Catalog No.
YHJ05501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile34-Asn263
Predicted molecular weight
51.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6GPI1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTRB2, Chymotrypsinogen B2
A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice., PMID:40254337
Engineering mouse chymotrypsin B1 for improved trypsinogen degradation., PMID:40133496
Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome., PMID:39933395
A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice., PMID:39211105
Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis., PMID:38427138
Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens., PMID:37931399
Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors., PMID:37604733
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma., PMID:36116415
Genetic regulation of RNA splicing in human pancreatic islets., PMID:36109769
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis., PMID:35934298
A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer., PMID:34559995
Mouse model suggests limited role for human mesotrypsin in pancreatitis., PMID:33526384
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer., PMID:33517887
Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis., PMID:33036922
Chronic pancreatitis: an update on genetic risk factors., PMID:29901518
Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma., PMID:29615326
Genome-wide analysis of disease progression in age-related macular degeneration., PMID:29346644
Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex., PMID:29302047
Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†., PMID:28011711
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2., PMID:27358403
Pharmacogenetic aspects of the treatment of Type 2 diabetes with the incretin effect enhancers., PMID:27166975
Low-protein diets affect ileal amino acid digestibility and gene expression of digestive enzymes in growing and finishing pigs., PMID:26210756
Differences between clinical and laboratory findings in patients with recent diagnosis of SLE according to the positivity of anti-dsDNA by the Crithidia luciliae method., PMID:25716418
Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos., PMID:25629157
Identification of genes with consistent methylation levels across different human tissues., PMID:24619003
Functional enrichment by direct plasmid recovery after fluorescence activated cell sorting., PMID:26345509
Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight., PMID:23970522
Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop., PMID:23814066
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway., PMID:23674605
Mechanisms of formation of structural variation in a fully sequenced human genome., PMID:23086744
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen., PMID:23035638
Recombinant Lucilia sericata chymotrypsin in a topical hydrogel formulation degrades human wound eschar ex vivo., PMID:21509949
Identification of pancreatic juice proteins as biomarkers of pancreatic cancer., PMID:20428826
Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid., PMID:20361227
Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway., PMID:18211899
The crystal structure of a trypsin-like mutant chymotrypsin: the role of position 226 in the activity and specificity of S189D chymotrypsin., PMID:17805946
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen., PMID:16505482
Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease., PMID:15047908
Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas., PMID:12409833
Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin., PMID:11733020
Molecular cloning of the Atlantic cod chymotrypsinogen B., PMID:11011764
Biochemical evidence of specific trypsin-chymotrypsin inhibitors in the rhynchobdellid leech, Theromyzon tessulatum., PMID:10995068
The differential specificity of chymotrypsin A and B is determined by amino acid 226., PMID:9914536
Serine proteases in rodent hippocampus., PMID:9722524
A novel human chymotrypsin-like digestive enzyme., PMID:9065485
The major excretory/secretory protease from Lucilia cuprina larvae is also a gut digestive protease., PMID:8875307
Excretory/secretory chymotrypsin from Lucilia cuprina: purification, enzymatic specificity and amino acid sequence deduced from mRNA., PMID:7704304
Structure of the canine pancreatic colipase gene includes two protein-binding sites in the promoter region., PMID:7684378
Assignment of disulphide bonds in synthetic endothelin-1 isomers by fast atom bombardment mass spectrometry., PMID:1799581
The chymotrypsin enhancer core. Specific factor binding and biological activity., PMID:2584237
For research use only. Not for human or drug use.
