Catalog No.
YHJ21401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn455-Arg675
Predicted molecular weight
28.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N3R9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PALS1, MAGUK p55 subfamily member 5, MPP5
Host and bacterial urine proteomics might predict treatment outcomes for immunotherapy in advanced non-small cell lung cancer patients., PMID:40297587
The Cell Polarity Protein MPP5/PALS1 Controls the Subcellular Localization of the Oncogenes YAP and TAZ in Liver Cancer., PMID:39859373
PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells., PMID:38265145
Circulating and Endometrial Profiles of miR-145, miR-155-5p, miR-224, MPP-5, and PECAM-1 Expression in Patients with Repeated Implantation Failure: A Case Control Study., PMID:37434460
Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice., PMID:37080459
A case of a childhood onset developmental encephalopathy with a novel de novo truncating variant in the Membrane Protein Palmitoylated 5 (MPP5) gene., PMID:36710240
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion., PMID:36494580
Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., PMID:35283834
Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice., PMID:35037164
Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance., PMID:34531452
Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells., PMID:34228789
Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain., PMID:34117354
Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1., PMID:34103506
Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6., PMID:33941200
De novo variants in MPP5 cause global developmental delay and behavioral changes., PMID:33073849
Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis., PMID:32891874
Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein., PMID:32822073
Functional Architecture of Motion Direction in the Mouse Superior Colliculus., PMID:32649907
SARS-CoV2 envelope protein: non-synonymous mutations and its consequences., PMID:32640274
KLF4 Coordinates Corneal Epithelial Apical-Basal Polarity and Plane of Cell Division and Is Downregulated in Ocular Surface Squamous Neoplasia., PMID:32396634
C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density., PMID:32366143
Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease., PMID:30130524
Evaluation of CPP-ACP and Fluoride on Inhibition of Human Enamel demineralisation: Cross-sectional Hardness and MicroCT Studies., PMID:29319064
Asymmetric distribution of CRUMBS polarity complex proteins from compacted 8-cell to blastocyst stage during mouse preimplantation development., PMID:29155075
Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing., PMID:28709640
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity., PMID:28618099
Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock., PMID:28361006
Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation., PMID:28154200
The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin., PMID:27521426
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation., PMID:27466317
Par3A is dispensable for the function of the glomerular filtration barrier of the kidney., PMID:27122542
The C-terminal domain controls the mobility of Crumbs 3 isoforms., PMID:26975581
Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon., PMID:26802325
The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state., PMID:26657772
The Polarity Protein Pals1 Regulates Radial Sorting of Axons., PMID:26203142
Effect of different application frequencies of CPP-ACP and fluoride dentifrice on demineralized enamel: a laboratory study., PMID:25831605
Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove., PMID:25760605
Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye., PMID:25636444
Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer., PMID:24488012
Crumbs3 is essential for proper epithelial development and viability., PMID:24164893
Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells., PMID:24085853
MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells., PMID:23893895
The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex., PMID:23880463
Function and cancer genomics of FAT family genes (review)., PMID:23076869
Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability., PMID:22791898
Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis., PMID:22398208
Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode., PMID:22337881
PALS1 is essential for retinal pigment epithelium structure and neural retina stratification., PMID:22114289
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions., PMID:21481793
Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation., PMID:21479189
For research use only. Not for human or drug use.
