Catalog No.
YHH79801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala744-Asn824
Predicted molecular weight
11.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q4KMQ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SCAN channel, ANO6, TMEM16F, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, Anoctamin-6
Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage., PMID:40388745
Ion Channel Function of Human TMEM16F Is Associated with Phospholipid Transport through Its Subunit Cavity., PMID:40350307
Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate., PMID:40244852
ANO6 Targets TMEM30A to Regulate Endoplasmic Reticulum Stress-Induced Lipid Peroxidation and Ferroptosis in Alzheimer's Cells., PMID:40221538
ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION., PMID:39874534
Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair., PMID:39794444
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families., PMID:39715905
HEK293 Cell-Based Assay to Measure the Lipid Scrambling Activity of TMEM16 Family Members., PMID:39699728
Identification and Experimental Validation of Prognostic miRNA Signature and Ferroptosis-Related Key Genes in Cervical Squamous Cell Carcinoma., PMID:39526479
Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice., PMID:39423958
Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study., PMID:39358671
Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies., PMID:39337485
The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels., PMID:39143141
TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and Metabolism to Protect Against Listeria Monocytogenes., PMID:39136057
TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons., PMID:38941274
TMEM16F scramblase regulates angiogenesis via endothelial intracellular signaling., PMID:38940198
TRPV4 and chloride channels mediate volume sensing in trabecular meshwork cells., PMID:38881423
Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1., PMID:38833990
T-reg transcriptomic signatures identify response to check-point inhibitors., PMID:38710724
The Effect of Calcium Ions on the Electrophysiological Properties of Single ANO6 Channels., PMID:38698960
The anoctamins: Structure and function., PMID:38642428
Comprehensive functional characterization of a novel ANO6 variant in a new patient with Scott syndrome., PMID:38492852
OxLDL enhances procoagulant activity of endothelial cells by TMEM16F-mediated phosphatidylserine exposure., PMID:38444077
An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer., PMID:38238671
A novel GATA1 variant p.G229D causing the defect of procoagulant platelet formation., PMID:38159323
Calcium chelation independent effects of BAPTA on endogenous ANO6 channels in HEK293T cells., PMID:38100999
Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis., PMID:38033286
Neuraminidase-induced externalization of phosphatidylserine activates ADAM17 and impairs insulin signaling in endothelial cells., PMID:37999645
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract., PMID:37979051
ANO6 is a reliable prognostic biomarker and correlates to macrophage polarization in breast cancer., PMID:37960776
Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins., PMID:37686084
Analysis of a new therapeutic target and construction of a prognostic model for breast cancer based on ferroptosis genes., PMID:37643511
Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix., PMID:36907435
Dysregulation of ADAM10 shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalization., PMID:36790936
Diagnosing Czech Patients with Inherited Platelet Disorders., PMID:36430862
Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity., PMID:36370845
Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition., PMID:35839776
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion., PMID:35670667
Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia., PMID:35670331
Significance of Anoctamin 6 in progression and prognostic prediction of gastric adenocarcinoma., PMID:35548923
Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck disease compared with osteoarthritis., PMID:35526762
In Silico Analysis of Ion Channels and Their Correlation with Epithelial to Mesenchymal Transition in Breast Cancer., PMID:35326596
Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases., PMID:35008658
BVES is a novel interactor of ANO5 and regulates myoblast differentiation., PMID:34963485
Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy., PMID:34450215
Anion and Cation Permeability of the Mouse TMEM16F Calcium-Activated Channel., PMID:34445284
TMEM16F and dynamins control expansive plasma membrane reservoirs., PMID:34404808
Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release., PMID:34390515
Thrombin generation abnormalities in commonly encountered platelet function disorders., PMID:34185390
Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl- Channels Induced by Local Ca2+ Entry in HEK293., PMID:33946319
For research use only. Not for human or drug use.
