Catalog No.
YHJ13001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe351
Predicted molecular weight
43.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7LG56
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p53R2, p53-inducible ribonucleotide reductase small subunit 2-like protein, P53R2, RRM2B, TP53-inducible ribonucleotide reductase M2 B, Ribonucleoside-diphosphate reductase subunit M2 B
RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis., PMID:40244665
Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome., PMID:40211788
Identifying ribonucleotide reductase subunit genes as potential lung adenocarcinomas biomarkers using integrated bioinformatics analysis., PMID:40191558
Investigating the safety and efficacy of deoxycytidine/deoxythymidine in mitochondrial DNA depletion disorders: phase 2 open-label trial., PMID:40175578
RRM1 O-GlcNAcylation inhibition suppresses pancreatic cancer via TK1-mediated replication stress., PMID:40155654
p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis., PMID:39315696
Identification of a new human senescent skin cell marker ribonucleoside-diphosphate reductase subunit M2 B., PMID:39261410
Mutation spectrum of hearing loss patients in Northwest China: Identification of 20 novel variants., PMID:38860500
A comprehensive analysis of ribonucleotide reductase subunit M2 for carcinogenesis in pan-cancer., PMID:38635758
N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA., PMID:38549713
Proteomic-metabolomic combination analysis reveals novel biomarkers of meat quality that differ between young and older ducks., PMID:38417328
Ribonucleotide reductase inhibition improves the symptoms of a Caenorhabditis elegans model of Alzheimer's disease., PMID:38412549
Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma., PMID:37955686
Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes., PMID:37616596
Diagnosing mitochondrial, neurogastrointestinal leukoencephalopathy requires mutations in TYMP1, POLG1, LIG1, or RRM2B., PMID:37055871
Identification of two novel RRM2B variants associated with autosomal recessive progressive external ophthalmoplegia in a family with pseudodominant inheritance pattern., PMID:36959467
Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse., PMID:36882565
Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer., PMID:36713030
Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition., PMID:36394520
A novel thymidine phosphorylase mutation in a family with Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): Molecular docking, dynamic simulation and computational investigations., PMID:35841120
Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes., PMID:35204825
Serum level and tumor tissue expression of Ribonucleotide-diphosphate Reductase subunit M2 B: a potential biomarker for colorectal cancer., PMID:35129765
[Clinical characteristics and genetic analysis of a Chinese pedigree affected with mitochondrial DNA depletion syndrome due to compound heterozygous variants of RRM2B gene]., PMID:34964961
Saccharomyces cerevisiae as a Tool for Studying Mutations in Nuclear Genes Involved in Diseases Caused by Mitochondrial DNA Instability., PMID:34946817
A Yeast-Based Repurposing Approach for the Treatment of Mitochondrial DNA Depletion Syndromes Led to the Identification of Molecules Able to Modulate the dNTP Pool., PMID:34830106
Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein., PMID:34599703
Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells., PMID:34443490
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment., PMID:34439352
Isozymes of P5C reductase (PYCR) in human diseases: focus on cancer., PMID:34291342
Mitochondrial Retinopathy., PMID:34257060
RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy., PMID:33868369
Mitochondrial DNA maintenance disorders in 102 patients from different parts of Russia: Mutational spectrum and phenotypes., PMID:33486010
The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation., PMID:32931159
Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out., PMID:32876667
Renal dysfunction, rod-cone dystrophy, and sensorineural hearing loss caused by a mutation in RRM2B., PMID:32827185
Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study., PMID:32775440
Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome., PMID:32750454
Reflections on Charlie Gard and the Best Interests Standard From Both Sides of the Atlantic Ocean., PMID:32737234
NAIGO: An Improved Method to Align PPI Networks Based on Gene Ontology and Graphlets., PMID:32637398
Genomic analyses of early responses to radiation inglioblastoma reveal new alterations at transcription,splicing, and translation levels., PMID:32488114
Clinical, pathological and genetic spectrum in 89 cases of mitochondrial progressive external ophthalmoplegia., PMID:32161153
Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late-onset disorder of mitochondrial DNA maintenance., PMID:31600844
TP53 mutations and relevance of expression of TP53 pathway genes in paediatric acute myeloid leukaemia., PMID:31588562
Rrm2b deletion causes mitochondrial metabolic defects in renal tubules., PMID:31519977
The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency., PMID:31462754
Integration of Metabolomics and Transcriptomics To Reveal Metabolic Characteristics and Key Targets Associated with Cisplatin Resistance in Nonsmall Cell Lung Cancer., PMID:31373204
Congenital cochlear deafness in mitochondrial diseases related to RRM2B and SERAC1 gene defects. A study of the mitochondrial patients of the CMHI hospital in Warsaw, Poland., PMID:30909120
[Phenotype and genotype of twelve Chinese children with mitochondrial DNA depletion syndromes]., PMID:30818899
Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer., PMID:30662615
A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death., PMID:30439532
For research use only. Not for human or drug use.
