Catalog No.
YHJ04301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr322
Predicted molecular weight
37.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q68CJ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CREBH, Transcription factor CREB-H, cAMP-responsive element-binding protein 3-like protein 3, Cyclic AMP-responsive element-binding protein 3-like protein 3, CREB3L3
Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic de novo lipogenesis by mediating epididymal fat insulin resistance., PMID:40303310
Cascade screening of a Pakistani consanguineous familial hypercholesterolemia cohort: Identification of seven new homozygous patients., PMID:39903948
Insulin Resistance Mediates the Association Between Vitamin D and Non-Alcoholic Fatty Liver Disease., PMID:39867257
[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology]., PMID:39701680
ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis., PMID:39589874
Hypertriglyceridemia-induced acute pancreatitis in pregnancy associated with CREB3L3 mutation., PMID:39562229
Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis., PMID:39019116
CREB3 suppresses hepatocellular carcinoma progression by depressing AKT signaling through competitively binding with insulin receptor and transcriptionally activating RNA-binding motif protein 38., PMID:38952575
CREB3 mediates the transcriptional regulation of PGC-1α, a master regulator of energy homeostasis and mitochondrial biogenesis., PMID:38697949
Molecular characterization of transcription factor CREB3L2 and CREB3L3 and their role in melanogenesis in Pacific oysters (Crassostrea gigas)., PMID:38604561
Evaluation of serum and urine biomarkers for severe COVID-19., PMID:38510452
Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor., PMID:38291529
Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting., PMID:37940485
Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers., PMID:37595431
CREB-H is a stress-regulator of hepcidin gene expression during early postnatal development., PMID:37493829
Transcriptomics reveals key regulatory pathways and genes associated with skin diseases induced by face paint usage., PMID:37236445
REDD1 deletion and treadmill running increase liver hepcidin and gluconeogenic enzymes in male mice., PMID:37123395
Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank., PMID:36809768
Interactions between cadmium, lead, mercury, and arsenic and depression: A molecular mechanism involved., PMID:36758875
Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis., PMID:36709303
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity., PMID:36649378
CREBH alleviates mitochondrial oxidative stress through SIRT3 mediating deacetylation of MnSOD and suppression of Nlrp3 inflammasome in NASH., PMID:35926687
The Role and Mechanism of CREBH Regulating SIRT3 in Metabolic Associated Fatty Liver Disease., PMID:35902030
Unfolded protein response is involved in the metabolic and apoptotic regulation of oral squamous cell carcinoma., PMID:35791990
Effects of heavy metals on cardiovascular diseases in pre and post-menopausal women: from big data to molecular mechanism involved., PMID:35676585
CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis., PMID:35122696
Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer., PMID:34930465
Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV., PMID:34626126
Adipose expression of CREB3L3 modulates body weight during obesity., PMID:34588527
CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions., PMID:34579081
CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins., PMID:34491909
Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling., PMID:34042217
Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice., PMID:34023388
The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation., PMID:33789150
Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program., PMID:33592335
Making the Best of a Competition: the CREB3L3-SREBP Axis in Arteriosclerosis., PMID:33556363
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition., PMID:33246135
CREBH: A Complex Array of Regulatory Mechanisms in Nutritional Signaling, Metabolic Inflammation, and Metabolic Disease., PMID:32997872
N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1., PMID:32996649
Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia., PMID:32580631
Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH., PMID:32553626
CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease., PMID:32417373
Dysregulation in the Unfolded Protein Response in the FGR Rat Pancreas., PMID:32411226
Cleavage of cyclic AMP-responsive element-binding protein H aggravates myocardial hypoxia reperfusion injury in a hepatocyte-myocardial cell co-culture system., PMID:32389049
An in-vitro mechanical strain three-dimensional culture model: periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response., PMID:32141124
A successful term pregnancy with severe hypertriglyceridaemia and acute pancreatitis. Clinical management and review of the literature., PMID:31818441
Hepatocyte CREBH deficiency aggravates inflammatory liver injury following chemokine-dependent neutrophil infiltration through upregulation of NF-κB p65 in mice., PMID:31797000
Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway., PMID:31335288
CREB3 Transcription Factors: ER-Golgi Stress Transducers as Hubs for Cellular Homeostasis., PMID:31334233
Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling., PMID:31217010
For research use only. Not for human or drug use.
