Catalog No.
YHJ13801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser347
Predicted molecular weight
38.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7Z434
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interferon beta promoter stimulator protein 1, IPS-1, IPS1, KIAA1271, VISA, CARD adapter inducing interferon beta, Mitochondrial antiviral-signaling protein, Virus-induced-signaling adapter, Cardif, Putative NF-kappa-B-activating protein 031N, MAVS
EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response., PMID:40514071
The macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses., PMID:40493408
The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes., PMID:40489607
Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation., PMID:40483467
Enhancement of MAVS UFMylation and inhibition of lysosomal degradation of MAVS aggregates: New findings on broad-spectrum antiviral mechanism of Anemoside B4., PMID:40466952
Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice., PMID:40456736
Mitochondrial Antiviral Signaling Protein Activation by Retinoic Acid-Inducible Gene I Agonist Triggers Potent Antiviral Defense in Umbilical Cord Mesenchymal Stromal Cells Without Compromising Mitochondrial Function., PMID:40429828
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production., PMID:40404827
Enterovirus 71 Induces Mitophagy via PINK1/Parkin Signaling Pathway to Promote Viral Replication., PMID:40396408
PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection., PMID:40395521
Cell-Autonomous Immunity: From Cytosolic Sensing to Self-Defense., PMID:40362284
Mystery machine: the complex roles of NLRX1 in viral infection., PMID:40356929
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling., PMID:40339257
Genetic Variants in the NOD-like Receptor Signaling Pathway Are Associated with HIV-1/AIDS in a Northern Chinese Population., PMID:40331958
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses., PMID:40312484
ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization., PMID:40301689
Palmitoyl-transferase 3 promotes mitochondrial antiviral signaling protein degradation by modulating its ubiquitination., PMID:40300684
Yellow fever virus infection alters mitochondrial network dynamics and trigger IFN-I response via TLR2 pathway., PMID:40300356
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia., PMID:40299016
Berberine Suppresses Influenza A Virus-Triggered Pyroptosis in Macrophages via Intervening in the mtROS-MAVS-NLRP3 Inflammasome Pathway., PMID:40284982
ATP2A2 regulates STING1/MITA-driven signal transduction including selective autophagy., PMID:40265346
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy., PMID:40253768
AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain., PMID:40251179
mtDNA/RNA boosts radiation-induced abscopal effect via M1 macrophage polarization-promoted IFN-β-dependent inflammatory response., PMID:40245773
Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Enable Dissection of Key Mechanisms and Evolutionary Processes Underlying Viral Pathogenesis., PMID:40236211
PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS., PMID:40233407
CircARID1B Promotes MPP+-Induced Death and Inflammation in Dopaminergic Neurons by Elevating MAVS Through Sequestering miR-143-3p., PMID:40185987
ASFV pS183L protein negatively regulates RLR-mediated antiviral signalling by blocking MDA5 oligomerisation., PMID:40165208
The ELF3-TRIM22-MAVS signaling axis regulates type I interferon and antiviral responses., PMID:40162781
Mitochondria-dependent innate immunity: A potential therapeutic target in Flavivirus infection., PMID:40158432
ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation., PMID:40126553
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes., PMID:40121229
TLR4 mediates glucolipotoxicity-induced mitochondrial dysfunction in osteoblasts by enhancing NLRP3-MAVS expression and interaction., PMID:40101421
ZUP1 is a key component of the MAVS complex and acts as a protector of host against viral invasion., PMID:40095368
A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy., PMID:40085508
Genetic evidence for the suppressive role of zebrafish vhl targeting mavs in antiviral innate immunity during RNA virus infection., PMID:40073266
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity., PMID:40073244
E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production., PMID:40071916
The structural protein VP3 of enterovirus D68 interacts with MAVS to inhibit the NF-κB signaling pathway., PMID:40042308
Exploring the role of mitochondrial antiviral signaling protein in cardiac diseases., PMID:40040697
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells., PMID:40029556
IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS., PMID:40022729
Identification of a type I IFN- and IRF-inducible enhancer in the 5'-UTR intron of MAVS in large yellow croaker Larimichthys crocea., PMID:40020953
SARS-CoV-2 infection primes cross-protective respiratory IgA in a MyD88- and MAVS-dependent manner., PMID:40016252
Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity., PMID:40016186
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer., PMID:40000433
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses., PMID:39998221
For research use only. Not for human or drug use.
