Catalog No.
YHJ12601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met57-Phe179
Predicted molecular weight
40.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7L591
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes., PMID:39726593
Circulating monocyte adhesion repairs endothelium-denuded injury through downstream of kinase 3-mediated endothelialization., PMID:39689764
Combining bioinformatics and machine learning to identify diagnostic biomarkers of TB associated with immune cell infiltration., PMID:39418810
Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model., PMID:39147036
Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer., PMID:39072170
Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China., PMID:38671413
DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11., PMID:37906628
Expression and clinical significance of DOK3 in renal clear cell carcinoma., PMID:37235715
DOK3 promotes proliferation and inhibits apoptosis of prostate cancer via the NF-κB signaling pathway., PMID:36867541
Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea)., PMID:36768499
Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765
The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells., PMID:36361992
Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma., PMID:36210538
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein., PMID:36172386
Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment., PMID:36028467
Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors., PMID:35127166
Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers., PMID:34933256
Tumor antigens and immune subtypes guided mRNA vaccine development for kidney renal clear cell carcinoma., PMID:34872567
ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3., PMID:34820053
DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils., PMID:34743196
Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis., PMID:34245977
DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84., PMID:33281117
Emerging Roles of Downstream of Kinase 3 in Cell Signaling., PMID:33133079
Linking TPPII to the protein interaction and signalling networks., PMID:32702546
Gene Expression Profiling of Mediators Associated with the Inflammatory Pathways in the Intestinal Tissue from Patients with Ulcerative Colitis., PMID:32410873
Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas., PMID:32193105
Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice., PMID:31970902
Dok-3 deficient mice display different immune clustering and Tim-3 expression., PMID:31351483
Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity., PMID:31180338
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia., PMID:29548825
DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis., PMID:28650106
Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice., PMID:28302940
What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling., PMID:27813071
Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer., PMID:27354594
Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells., PMID:27265473
DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice., PMID:28590889
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer., PMID:26585945
TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNFα in TLR9 signaling., PMID:26548852
Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease., PMID:26202100
Dok proteins are recruited to the phagosome and degraded in a GP63-dependent manner during Leishmania major infection., PMID:25554486
Hypertensive renal injury is associated with gene variation affecting immune signaling., PMID:25366137
Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands., PMID:25053811
DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation., PMID:24929003
A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages., PMID:23962980
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters., PMID:23223229
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., PMID:23205702
DOK3 negatively regulates LPS responses and endotoxin tolerance., PMID:22761938
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster., PMID:21703542
Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells., PMID:21262349
For research use only. Not for human or drug use.
