Catalog No.
YHJ07601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser245-Glu396
Predicted molecular weight
20.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6PL18
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2, ATPase family AAA domain-containing protein 2
BRD9 functions as an HIV-1 latency regulatory factor., PMID:40402245
ATAD2 bromodomain in cancer therapy: current status and future perspectives., PMID:40334884
Competitive binding between DDX21 and SIRT7 enhances NAT10-mediated ac4C modification to promote colorectal cancer metastasis and angiogenesis- DDX21 promotes colorectal cancer metastasis., PMID:40301349
ATAD2 Drives Prostate Cancer Progression to Metastasis., PMID:39907729
ATAD2 is a potential immunotherapy target for patients with small cell lung cancer harboring HLA-A∗0201., PMID:39808946
Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL., PMID:39785511
ATAD2 and TWIST1 Interaction Promotes MYC Activation in Colorectal Carcinoma., PMID:39686835
FOXM1 Transcriptionally Co-Upregulates Centrosome Amplification and Clustering Genes and Is a Biomarker for Poor Prognosis in Androgen Receptor-Low Triple-Negative Breast Cancer., PMID:39335162
Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma., PMID:39333272
Role and Regulatory Mechanism of circRNA_14820 in the Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells., PMID:39201586
Assessment of Recovery Time Effects on Human Primary Neonatal Dermal Fibroblasts After Exposure to Solar-Simulated Ultraviolet Radiation., PMID:39050996
Elevated expression of ECT2 as a diagnostic marker and prognostic indicator in endometrial cancer., PMID:38977110
Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains., PMID:38733345
Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells., PMID:38730681
PharmaCore: The Automatic Generation of 3D Structure-Based Pharmacophore Models from Protein/Ligand Complexes., PMID:38728062
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma., PMID:38378000
Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women., PMID:37922300
Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication., PMID:37770645
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2., PMID:37595446
Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells., PMID:37533352
ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE., PMID:37479754
Predicted Configuration and Stability of the ATAD2/SOX10 Complex Using Molecular Dynamics Simulations., PMID:37168970
Identification of POLQ as a key gene in cervical cancer progression using integrated bioinformatics analysis and experimental validation., PMID:37114556
Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential., PMID:37046768
Bromodomain (BrD) Family Members as Regulators of Cancer Stemness-A Comprehensive Review., PMID:36674511
ATPase family AAA domain-containing protein 2 (ATAD2): From an epigenetic modulator to cancer therapeutic target., PMID:36632213
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair., PMID:36629267
ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration., PMID:36479043
Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2., PMID:36404917
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions., PMID:36367089
Exiting the tunnel of uncertainty: crystal soak to validated hit., PMID:36322414
ATAD2 suppression enhances the combinatorial effect of gemcitabine and radiation in pancreatic cancer cells., PMID:36279679
A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer., PMID:36151333
miR-302 Suppresses the Proliferation, Migration, and Invasion of Breast Cancer Cells by Downregulating ATAD2., PMID:36139505
Exosomal microRNA-506 inhibits biological activity of lung adenocarcinoma cells and increases sensitivity to cisplatin-based hyperthermia., PMID:36115547
Aspirin Exerts Its Antitumor Effect in Esophageal Squamous Cell Carcinoma by Downregulating the Expression of ATAD2 and KIF4A., PMID:36046597
Identification of novel key genes and potential candidate small molecule drugs in diabetic kidney disease using comprehensive bioinformatics analysis., PMID:36035169
Tumor-Promoting ATAD2 and Its Preclinical Challenges., PMID:36008934
Integrated Analysis of mRNAs and Long Non-Coding RNAs Expression of Oviduct That Provides Novel Insights into the Prolificacy Mechanism of Goat (Capra hircus)., PMID:35741792
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4., PMID:35705032
Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness., PMID:35672694
MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2., PMID:35504332
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models., PMID:35133824
ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors., PMID:35085891
The association between bromodomain proteins and cancer stemness in different solid tumor types., PMID:35049055
Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase., PMID:34973392
Evaluation of ATAD2 as a Potential Target in Hepatocellular Carcinoma., PMID:34738187
ATAD2 controls chromatin-bound HIRA turnover., PMID:34580178
Developmental chromatin programs determine oncogenic competence in melanoma., PMID:34516843
Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain., PMID:34502039
For research use only. Not for human or drug use.
