaling Pathway., PMID:39046932
Hepatic IL22RA1 deficiency promotes hepatic steatosis by modulating oxysterol in the liver., PMID:38985984
Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs., PMID:38949991
Genetically predicted associations between circulating cytokines and autoimmune diseases: a bidirectional two-sample Mendelian randomization., PMID:38860028
Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis., PMID:38811550
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis., PMID:38811532
IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation., PMID:38733584
IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury., PMID:38101567
Evolutionarily conserved IL-22 participates in gut mucosal barrier through its receptors IL-22BP, IL-10R2 and IL-22RA1 during bacterial infection in teleost., PMID:38081403
IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury., PMID:38054920
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells., PMID:37695525
Goose Hepatic IGFBP2 Is Regulated by Nutritional Status and Participates in Energy Metabolism Mainly through the Cytokine-Cytokine Receptor Pathway., PMID:37508113
IL-22 promotes acute kidney injury through activation of the DNA damage response and cell death in proximal tubule cells., PMID:37333314
The TH 22-mediated IL-22 deficiency associated with premature ovarian insufficiency., PMID:36752193
A Critical Role of the IL-22-IL-22 Binding Protein Axis in Hepatocellular Carcinoma., PMID:36551508
Germline variants associated with toxicity to immune checkpoint blockade., PMID:36526723
IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis., PMID:35874683
Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C., PMID:35838587
Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1., PMID:35726847
Identification of a Prognostic Signature Composed of GPI, IL22RA1, CCT6A and SPOCK1 for Lung Adenocarcinoma Based on Bioinformatic Analysis of lncRNA-Mediated ceRNA Network and Sample Validation., PMID:35433415
IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor., PMID:35304419
Mechanism underlying the effect of Liujunzi decoction on advanced-stage non-small cell lung cancer in patients after first-line chemotherapy., PMID:35294130
Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases., PMID:35054813
A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum., PMID:34917080
Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model., PMID:34836520
Interleukin-22 Deficiency Contributes to Dextran Sulfate Sodium-Induced Inflammation in Japanese Medaka, Oryzias latipes., PMID:34759916
Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation., PMID:34557075
Clinical Significance and Immunologic Landscape of a Five-IL(R)-Based Signature in Lung Adenocarcinoma., PMID:34497605
Protective function of interleukin-22 in pulmonary fibrosis., PMID:34459137
High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer., PMID:34134925
Specific bioactivity of IL-22 in intestinal cells as revealed by the expression of IL-22RA1 in Mandarin fish, Siniperca chuatsi., PMID:33878363
Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization., PMID:33771530
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias., PMID:33753942
Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis., PMID:33570127
Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury., PMID:33502147
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity., PMID:33060802
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps., PMID:32935490
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis., PMID:32503875
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer., PMID:32430479
Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infection., PMID:32213713
Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis., PMID:31879195
Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet., PMID:31817755
For research use only. Not for human or drug use.
