Catalog No.
YHJ21301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln25-Ile435
Predicted molecular weight
47.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N3J6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nectin-like protein 3, Synaptic cell adhesion molecule 2, IGSF4D, CADM2, NECL-3, Cell adhesion molecule 2, NECL3, SynCAM 2, IgSF4D, Immunoglobulin superfamily member 4D
Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering., PMID:40192292
Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation., PMID:40064225
L1CAM+ extracellular vesicles derived from the serum of adolescents with major depressive disorder induce depression-like phenotypes in adolescent mice., PMID:39842672
Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease., PMID:39009667
Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis., PMID:38990915
CADM2 participates in endometriosis development by influencing the epithelial-mesenchymal transition., PMID:38767769
Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis., PMID:38565336
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2., PMID:38369215
hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis., PMID:38126999
Genetic correlation for alcohol consumption between Europeans and East Asians., PMID:37904118
Identification of autophagy and angiogenesis modulators in colorectal cancer based on bioinformatics analysis., PMID:37791824
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions., PMID:37316926
Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma., PMID:37228062
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice., PMID:37173343
Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein., PMID:37166307
Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure., PMID:36869404
Genomic patterns linked to gray matter alterations underlying working memory deficits in adults and adolescents with attention-deficit/hyperactivity disorder., PMID:36774336
Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma., PMID:36768928
[RNA Virus Pathogenicity, Evolution, and Intrapopulation Interaction]., PMID:39343534
Long noncoding RNA WT1-AS regulates trophoblast proliferation, migration, and invasion via the microRNA-186-5p/CADM2 axis., PMID:36561840
Transcriptome-wide association study by different approaches reveals candidate causal genes for cannabis use disorder., PMID:36379386
KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design., PMID:36150388
Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers., PMID:36045381
Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis., PMID:35800456
Genome-Wide Placental Gene Methylations in Gestational Diabetes Mellitus, Fetal Growth and Metabolic Health Biomarkers in Cord Blood., PMID:35721735
MiR-17-5p Targets and Downregulates CADM2, Activating the Malignant Phenotypes of Colon Cancer Cells., PMID:35696058
Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2., PMID:35279660
Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis., PMID:35064931
Genome-Wide Profiling Reveals HPV Integration Pattern and Activated Carcinogenic Pathways in Penile Squamous Cell Carcinoma., PMID:34885212
Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin., PMID:34788082
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders., PMID:34741163
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis., PMID:33910952
A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement., PMID:33889941
FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis., PMID:33882368
Longitudinal genetic studies of cognitive characteristics., PMID:33659785
Associations between the CADM2 gene, substance use, risky sexual behavior, and self-control: A phenome-wide association study., PMID:33604983
The UFSP2/UFMylation Pathway Is Involved in Silica-Induced Pulmonary Injury., PMID:33600261
Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes., PMID:33424774
Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons., PMID:33397712
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents., PMID:33346031
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder., PMID:33168801
Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay., PMID:33119910
Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B., PMID:33096475
ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma., PMID:32892630
[Effects of microRNA-182-5p on cell proliferation and invasion of esophageal squamous cell carcinoma and related molecular mechanisms]., PMID:32867454
Copy number variation of CADM2 gene revealed its association with growth traits across Chinese Capra hircus (goat) populations., PMID:32126252
Functional characteristics of autophagy in pancreatic cancer induced by glutamate metabolism in pancreatic stellate cells., PMID:31856624
Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse., PMID:31733789
Coordinated internodal and paranodal adhesion controls accurate myelination by oligodendrocytes., PMID:31451613
Genetic variation in CADM2 as a link between psychological traits and obesity., PMID:31089183
For research use only. Not for human or drug use.
