Catalog No.
YHH88901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn312
Predicted molecular weight
36.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q53GQ0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3-ketoacyl-CoA reductase, SDR12C1, Estradiol 17-beta-dehydrogenase 12, Very-long-chain 3-oxoacyl-CoA reductase, KAR, 17-beta-HSD 12, HSD17B12, 17-beta-hydroxysteroid dehydrogenase 12, Short chain dehydrogenase/reductase family 12C member 1
Functional Analysis of HSD17B3-Deficient Male Mice Reveals Roles for HSD17B7 and HSD17B12 in Testosterone Biosynthesis., PMID:40336300
Characterization of a direct role of GnRHs in the control of spermiogenesis and steroidogenesis in the small-spotted catshark Scyliorhinus canicula., PMID:40254036
Biological and therapeutic implications of sex hormone-related gene clustering in testicular cancer., PMID:40011822
A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep., PMID:39986531
miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort., PMID:39976655
Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes., PMID:39556387
Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis., PMID:39248019
Single-nucleus multiomics unravels the genetic mechanisms underlying musk secretion in Chinese forest musk deer (Moschus berezovskii)., PMID:39214228
Dynamics of HSD17B3 expression in human fetal testis: implications for the role of Sertoli cells in fetal testosterone biosynthesis., PMID:39139451
Identification of potential differences in salivary proteomic profiles between estrus and diestrus stage of estrous cycle in dairy cows., PMID:39008339
The mitochondrial protease PARL is required for spermatogenesis., PMID:38182793
Integrative proteome and metabolome analyses reveal molecular basis underlying growth and nutrient composition in the Pacific oyster, Crassostrea gigas., PMID:37838097
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine., PMID:37722844
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time., PMID:37468957
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism., PMID:36724833
Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population., PMID:36563763
Differential proteomics analysis of JEG-3 and JAR placental cell models and the effect of androgen treatment., PMID:35690242
Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck., PMID:35404482
Relationships between prostaglandin concentrations, a single nucleotide polymorphism in HSD17B12, and reproductive performance in dairy cows., PMID:35221066
HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice., PMID:35187845
Dynamic transcriptome analysis of ovarian follicles in artificial maturing Japanese eel (Anguilla japonica)., PMID:34990963
Association of genetic polymorphisms with local steroid metabolism in human benign breasts., PMID:34762930
Steroid profiling and genetic variants in Chinese women with gestational diabetes mellitus., PMID:34547380
Rational design of 17β-hydroxysteroid dehydrogenase type3 for improving testosterone production with an engineered Pichia pastoris., PMID:34455250
A large cohort of disorders of sex development and their genetic characteristics: 6 novel mutations in known genes., PMID:33516834
Integrating GWAS and eQTL to predict genes and pathways for non-syndromic cleft lip with or without palate., PMID:33128317
Functional genetic variant of HSD17B12 in the fatty acid biosynthesis pathway predicts the outcome of colorectal cancer., PMID:33118286
Preclinical Pharmacokinetics, Tissue Distribution and Primary Safety Evaluation of a Novel Curcumin Analogue H10 Suspension, a Potential 17β Hydroxysteroid Dehydrogenase Type 3 Inhibitor., PMID:33087639
Potential GnRH and steroidogenesis pathways in the scallop Patinopecten yessoensis., PMID:32979503
Molecular genetics of disorders of sex development in a highly consanguineous population., PMID:32784047
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice., PMID:32691632
Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production., PMID:32557858
Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response., PMID:32492431
The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3., PMID:32457626
Novel Deleterious Mutation in Steroid-5α-Reductase-2 in 46, XY Disorders of Sex Development: Case Report Study., PMID:32449406
The novel founder homozygous V225M mutation in the HSD17B3 gene causes aberrant splicing and XY-DSD., PMID:32372306
The effects of chronic cadmium exposure on Bufo gargarizans larvae: Histopathological impairment, gene expression alteration and fatty acid metabolism disorder in the liver., PMID:32199138
Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids., PMID:31926269
17β-Hydroxysteroid dehydrogenase type 12a responsible for testicular 11-ketotestosterone synthesis in the Japanese eel, Anguilla japonica., PMID:31778803
Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration., PMID:31302749
Features of the fetal gonad in androgen synthesis in the postpubertal testis are preserved in complete androgen insensitivity syndrome due to a novel genetic splice site donor variant in androgen receptor gene intron 1., PMID:31283987
Expression of steroidogenic enzymes in human placenta according to the gestational age., PMID:30896833
Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival., PMID:30734280
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes., PMID:30508570
Rapid masculinization and effects on the liver of female western mosquitofish (Gambusia affinis) by norethindrone., PMID:30359922
Maternal BDE-209 exposure during lactation perturbs steroidogenesis, germ cell kinetics and THRα1 expression in testes of prepubertal mice offspring., PMID:30300726
Tribulus terrestris Protects against Male Reproductive Damage Induced by Cyclophosphamide in Mice., PMID:30228856
Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer., PMID:30181386
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung., PMID:29788210
The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer., PMID:29324448
For research use only. Not for human or drug use.
