Catalog No.
YHJ16501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser448-Thr976
Predicted molecular weight
63.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86W56
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PARG, Poly(ADP-ribose) glycohydrolase
DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint., PMID:40472742
Liquid‒liquid phase separation and poly(ADP‒ribosyl)ation in the context of ultraviolet radiation-induced stress in mammalian cells., PMID:40376396
DNMT1 is required for efficient DSB repair and maintenance of replication fork stability, and its loss reverses resistance to PARP inhibitors in cancer cells., PMID:40234721
Family-wide analysis of human macrodomains reveals novel activities and identifies PARG as most efficient ADPr-RNA hydrolase., PMID:40102620
Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack., PMID:39964479
[Banxia Xiexin Decoction suppresses malignant phenotypes of colon cancer cells via PARG/PARP1/NF-κB signaling pathway]., PMID:39929630
Increasing cellular NAD+ protects hepatocytes against palmitate-induced lipotoxicity by preventing PARP-1 inhibition and the mTORC1-p300 pathway activation., PMID:39871470
RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining., PMID:39870799
Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload., PMID:39842602
Poly(ADP-ribose) polymerase FonPARP1-catalyzed PARylation of protein disulfide isomerase FonPdi1 regulates pathogenicity of Fusarium oxysporum f. sp. niveum on watermelon., PMID:39708869
Selective Inhibition of Cytosolic PARylation via PARG99: A Targeted Approach for Mitigating FUS-associated Neurodegeneration., PMID:39651224
Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents., PMID:39615107
Effect of Culture Supernatant of Clostridium butyricum TO-A on Human DNA-Repair-Factor-Encoding Gene Promoters., PMID:39596217
Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models., PMID:39557132
Investigating the Structure of the Components of the PolyADP-Ribosylation System in Fusarium Fungi and Evaluating the Expression Dynamics of Its Key Genes., PMID:39555176
PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer., PMID:39546575
PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)., PMID:39536748
PARG inhibition induces nuclear aggregation of PARylated PARP1., PMID:39406247
Nphos: Database and Predictor of Protein N-phosphorylation., PMID:39380205
Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG., PMID:39342999
Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro., PMID:39278937
Adaptive genetic mechanisms in mammalian Parp1 locus., PMID:39056235
Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation., PMID:39015544
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks., PMID:38987289
ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines., PMID:38985679
Intrinsic signaling pathways modulate targeted protein degradation., PMID:38956052
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity., PMID:38897003
PARG Protein Regulation Roles in Drosophila Longevity Control., PMID:38892377
CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer., PMID:38862485
Kinetics of Human Serum Albumin Adsorption on Polycation Functionalized Silica., PMID:38785938
Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG., PMID:38762517
Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation., PMID:38749191
The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus Fusarium oxysporum f. sp. niveum., PMID:38690366
Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer., PMID:38580335
DePARylation is critical for S phase progression and cell survival., PMID:38578205
Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway., PMID:38452845
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence., PMID:38368415
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair., PMID:38360994
BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery., PMID:38357296
Magnetically navigated microbubbles coated with albumin/polyarginine and superparamagnetic iron oxide nanoparticles., PMID:38227987
Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells., PMID:38048727
Comprehensive Genomic Analysis of Cemento-Ossifying Fibroma., PMID:37995913
Poly(ADP-ribosyl)ating enzymes coordinate changes in the expression of metabolic genes with developmental progression., PMID:37985852
Strategies for the Management of Patients with Pancreatic Cancer with PARP Inhibitors., PMID:37978134
ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification., PMID:37898399
O-GlcNAc has crosstalk with ADP-ribosylation via PARG., PMID:37858678
The interplay of TARG1 and PARG protects against genomic instability., PMID:37676774
DePARylation is critical for S phase progression and cell survival., PMID:37577639
Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase., PMID:37507586
PARG Promotes Esophagus Cancer Cell Metastasis by Activation of the Wnt/β-Catenin Pathway., PMID:37429965
For research use only. Not for human or drug use.
