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Research Grade Rozanolixizumab

Catalog #:   DHF14602 Specific References (64) DATASHEET
Host species: Humanized
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHF14602

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P55899

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

UCB-7665, CAS: 1584645-37-3

Clone ID

Rozanolixizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Rozanolixizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Efficacy and Safety of Rozanolixizumab in Moderate to Severe Generalized Myasthenia Gravis: A Phase 2 Randomized Control Trial, PMID: 33219142

The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study, PMID: 29093180

Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration, PMID: 30130439

Phase 2 multiple-dose study of an FcRn inhibitor, rozanolixizumab, in patients with primary immune thrombocytopenia, PMID: 32886753

Next-generation Fc receptor-targeting biologics for autoimmune diseases, PMID: 31404703

Progress in the therapy of myasthenia gravis: getting closer to effective targeted immunotherapies, PMID: 32833750

Autoimmune thrombocytopenia: Current treatment options in adults with a focus on novel drugs, PMID: 31449692

Current pharmacotherapeutic options for myasthenia gravis, PMID: 31670984

Erratum for the Research Article: "The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study" by P. Kiessling, R. Lledo-Garcia, S. Watanabe, G. Langdon, D. Tran, M. Bari, L. Christodoulou, E. Jones, G. Price, B. Smith, F. Brennan, I. White, S. Jolles, PMID: 29212714

Therapies Directed Against B-Cells and Downstream Effectors in Generalized Autoimmune Myasthenia Gravis: Current Status, PMID: 30762205

[Reaserch Advances in the Treatment of Primary Immune Thrombocytopenia--Review], PMID: 34105504

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting the Effects of Anti-FcRn Therapy on the Disposition of Endogenous IgG in Humans, PMID: 30471293

The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors, PMID: 33717213

Antiseizure Medication use in Gastric Bypass Patients and Other Post-Surgical Malabsorptive States, PMID: 33997757

FcRn inhibitors in immune thrombocytopenia: A comprehensive review of therapeutic advances and clinical outcomes., PMID:40505332

From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis., PMID:40447786

Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics., PMID:40292035

Efficacy and safety of FcRn inhibitors in patients with Myasthenia gravis: An updated systematic review and meta‑analysis., PMID:40288289

Rozanolixizumab for Myasthenia Gravis: a breakthrough treatment and future prospects., PMID:40277145

Real-World Experience with FcRn Inhibitors Efgartigimod and Rozanolixizumab in Myasthenia Gravis: Administration in Multiple Cycles and Transition from Intravenous to Subcutaneous Formulation., PMID:40257679

Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024., PMID:40206093

Rising to the challenge: an international Delphi consensus study on fetal and neonatal alloimmune thrombocytopenia., PMID:40175002

Ventral Subpial and Central Cord Enhancement in Spinal Neurosarcoidosis: The Reverse Trident Sign., PMID:40168633

Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study., PMID:40105996

Long-term safety of cyclical rozanolixizumab in patients with generalized myasthenia gravis: Results from the Phase 3 MycarinG study and an open-label extension., PMID:40034001

Rozanolixizumab in generalized myasthenia gravis: Pooled analysis of the Phase 3 MycarinG study and two open-label extensions., PMID:40033991

Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD., PMID:39932929

Real-world clinical experience with serum MOG and AQP4 antibody testing by live versus fixed cell-based assay., PMID:39901660

FcRn inhibitors in the context of myasthenia gravis., PMID:39870595

Testing for myelin oligodendrocyte glycoprotein antibodies: Who, what, where, when, why, and how., PMID:39861933

Curriculum Innovations: A Novel Neurology Clinician-Educator Program., PMID:39748890

Evaluation of the effect of rozanolixizumab on pregnancy outcomes and pre- and postnatal development in cynomolgus monkeys., PMID:39709064

Advances in Disease-Modifying Therapeutics for Chronic Neuromuscular Disorders., PMID:39708835

Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria., PMID:39708293

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Neonatal Fc Receptor Inhibitor Rozanolixizumab: An Ethnic Sensitivity Study in Healthy Japanese, Chinese, and White Participants., PMID:39569616

Inhibition of FcRn with rozanolixizumab in adults with immune thrombocytopenia: Two randomised, double-blind, placebo-controlled phase 3 studies and their open-label extension., PMID:39552477

Initiation response, maximized therapeutic efficacy, and post-treatment effects of biological targeted therapies in myasthenia gravis: a systematic review and network meta-analysis., PMID:39529623

Risk-Benefit Analysis of Novel Treatments for Patients with Generalized Myasthenia Gravis., PMID:39470879

Pediatric MOG-Ab-Associated Encephalitis: Supporting Early Recognition and Treatment., PMID:39393046

Comprehensive Analysis of Paraneoplastic Neurologic Syndrome and PNS-CARE Diagnostic Criteria in Clinical Practice., PMID:39321395

Efficacy and safety of rozanolixizumab in patients with muscle-specific tyrosine kinase autoantibody-positive generalised myasthenia gravis: a subgroup analysis of the randomised, double-blind, placebo-controlled, adaptive phase III MycarinG study., PMID:39297052

Intracranial Pressure Elevation and MOGAD., PMID:39283648

Long-term outcomes in antibody-negative autoimmune encephalitis: a retrospective study., PMID:39278895

Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms., PMID:39237493

Targeted Treatments for Myasthenia Gravis in Children and Adolescents., PMID:39198371

Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network., PMID:39099240

Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). I. Drugs in preclinical and early clinical development., PMID:39008349

Clinical meaningfulness and psychometric robustness of the MG Symptoms PRO scales in clinical trials in adults with myasthenia gravis., PMID:38978809

Efgartigimod as Rescue Medication in a Patient with Therapy-Refractory Myasthenic Crisis., PMID:38939234

Efficacy, safety and tolerability of rozanolixizumab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a randomised, subject-blind, investigator-blind, placebo-controlled, phase 2a trial and open-label extension study., PMID:38729747

FcRn Inhibitor Therapies in Neurologic Diseases., PMID:38724842

MOG Antibody-Associated Disease in the Setting of Metastatic Melanoma Complicated by Immune Checkpoint Inhibitor Use., PMID:38696737

Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity-a potential diagnostic pitfall in patients with MOG-EM/MOGAD., PMID:38609667

Zilucoplan (Zilbrysq) for myasthenia gravis., PMID:38576149

Rozanolixizumab: A New Therapy in the Treatment of Myasthenia Gravis., PMID:38533739

Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis., PMID:38506182

Batoclimab vs Placebo for Generalized Myasthenia Gravis: A Randomized Clinical Trial., PMID:38436998

The efficacy and safety of FcRn inhibitors in patients with myasthenia gravis: a systematic review and meta-analysis., PMID:38431900

Rozanolixizumab (Rystiggo) for myasthenia gravis., PMID:38412267

The Efficacy and Safety of Different Targeted Drugs for the Treatment of Generalized Myasthenia Gravis: A Systematic Review and Bayesian Network Meta-analysis., PMID:38300476

Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro., PMID:38241085

Peripheral nervous system manifestations of MOG antibody associated disease., PMID:38234084

Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future., PMID:38212553

Antibodies to watch in 2024., PMID:38178784

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1314

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For research use only. Not for human or drug use.

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Research Grade Rozanolixizumab [DHF14602]
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