Catalog No.
YHJ02401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro196
Predicted molecular weight
23.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5SQI0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C6orf134, TAT, MEC17, Alpha-TAT, ATAT1, Alpha-TAT1, Acetyltransferase mec-17 homolog, Alpha-tubulin N-acetyltransferase 1
Histone and N-terminal acetyltransferases play important roles in female reproduction and embryogenesis of the red flour beetle Tribolium castaneum., PMID:40437965
Impact of Type 1 Diabetes on Testicular Microtubule Dynamics, Sperm Physiology, and Male Reproductive Health in Rat., PMID:40429724
Identification of Histone and N-Terminal Acetyltransferases Required for Reproduction and Embryonic Development of Yellow Fever Mosquito, Aedes aegypti., PMID:40235318
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress., PMID:39820277
Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death., PMID:39741209
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition., PMID:39639346
Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium., PMID:39528655
Endothelial cell elongation and alignment in response to shear stress requires acetylation of microtubules., PMID:39318362
Eml1 promotes axonal growth by enhancing αTAT1-mediated microtubule acetylation., PMID:38897390
Lactylation of NAT10 promotes N4-acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation., PMID:38879723
Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ., PMID:38835115
Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation., PMID:38759377
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases., PMID:38652325
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair., PMID:38632359
Microtubule association of TRIM3 revealed by differential extraction proteomics., PMID:38149663
Microtubule acetylation induced by oxidative stress regulates subcellular distribution of lysosomal vesicles for amyloid-beta secretion., PMID:37801327
Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization., PMID:37403793
Genetic dissection of behavioral traits related to successful training of drug detection dogs., PMID:37147374
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice., PMID:36881554
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations., PMID:36550158
Molecular Analysis of Axonal Transport Dynamics upon Modulation of Microtubule Acetylation., PMID:35412278
Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein., PMID:35275978
Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations., PMID:35181405
Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation., PMID:34820375
ATP-citrate lyase promotes axonal transport across species., PMID:34620845
Embryogenic Calli Induction and Salt Stress Response Revealed by RNA-Seq in Diploid Wild Species Gossypium sturtianum and Gossypium raimondii., PMID:34512696
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion., PMID:34508164
The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol., PMID:34502304
Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis., PMID:34440628
Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress., PMID:34199510
Pharmacophore anchor models of ATAT1 to discover potential inhibitors and lead optimization., PMID:34052673
p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation., PMID:33986251
Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo., PMID:33985412
Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition., PMID:33672816
BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation., PMID:33629936
HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome., PMID:33626373
Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice., PMID:33390366
VDAC upregulation and αTAT1‑mediated α‑tubulin acetylation contribute to tanespimycin‑induced apoptosis in Calu‑1 cells., PMID:33125132
PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension., PMID:33066011
Identification of hub genes, miRNAs and regulatory factors relevant for Duchenne muscular dystrophy by bioinformatics analysis., PMID:32791870
Role of tubulin acetylation in cellular functions and diseases., PMID:32632910
Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila., PMID:32589908
ATAT1-enriched vesicles promote microtubule acetylation via axonal transport., PMID:31897425
Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation., PMID:31878840
Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets., PMID:31373507
ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation., PMID:30953095
Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration., PMID:30858195
Ac-SDKP increases α-TAT 1 and promotes the apoptosis in lung fibroblasts and epithelial cells double-stimulated with TGF-β1 and silica., PMID:30826375
Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages., PMID:30761140
GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking., PMID:30333138
For research use only. Not for human or drug use.
