Catalog No.
YHJ17802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys2-Pro996
Predicted molecular weight
115.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86Z14
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Klotho beta-like protein, KLB, Beta-klotho, BetaKlotho, BKL
Promotion of obesity by fibroblast growth factor 21-oxytocin system dysfunction due to sugar-specific hyperphagia., PMID:40445899
TSG attenuated NAFLD and facilitated weight loss in HFD-fed mice via activating the RUNX1/FGF21 signaling axis., PMID:40307458
Discovery of potent and selective PROTACs for the protein kinase LZK for the treatment of head and neck cancer., PMID:40157536
Sex-dependent effects of FGF21 on HPA axis regulation and adrenal regeneration after Cushing syndrome in mice., PMID:40154841
Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials., PMID:39805302
Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells., PMID:39798471
Site-specific analysis and functional characterization of N-linked glycosylation for β-Klotho protein., PMID:39701265
FGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis., PMID:39637324
GLP-1 Receptor Agonists Alleviate Diabetic Kidney Injury via β-Klotho-Mediated Ferroptosis Inhibition., PMID:39630101
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas., PMID:39613843
Identification of Novel Proteins Mediating Causal Association Between Smoking and Essential Hypertension: A Mendelian Randomization Study., PMID:39604029
Prenatal Acoustic Signals Influence Nestling Heat Shock Protein Response to Heat and Heterophil-to-Lymphocyte Ratio in a Desert Bird., PMID:39596260
FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling., PMID:39571902
Treating metabolic dysfunction-associated steatohepatitis: The fat-trimming FGF21 approach., PMID:39546893
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury., PMID:39545953
Systematic identification of therapeutic targets for coronary artery calcification: an integrated transcriptomic and proteomic Mendelian randomization., PMID:39526184
A primer on the pleiotropic endocrine fibroblast growth factor FGF19/FGF15., PMID:39500656
β-Klotho as novel therapeutic target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A narrative review., PMID:39490050
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice., PMID:39463193
CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD., PMID:39427187
Characterization of FGF21 Sites of Production and Signaling in Mice., PMID:39253796
Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., PMID:39226764
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy., PMID:39213194
Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1., PMID:39209138
Biohybrid hydrogel inhibiting β-klotho/HDAC3 axis for hepatocellular carcinoma treatment., PMID:39098678
Development and validation of a predictive model based on β-Klotho for head and neck squamous cell carcinoma., PMID:39048709
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders., PMID:39033378
Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration., PMID:38995966
Exploring potential plasma drug targets for cholelithiasis through multiancestry Mendelian randomization., PMID:38976909
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank., PMID:38862028
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer., PMID:38843329
FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling., PMID:38798313
The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?, PMID:38795981
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells., PMID:38772712
Alzheimer's disease pathophysiology in the Retina., PMID:38759947
Serum β-klotho is a potential biomarker for the progression of hepatitis B virus-related liver diseases., PMID:38728647
Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction., PMID:38666537
Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis., PMID:38609395
Effects of foetal size, sex and developmental stage on adaptive transcriptional responses of skeletal muscle to intrauterine growth restriction in pigs., PMID:38605102
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders., PMID:38585811
Transcriptomic and proteomic profiles of fetal versus adult mesenchymal stromal cells and mesenchymal stromal cell-derived extracellular vesicles., PMID:38475970
Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow's milk allergy., PMID:38448113
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells., PMID:38418879
Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab., PMID:38343040
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people., PMID:38277453
Targeting the FGF19-FGFR4 pathway for cholestatic, metabolic, and cancerous diseases., PMID:38212977
Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls., PMID:38158702
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2., PMID:38141848
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing β-cell function and survival via FGF15/19., PMID:38117265
Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study., PMID:37978492
For research use only. Not for human or drug use.
