Catalog No.
YHJ04101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met85-Gly284
Predicted molecular weight
49.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q676U5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATG16L1, Autophagy-related protein 16-1, APG16L, APG16-like 1
Dysregulation of Host Histone Acetylation by Acinetobacter baumannii: A Novel Mechanism for Autophagy Inhibition and Bacterial Survival., PMID:40509567
Unconventional role of ATG16L1 in the control of ATP compartmentalization during apoptosis., PMID:40509562
SETD5-Coordinated LC3B Methylation Inhibits Autophagy in Ovarian Cancer., PMID:40497358
The TECPR1:ATG5-ATG12 complex conjugates LC3/ATG8 to damaged lysosomes that expose luminal glycans in response to osmotic imbalance., PMID:40458442
Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy., PMID:40413757
NOD1 deficiency promotes inflammation via autophagic degradation of ASK1., PMID:40399666
ATG5 is dispensable for ATG8ylation of cellular proteins., PMID:40395522
Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection., PMID:40373771
Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - preliminary insights into a potential novel elastin-induced neurodegeneration pathway in an in vitro human cellular neuron model., PMID:40348194
The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway., PMID:40301304
The Role of WIPI2, ATG16L1 and ATG12-ATG5 in Selective and Nonselective Autophagy., PMID:40221132
Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms., PMID:40213394
ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury., PMID:40211890
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death., PMID:40210636
RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages., PMID:40196584
Multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in autism spectrum disorder., PMID:40158064
miR-278-3p targets ATG16L1 to modulate autophagy and suppresses CLas proliferation in Diaphorina citri., PMID:40154689
ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection., PMID:40143422
Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages., PMID:40138395
Chaperone-mediated autophagy degrades SERPINA1E342K/α1-antitrypsin Z variant and alleviates cell stress., PMID:40114294
Intronic region polymorphisms of autophagy gene ATG16L1 predispose individuals to Hepatitis B virus infection., PMID:40112491
LncRNA HITT inhibits autophagy by attenuating ATG12-ATG5-ATG16L1 complex formation., PMID:40021040
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma., PMID:40009568
STING-induced noncanonical autophagy regulates endolysosomal homeostasis., PMID:39982740
Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn's disease patients., PMID:39959979
Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy., PMID:39901351
Induction of lysosome biogenesis is a novel function of the CGAS-STING1 pathway., PMID:39835593
M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism., PMID:39804978
Structure of the WIPI3/ATG16L1 Complex Reveals the Molecular Basis for the Recruitment of the ATG12~ATG5-ATG16L1 Complex by WIPI3., PMID:39768203
Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1., PMID:39761761
Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator., PMID:39753134
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase., PMID:39723606
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy., PMID:39675054
Inhibition of XIST restrains paclitaxel resistance in breast cancer cells by targeting hsa-let-7d-5p/ATG16L1 through regulation of autophagy., PMID:39638138
ATG16L1 Depletion-Mediated Activation of the TRAF1 Signaling in Macrophages Aggravates Liver Fibrosis., PMID:39629085
Uncovering the Significance of JNK/AKT Axis in the Autophagic Regulation of Leishmania major Infection., PMID:39626091
Defective Atg16l1 in intestinal epithelial cells links to altered fecal microbiota and metabolic shifts during pregnancy in mice., PMID:39620359
Histopathological evidence of cellular alterations in the dentate gyrus is associated with aberrant RB1CC1-ATG16L1 expression in the hippocampus among older adults with chronic schizophrenia: A pilot post-mortem study., PMID:39612766
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection., PMID:39608349
Proteomic Analysis of Vibrio parahaemolyticus-Stimulated Pinctada martensii Proteins for Antimicrobial Activity, Potential Mechanisms, and Key Components., PMID:39596793
Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1., PMID:39587108
[Effect of baicalein regulating miR-7 on autophagy in human gastric cancer BGC-823 cells and its mechanism of action]., PMID:39566525
Association between ATG16L1 rs2241880(T300A) and rs4663421 and ANCA‑associated vasculitis in the Guangxi population of China: Propensity score matching analysis., PMID:39483332
Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8+ T cells., PMID:39464882
In vitro and in vivo reconstitution systems reveal the membrane remodeling ability of LC3B and ATG16L1 to form phagophore-like membrane cups., PMID:39385669
Whole Exome Sequencing Identifies Epithelial and Immune Dysfunction-Related Biomarkers in Food Protein-Induced Enterocolitis Syndrome., PMID:39348862
A pilocytic astrocytoma with novel ATG16L1::NTRK2 fusion responsive to larotrectinib: a case report with genomic and functional analysis., PMID:39326005
Complement C3 deposition restricts the proliferation of internalized Staphylococcus aureus by promoting autophagy., PMID:39310788
Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction., PMID:39284911
The role of autophagy in RIP1 mediated cell death and intestinal inflammation., PMID:39271257
For research use only. Not for human or drug use.
