Catalog No.
YHJ07001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro162-Asn347
Predicted molecular weight
23.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6P1Q0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HCCR-1, Cervical cancer proto-oncogene 2 protein, Cervical cancer 1 proto-oncogene protein p40, HCRR-2, LETMD1, LETM1 domain-containing protein 1
LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes., PMID:39897567
LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function., PMID:39398236
LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis., PMID:37769890
Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice., PMID:37353518
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology., PMID:36334589
MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1., PMID:35818268
The regulating role of miR-494 on HCCR1 in cervical cancer cells., PMID:35818261
Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue., PMID:35817133
Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1., PMID:34910916
LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes., PMID:34669999
Knockdown of SNHG1 inhibits cervical cancer growth through sponging miR-194 to regulate HCCR., PMID:32456490
LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages., PMID:31980577
Interaction of HCCR-1 and Bax in breast cancer., PMID:31424657
Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3., PMID:27052330
Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression., PMID:26629942
Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin., PMID:26470691
The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice., PMID:25586139
Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia., PMID:25034723
Silencing HCCR2 expression inhibits the proliferation of leukemia cells by inducing apoptosis and promoting cell cycle arrest., PMID:24126909
HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers., PMID:22851403
Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma., PMID:22511601
Combined analysis of AFP and HCCR-1 as an useful serological marker for small hepatocellular carcinoma: a prospective cohort study., PMID:22430193
[Preparation and characterization of monoclonal antibody against HCCR protein]., PMID:21968311
Simultaneous measurements of serum AFP, GPC-3 and HCCR for diagnosing hepatocellular carcinoma., PMID:21940340
Silencing of the HCCR2 gene induces apoptosis and suppresses the aggressive phenotype of hepatocellular carcinoma cells in culture., PMID:21796456
Clinical utility of alpha fetoprotein and HCCR-1, alone or in combination, in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma., PMID:21725159
Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy., PMID:21703393
Immortalized cells and one oncogene in malignant transformation: old insights on new explanation., PMID:21605454
[HCCR-2 enhances the division and proliferation of SMMC 7721 via PI3K/Akt pathway]., PMID:21138632
Transdifferentiation-inducing HCCR-1 oncogene., PMID:20591135
Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells., PMID:20423485
Novel components of an active mitochondrial K(+)/H(+) exchange., PMID:20197279
Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity., PMID:20196787
TCF/beta-catenin plays an important role in HCCR-1 oncogene expression., PMID:19435525
Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status., PMID:19208263
[The inhibition effect and its molecular mechanism of human cervical cancer oncogene siRNA on hepatocarcinoma cells]., PMID:18752750
HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis., PMID:18045496
[Overexpression of HCCR in hepatocellular carcinoma cells and its clinical significance]., PMID:17407719
The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression., PMID:16949218
[Cloning, prokaryotic expression and polyclonal antibody preparation of HCCR: a new biomarker for hepatocellular carcinoma]., PMID:16494777
The HCCR oncoprotein as a biomarker for human breast cancer., PMID:16278390
Novel oncogene HCCR: its diagnostic and therapeutic implications for cancer., PMID:15944950
The human cervical cancer oncogene protein is a biomarker for human hepatocellular carcinoma., PMID:15289352
Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice., PMID:14691448
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization., PMID:12879013
For research use only. Not for human or drug use.
