Catalog No.
YHH38301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu347
Predicted molecular weight
40.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16828
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitogen-activated protein kinase phosphatase 3, MKP3, DUSP6, PYST1, MAP kinase phosphatase 3, Dual specificity protein phosphatase PYST1, Dual specificity protein phosphatase 6, MKP-3
Identification of Novel Genetic Variants in a Cohort of Congenital Hypogonadotropic Hypogonadism: Computational Analysis of Pathogenicity Predictions., PMID:40508017
Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis., PMID:40481499
Dual-specificity phosphatases: Potential targets for cognitive impairment induced by chronic kidney disease., PMID:40424657
Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity., PMID:40339008
Identification of potential anti aging drugs and targets in chronic kidney disease., PMID:40319112
Genome-wide chromatin accessibility and transcriptome analysis reveal the up-regulation of immunosuppressive genes in macrophages under simulated microgravity., PMID:40280635
[Retracted] Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway., PMID:40145576
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting., PMID:40083690
Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation and cell cycle progression., PMID:40067243
FBXL14 inhibits foam cell formation and atherosclerosis plaque progression by activating the NRF2 signal axis through ubiquitination of DUSP6., PMID:40051291
RPL22L1 fosters malignant features of cervical cancer via the modulation of DUSP6-ERK axis., PMID:40022129
ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism., PMID:39862096
Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium-Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction., PMID:39806544
A monoamine oxidase B inhibitor altered gene expression of catalytically active dual-specificity phosphatases in human oral gingival keratinocytes., PMID:39749374
Investigating protein degradability through site-specific ubiquitin ligase recruitment., PMID:39711601
Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa., PMID:39682729
The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish., PMID:39610242
Investigating Protein Degradability through Site-Specific Ubiquitin Ligase Recruitment., PMID:39605659
DUSP6 regulates Notch1 signalling in colorectal cancer., PMID:39572549
Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients., PMID:39528952
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats., PMID:39498753
PEGylated Titanium Dioxide Nanoparticle-bound Doxorubicin and Paclitaxel Drugs Affect Prostate Cancer Cells and Alter the Expression of DUSP Family Genes., PMID:39473102
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations., PMID:39436655
Polyphyllin VI Ameliorates Pulmonary Fibrosis by Suppressing the MAPK/ERK and PI3K/AKT Signaling Pathways via Upregulating DUSP6., PMID:39417325
A phase Ib study of the combination of naporafenib with rineterkib or trametinib in patients with advanced and metastatic KRAS- or BRAF-mutant non-small cell lung cancer., PMID:39383771
Multi-omics and bioinformatics for the investigation of therapeutic mechanism of roucongrong pill against postmenopausal osteoporosis., PMID:39362330
GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway., PMID:39353395
Ethanol enhances selenoprotein P expression via ERK-FoxO3a axis in HepG2 cells., PMID:39345286
ASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung Cancers., PMID:39295275
DNA methylation and histone modifications associated with antipsychotic treatment: a systematic review., PMID:39227433
DUSP6 protein action and related hub genes prevention of sepsis-induced lung injury were screened by WGCNA and Venn., PMID:39197622
WT1 together with RUNX1::RUNX1T1 targets DUSP6 to dampen ERK activity in acute myeloid leukaemia., PMID:39191510
Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis., PMID:39133135
Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma., PMID:39052598
In vivo vitamin D target genes interconnect key signaling pathways of innate immunity., PMID:39042613
ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma., PMID:39019900
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice., PMID:39006222
Overexpression of CENPU promotes cancer growth and metastasis and is associated with poor survival in patients with nasopharyngeal carcinoma., PMID:38988917
Value of DUSP6 in peripheral blood mononuclear cells in predicting adverse cardiovascular events after peritoneal dialysis in diabetic nephropathy., PMID:38970509
Sevoflurane augments neuroinflammation by regulating DUSP6 via YTHDF1 in postoperative cognitive dysfunction., PMID:38966092
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages., PMID:38937789
BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF., PMID:38890235
DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer., PMID:38886591
Functional Role of DUSP6 in the EGFR-mediated Progression of Head and Neck Squamous Cell Carcinoma., PMID:38821599
TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction., PMID:38718254
Calcium saccharate/DUSP6 suppresses renal cell carcinoma glycolytic metabolism and boosts sunitinib efficacy via the ERK-AKT pathway., PMID:38697311
Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina., PMID:38679247
Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway., PMID:38678784
Bioinformatics analysis and identification of potential key genes and pathways in the pathogenesis of nonischemic cardiomyopathy., PMID:38669428
Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP., PMID:38664011
For research use only. Not for human or drug use.
