Catalog No.
YHJ01601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu308
Predicted molecular weight
34.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5HY92
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fidgetin, FIGN
Identification of a Growth-Promoting Gene Cluster in the Region 2q24 as a Driver of Tumorigenesis in Childhood Hepatoblastoma., PMID:40316217
Evolution and functional divergence of the Fidgetin family., PMID:39481482
SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells., PMID:38997783
Efficacy of Immediate Antihypertensive Treatment in Patients With Acute Ischemic Stroke With Different Blood Pressure Genetic Variants., PMID:38174564
Construction of novel 7 integrin-related gene signatures in thyroid cancer construction of model based on integrin genes., PMID:38115319
Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner., PMID:36586551
Fidgetin knockdown and knockout influences female reproduction distinctly in mice., PMID:35965436
Interstitial 2q24.2q24.3 Microdeletion: Two New Cases with Similar Clinical Features with the Exception of Profound Deafness., PMID:35896065
Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis., PMID:35853630
Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development., PMID:33585441
Age-related DNA methylation changes are sex-specific: a comprehensive assessment., PMID:33276343
Fidgetin as a potential prognostic biomarker for hepatocellular carcinoma., PMID:33162817
A comparative study of the expression patterns of Fign family members in zebrafish embryonic development., PMID:33069857
A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule‑severing function., PMID:32236575
Genetic linkage analysis of a large family identifies FIGN as a candidate modulator of reduced penetrance in heritable pulmonary arterial hypertension., PMID:30894412
Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism., PMID:30647150
Microtubule-severing enzymes: From cellular functions to molecular mechanism., PMID:30373906
Nanoparticle Delivery of Fidgetin siRNA as a Microtubule-based Therapy to Augment Nerve Regeneration., PMID:28852085
A Genetic Variant in FIGN Gene Reduces the Risk of Congenital Heart Disease in Han Chinese Populations., PMID:28534241
Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility., PMID:28302752
[Role of microtubule severing proteins in cytoskeleton reorganization]., PMID:28132445
[Microtubule severing proteins - structure and activity regulation]., PMID:28132444
Fidgetin regulates cultured astrocyte migration by severing tyrosinated microtubules at the leading edge., PMID:27974640
The defining DNA methylation signature of Floating-Harbor Syndrome., PMID:27934915
The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration., PMID:27411367
Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules., PMID:26344772
Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing., PMID:25756798
Heterogeneous effects of association between blood pressure loci and coronary artery disease in east Asian individuals., PMID:25740055
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer., PMID:25485836
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension., PMID:25249183
Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis., PMID:22672901
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples., PMID:21621269
Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes., PMID:17452528
Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts., PMID:17352653
Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse., PMID:16751186
Mutational analysis of the functional motifs in the ATPase domain of Caenorhabditis elegans fidgetin homologue FIGL-1: firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases., PMID:16621600
Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice., PMID:15707573
The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development., PMID:11017077
Translation/secretion coupling by type III secretion systems., PMID:10966110
Novel genes that upregulate the Proteus mirabilis flhDC master operon controlling flagellar biogenesis and swarming., PMID:9723914
For research use only. Not for human or drug use.
