Catalog No.
YHH33401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala33-Thr272
Predicted molecular weight
28.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16651
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Prostasin, PRSS8, Channel-activating protease 1, Serine protease 8, CAP1
Night Shift Work and Lung Cancer Risk: A Prospective Cohort Study with Mediator Analysis from the UK Biobank., PMID:40488442
Mendelian randomization identifies proteins involved in neurodegenerative diseases., PMID:40037332
Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development., PMID:39747972
GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumour relapse in intestinal cancer., PMID:39743241
Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane., PMID:39730982
Unveiling Novel Protein Biomarkers for Psoriasis Through Integrated Analysis of Human Plasma Proteomics and Mendelian Randomization., PMID:39669686
Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization., PMID:39586554
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients., PMID:39334929
Secondary TFE3-Rearranged Renal Cell Carcinoma in a Chinese Girl Treated for Wilms Tumor: Case Report and Literature Review., PMID:39286920
Protein signatures associated with loneliness and social isolation: plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization., PMID:39211870
The Role of Serine Protease 8 in Mediating Gefitinib Resistance in Non-small Cell Lung Cancer., PMID:39041267
Altered proteome profiles related to visceral adiposity may mediate the favorable effect of green Mediterranean diet: the DIRECT-PLUS trial., PMID:38757229
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis., PMID:38521921
Identification and validation of IRF6 related to ovarian cancer and biological function and prognostic value., PMID:38493179
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation., PMID:38462165
A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy., PMID:38335839
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation., PMID:38271183
Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications., PMID:38139392
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress., PMID:37958518
Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement., PMID:37863260
Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity., PMID:37830556
Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway., PMID:37277555
Identification of novel urine proteomic biomarkers for high stamina in high-altitude adaptation., PMID:37250129
HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes., PMID:37076641
N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity., PMID:36637420
Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels., PMID:36344042
Prostate cancer-associated urinary proteomes differ before and after prostatectomy., PMID:36324734
Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer., PMID:36300085
Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses., PMID:36180668
Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway., PMID:35743186
Sodium retention in the nephrotic syndrome and the non-enzymatic function of prostasin., PMID:35344088
Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity., PMID:35312839
ENaC activation by proteases., PMID:35276025
Common physiologic and proteomic biomarkers in pulmonary and coronary artery disease., PMID:35263363
Sex differences in proteomic correlates of coronary microvascular dysfunction among patients with heart failure and preserved ejection fraction., PMID:35060248
Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network analysis., PMID:34922114
Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice., PMID:34870751
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer., PMID:34823420
Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs., PMID:34666057
The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2., PMID:34643933
Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization., PMID:34562451
A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome., PMID:34524424
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice., PMID:34361079
Prostasin regulates PD-L1 expression in human lung cancer cells., PMID:34240739
Prostasin regulates PD-L1 expression in human lung cancer cells., PMID:34195807
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells., PMID:34089062
Proteomic profiling for detection of early-stage heart failure in the community., PMID:34050710
Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity., PMID:33987838
Non-enzymatic function of prostasin and sodium balance., PMID:33721422
Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2., PMID:33669738
For research use only. Not for human or drug use.
