Catalog No.
YHH36401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val29-Leu361
Predicted molecular weight
40.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16769
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
sQC, Glutaminyl-tRNA cyclotransferase, QC, QPCT, Glutamyl cyclase, EC, Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase
Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus., PMID:40311753
FTO-mediated m6A modification of QPCT promotes tumorigenesis in lung adenocarcinoma by inducing macrophage chemotaxis and M2 polarization., PMID:40226457
Preliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation., PMID:39854580
Targeting QPCTL: An Emerging Therapeutic Opportunity., PMID:39746038
Increased QPCT gene expression by the hepatitis B virus promotes HBV replication., PMID:39531472
Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease., PMID:39422941
Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity., PMID:39411310
Identification of potential biomarkers of papillary thyroid carcinoma., PMID:39400774
Identification of atrial fibrillation-related genes through transcriptome data analysis and Mendelian randomization., PMID:39055656
Identification of imidazole-based small molecules to combat cognitive disability caused by Alzheimer's disease: A molecular docking and MD simulations based approach., PMID:39038422
Causal association and shared genetics between telomere length and COVID-19 outcomes: New evidence from the latest large-scale summary statistics., PMID:38882679
Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivity., PMID:38417050
Bioinformatics and Machine Learning Methods Identified MGST1 and QPCT as Novel Biomarkers for Severe Acute Pancreatitis., PMID:38236462
Proteomic analysis of boar sperm with differential ability of liquid preservation at 17 °C., PMID:38029685
Therapeutic potential of glutaminyl cyclases: Current status and emerging trends., PMID:37244566
Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer., PMID:37060824
Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis., PMID:36459066
Differences of macrophages in the tumor microenvironment as an underlying key factor in glioma patients., PMID:36389681
Heart failure in obesity: insights from proteomics in patients treated with or without weight-loss surgery., PMID:35945262
Alterations in Toll-Like Receptor 7 and -9 mRNA Levels in Lungs after Ovariohysterectomy in a Pyometra Mouse Model., PMID:34959241
Bioinformatic analysis identifies potential key genes of epilepsy., PMID:34555062
Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis., PMID:34177888
QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis., PMID:34036385
Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury., PMID:33863396
Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia., PMID:32763516
Bioinformatic analysis and experimental identification of blood biomarkers for chronic nonunion., PMID:32503597
DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma., PMID:31534544
Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens., PMID:30974000
Molecular characterization of glutaminyl-peptide cyclotransferase(QPCT)in Scylla paramamosain and its role in Vibrio alginolyticus and white spot syndrome virus (WSSV) infection., PMID:29709591
High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases., PMID:29109100
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity., PMID:28739588
Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population., PMID:26492838
Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct., PMID:26447138
Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras., PMID:26361962
Arsenic Trioxide Activate Transcription of Heme Oxygenase-1 by Promoting Nuclear Translocation of NFE2L2., PMID:26283888
Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets., PMID:25950827
siRNA screen identifies QPCT as a druggable target for Huntington's disease., PMID:25848931
Sperm DNA methylation analysis in swine reveals conserved and species-specific methylation patterns and highlights an altered methylation at the GNAS locus in infertile boars., PMID:25320151
Glycosylation of immunoglobulin g: role of genetic and epigenetic influences., PMID:24324808
A New Quantum Calibrated Force Field for Zinc-Protein Complex., PMID:26587635
Role of glutaminyl cyclases in thyroid carcinomas., PMID:23183267
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers., PMID:23034519
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation., PMID:21900558
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions., PMID:21774078
FN1, GALE, MET, and QPCT overexpression in papillary thyroid carcinoma: molecular analysis using frozen tissue and routine fine-needle aspiration biopsy samples., PMID:20607686
Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals., PMID:17334644
Epigenetic silencing of novel tumor suppressors in malignant melanoma., PMID:17145863
For research use only. Not for human or drug use.
