Catalog No.
YHJ12601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met57-Phe179
Predicted molecular weight
40.30 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7L591
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Note
For research use only.
Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells., PMID:21262349
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster., PMID:21703542
DOK3 negatively regulates LPS responses and endotoxin tolerance., PMID:22761938
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., PMID:23205702
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters., PMID:23223229
A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages., PMID:23962980
DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation., PMID:24929003
Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands., PMID:25053811
Hypertensive renal injury is associated with gene variation affecting immune signaling., PMID:25366137
Dok proteins are recruited to the phagosome and degraded in a GP63-dependent manner during Leishmania major infection., PMID:25554486
Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease., PMID:26202100
TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNFα in TLR9 signaling., PMID:26548852
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer., PMID:26585945
DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice., PMID:28590889
Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells., PMID:27265473
Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer., PMID:27354594
What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling., PMID:27813071
Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice., PMID:28302940
DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis., PMID:28650106
Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia., PMID:29548825
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity., PMID:31180338
Dok-3 deficient mice display different immune clustering and Tim-3 expression., PMID:31351483
Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice., PMID:31970902
Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas., PMID:32193105
Gene Expression Profiling of Mediators Associated with the Inflammatory Pathways in the Intestinal Tissue from Patients with Ulcerative Colitis., PMID:32410873
Linking TPPII to the protein interaction and signalling networks., PMID:32702546
Emerging Roles of Downstream of Kinase 3 in Cell Signaling., PMID:33133079
DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84., PMID:33281117
Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis., PMID:34245977
DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils., PMID:34743196
ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3., PMID:34820053
Tumor antigens and immune subtypes guided mRNA vaccine development for kidney renal clear cell carcinoma., PMID:34872567
Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers., PMID:34933256
Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors., PMID:35127166
Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment., PMID:36028467
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein., PMID:36172386
Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma., PMID:36210538
The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells., PMID:36361992
Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765
Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea)., PMID:36768499
DOK3 promotes proliferation and inhibits apoptosis of prostate cancer via the NF-κB signaling pathway., PMID:36867541
Expression and clinical significance of DOK3 in renal clear cell carcinoma., PMID:37235715
DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11., PMID:37906628
Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China., PMID:38671413
Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer., PMID:39072170
Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model., PMID:39147036
Combining bioinformatics and machine learning to identify diagnostic biomarkers of TB associated with immune cell infiltration., PMID:39418810
Circulating monocyte adhesion repairs endothelium-denuded injury through downstream of kinase 3-mediated endothelialization., PMID:39689764
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes., PMID:39726593
For research use only. Not for human or drug use.
