Catalog No.
YHJ09901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu20-Arg565
Predicted molecular weight
62.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UXI9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein EGFL6-like, NPNT, POEM, EGFL6L, Preosteoblast EGF-like repeat protein with MAM domain, Nephronectin
Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis., PMID:40444575
Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins., PMID:40421300
Characterisation of a COPD-associated nephronectin (NPNT) functional splicing genetic variant in human lung tissue via long-read sequencing., PMID:39978861
Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals., PMID:39418301
Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan., PMID:38935874
Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression., PMID:38640019
Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis., PMID:38246333
Alternative splicing in lung influences COVID-19 severity and respiratory diseases., PMID:37794074
A chlorogenic acid-chitosan complex bifunctional coating for improving osteogenesis differentiation and bactericidal properties of zirconia implants., PMID:37540946
m6A epitranscriptomic regulation of tissue homeostasis during primate aging., PMID:37118553
Causal associations and shared genetics between hypertension and COVID-19., PMID:36951353
LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis., PMID:36870548
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity., PMID:36805566
High-fiber-diet-related metabolites improve neurodegenerative symptoms in patients with obesity with diabetes mellitus by modulating the hippocampal-hypothalamic endocrine axis., PMID:36733447
Nephronectin is required to maintain right lung lobar separation during embryonic development., PMID:36719987
The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms., PMID:36462719
Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract., PMID:36292572
miR-378 associated with proliferation, migration and apoptosis properties in A549 cells and targeted NPNT in COPD., PMID:36128198
Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR/JAK2/STAT3 pathway., PMID:35693734
Endotoxin-induced acute lung injury in mice with postnatal deletion of nephronectin., PMID:35552565
Integrated analysis identified NPNT as a potential key regulator in tumor metastasis of hepatocellular carcinoma., PMID:35304239
Whole-exome sequencing in a Japanese multiplex family identifies new susceptibility genes for intracranial aneurysms., PMID:35299232
A null founder variant in NPNT, encoding nephronectin, causes autosomal recessive renal agenesis., PMID:35246978
Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development., PMID:35238772
Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species., PMID:35235429
A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes., PMID:35011710
Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis., PMID:34716242
A cell-ECM mechanism for connecting the ipsilateral eye to the brain., PMID:34654745
Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors., PMID:34645824
LncRNA ENSMUST00000155383 is Involved in the Improvement of DPP-4 Inhibitor MK-626 on Vascular Endothelial Function by Modulating Cacna1c-Mediated Ca2+ Influx in Hypertensive Mice., PMID:34368236
A Biallelic Frameshift Mutation in Nephronectin Causes Bilateral Renal Agenesis in Humans., PMID:34049960
BRG1 Mediates Nephronectin Activation in Hepatocytes to Promote T Lymphocyte Infiltration in ConA-Induced Hepatitis., PMID:33553140
Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells., PMID:33543041
Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing., PMID:33173926
Identification of nephronectin as a new target for IGF1 action., PMID:33130549
Nephronectin is a prognostic biomarker and promotes gastric cancer cell proliferation, migration and invasion., PMID:32935851
Embryonic ECM Protein SLIT2 and NPNT Promote Postnatal Cardiomyocyte Cytokinesis., PMID:32910739
Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains., PMID:32699247
Identification key genes, key miRNAs and key transcription factors of lung adenocarcinoma., PMID:32642095
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix., PMID:32564729
Antibodies against nephronectin ameliorate anti-type II collagen-induced arthritis in mice., PMID:31705832
[Recent advances in nephronectin]., PMID:31646334
Role of Nephronectin in Pathophysiology of Silicosis., PMID:31130697
A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells., PMID:30707844
NPNT promotes early-stage bone metastases in breast cancer by regulation of the osteogenic niche., PMID:30591862
Nephronectin mediates p38 MAPK-induced cell viability via its integrin-binding enhancer motif., PMID:30524949
Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts., PMID:30341591
Nephronectin (NPNT) and the prediction of nephrotic syndrome response to steroid treatment., PMID:29891875
Conceptus Coats of Marsupials and Monotremes., PMID:29853183
FGF-2 suppresses expression of nephronectin via JNK and PI3K pathways., PMID:29744297
For research use only. Not for human or drug use.
