Catalog No.
YHJ18901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe337-Arg649
Predicted molecular weight
62.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IWU5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Extracellular sulfatase Sulf-2, KIAA1247, SULF2, hSulf-2
Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan., PMID:40302034
Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP., PMID:40140347
Detection of Microsatellite Instability in Endometrial Carcinoma Using a Novel Homopolymer Assay., PMID:40033864
Oklahoma nitrone-007 is an effective anticancer therapeutic agent targeting inflammatory and immune metabolism pathways in endometrial cancer., PMID:39893009
Cell-penetrating anti-sense peptide nucleic acids targeting sulfatase 2 inhibit adipogenesis in human mesenchymal stem cells., PMID:39566353
Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis., PMID:39368561
Utility of an Untargeted Metabolomics Approach Using a 2D GC-GC-MS Platform to Distinguish Relapsing and Progressive Multiple Sclerosis., PMID:39330500
The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis., PMID:39141086
Manipulating host secreted protein gene expression: an indirect approach by HPV11/16 E6/E7 to suppress PBMC cytokine secretion., PMID:39095779
Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2., PMID:38825040
Aspartate β-Hydroxylase Is Upregulated in Head and Neck Squamous Cell Carcinoma and Regulates Invasiveness in Cancer Cell Models., PMID:38732216
The immune cells have complex causal regulation effects on cancers., PMID:38710118
Utility of an untargeted metabolomics approach using a 2D GC-GC-MS platform to distinguish relapsing and progressive multiple sclerosis., PMID:38370675
TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma., PMID:38332153
Integrating Machine Learning and Mendelian Randomization Determined a Functional Neurotrophin-Related Gene Signature in Patients with Lower-Grade Glioma., PMID:38261152
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2., PMID:38187586
Human extracellular sulfatases use a dual mechanism for regulation of growth factor interactions with heparan sulfate proteoglycans., PMID:38045270
The Cancer/Testis Antigen CT45A1 Promotes Transcription of Oncogenic Sulfatase-2 Gene in Breast Cancer Cells and Is Sensible Targets for Cancer Therapy., PMID:37095619
A 6-O-endosulfatase activity assay based on synthetic heparan sulfate oligomers., PMID:37052463
The prognostic value and immunological role of SULF2 in adrenocortical carcinoma., PMID:36852051
Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer., PMID:36195266
Sulf2 mediates the effects of TNF in RASFs., PMID:36167820
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts., PMID:36068294
Transcription level and phylogeny analyses of Chlamydomonas reinhardtii arylsulfatases., PMID:36018447
SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer., PMID:35472437
Context Dependent Sulf1/Sulf2 Functional Divergence in Endothelial Cell Activity., PMID:35409127
Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity., PMID:35294879
PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification., PMID:35259473
Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2., PMID:34808537
Modulation of cell signalling and sulfation in cardiovascular development and disease., PMID:34789772
Measuring Sulfatase Expression and Invasion in Glioblastoma., PMID:34626397
The Long Non-Coding RNA H19 Drives the Proliferation of Diffuse Intrinsic Pontine Glioma with H3K27 Mutation., PMID:34502082
PPARγ-Induced Global H3K27 Acetylation Maintains Osteo/Cementogenic Abilities of Periodontal Ligament Fibroblasts., PMID:34445348
Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches., PMID:34324645
The upregulation of miR-204-3p in LPS-induced acute lung injury aggravated pulmonary endothelial cells apoptosis via targeting sulfatase 2., PMID:34033710
The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro., PMID:33923753
Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer., PMID:33908819
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration., PMID:33811915
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination., PMID:33772011
Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis., PMID:33735525
Expression of the Extracellular Sulfatase SULF2 Affects Survival of Head and Neck Squamous Cell Carcinoma Patients., PMID:33585200
Detection of selection signatures for response to Aleutian mink disease virus infection in American mink., PMID:33536540
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension., PMID:33322916
Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates., PMID:33318190
Sulfatase 1 mediates IL-10-induced dimethylarginine dimethylaminohydrolase-1 expression and antiproliferative effects in vascular smooth muscle cells of spontaneously hypertensive rats., PMID:33128921
Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression., PMID:33076548
Identification of differentially expressed metastatic genes and their signatures to predict the overall survival of uveal melanoma patients by bioinformatics analysis., PMID:32685390
Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease., PMID:32683952
SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models., PMID:32413029
Quantile-dependent expressivity of postprandial lipemia., PMID:32101585
For research use only. Not for human or drug use.
