Catalog No.
YHJ11001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu1216-Ala1374
Predicted molecular weight
18.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6ZMQ8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lemur tyrosine kinase 1, Serine/threonine-protein kinase LMTK1, LMR1, p35BP, LMTK1, AATK, Brain apoptosis-associated tyrosine kinase, p35-binding protein, AATYK, Apoptosis-associated tyrosine kinase, KIAA0641, CDK5-binding protein
Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer., PMID:40227503
Downregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells., PMID:39871626
Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases., PMID:39415254
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families., PMID:36344539
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner., PMID:35902728
Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1., PMID:34523681
miR-1250-5p is a novel tumor suppressive intronic miRNA hypermethylated in non-Hodgkin's lymphoma: novel targets with impact on ERK signaling and cell migration., PMID:34044822
Hyperactive and impulsive behaviors of LMTK1 knockout mice., PMID:32963255
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer., PMID:32552862
Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation., PMID:32044995
The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking., PMID:31628178
AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination., PMID:29556912
DNA trinucleotide (GAA) repeats in human genome: hint for disease pathogenesis?, PMID:28605995
Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons., PMID:27600567
Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy., PMID:27485693
miR-338 inhibits the metastasis of lung cancer by targeting integrin β3., PMID:27431198
A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia., PMID:26154020
Transcriptomic Analysis of mRNAs in Human Monocytic Cells Expressing the HIV-1 Nef Protein and Their Exosomes., PMID:25961023
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers., PMID:25864925
Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion., PMID:25751313
LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes., PMID:24672056
Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma., PMID:24589855
Compensatory β-cell mass expansion: a big role for a tiny actor., PMID:23287464
LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner., PMID:22573681
A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase., PMID:22363537
Developmental regulation of microRNA expression in Schwann cells., PMID:22064487
Systematizing and cloning of genes involved in the cerebellar cortex circuit development., PMID:21243430
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation., PMID:20422042
An intronic microRNA silences genes that are functionally antagonistic to its host gene., PMID:18684991
A promoter sequence variant of ZNF750 is linked with familial psoriasis., PMID:18256691
Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation., PMID:17267545
Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon., PMID:16969489
Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells., PMID:16100393
Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling., PMID:15005709
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein., PMID:14521924
Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein., PMID:12884081
Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain., PMID:12670708
Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS., PMID:11314040
Characterization of an alternatively spliced AATYK mRNA: expression pattern of AATYK in the brain and neuronal cells., PMID:11314039
A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line., PMID:10837911
Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization., PMID:10083745
For research use only. Not for human or drug use.
